#NoncodingRNA plays a crucial role in #butterfly #speciation—but what about other #flora and #fauna? A PNAS Inner Workings: #microRNA #LongNoncodingRNA #evolution #PepperedMoth #MonkeyFlower

#LongNoncodingRNA #SmoothMuscleCell #Seneascence #Atherosclerosis. LncRNA JPX (just proximal to XIST), in complex with #BRD4 NF-κB, acts as a ROS-Cytosolic #mtDNA-STING downstream to transcriptionally activate #SASP genes (IL-1β/-6/-8 MCP1 TNFα) in senescent SMCs. SMC Jpx KO

#LongNonCodingRNA #LncRNA transcriptomics Lower-extremity #PeripheralArteryDisease -/+ T2D #Diabetes. Iliac artery n=79.T2D->⏬ACTA2-AS1. #SmoothMuscleCell microdissected from FFPE section.T2D->⏫LINC00910/RUFY1-AS1/MZF1-AS1 ⏬HIF1A-AS3/XIST!/NEAT1/MIR222HG/MIR28B2CHG. More

#LongNonCodingRNA #Senescence #Atherosclerosis. JPX, a chromosome-associated regulatory RNA, complexes with BRD4 & p65 (NFκB subunit) to mediates 3D chromatin remodeling &⏫transcriptional activation of senescence secretome genes (CCL2/IL-1β/-6/-8/TNFα) in #SmoothMuscleCell. A

"Long Noncoding #RNA in #Myeloid and #Lymphoid #Cell Differentiation, Polarization and Function" from Ahmad et al. #cellsmdpi #cellbiology #longnoncodingRNA #myeloidcells #lymphoidcells #immuneresponses. Full text:

Our March issue:. Perspective by Brian Luke on Regulatory R-loops as facilitators of gene expression and genome stability @imbmainz @LukeLab2 .#LongNonCodingRNA #RLoops #GenomicInstability . Access here:

Long noncoding RNA mediates stroke‐induced neurogenesis. #epigenetics #H19 #longnoncodingRNA #neurogenesis #stroke

"#Cholangiocyte-Derived #Exosomal #lncRNA #H19 Promotes #Macrophage Activation and #Hepatic #Inflammation under #Cholestatic Conditions" from Li et al. #cellsmdpi #cellbiology #longnoncodingRNA. Full text:

The Clinical Significance of Long Non-Coding RNAs in Cancer #RNA #Cancer #Oncology #LongNonCodingRNA #NonCodingRNA

#LongNonCodingRNA #SmoothMuscleCell. LncDACH1⏬SMC proliferation+migration & #Neointima of #ArterioVenousFistula, partially via ⏬HSP90 abundance & sequestrating SRPK1 in the nuclei in an HSP90-dependent manner. LncDACH1 physically binds to SRPK1 (RNA-IP assay). LncDACH1 is

I did a thing! Highly commended for my scientific poster! Obviously wouldn't have been possible without the guidance of @niamhforde and @RNA_julie so huge props! #Fertility2019 #Reproduction #PhDlife #longnoncodingrna .Thanks to SRF for the bursary and the award @SRF_Repro!

Epigenetic Regulation of #Angiogenesis in #PeripheralArteryDisease. A nice review on #LongNonCodingRNA in #EndothelialCell #MuralCell.👤🐭#LimbIschemia. MALAT1.MEG3.SNHG12.ANRIL.LEENE.SENCR.HIF1A-AS1/2. @NMalhi92 @ZhenBoumanChen #DeBakeyCVJournal 2023.

Emerging Role of Non-Coding RNAs in Aortic Dissection. Interesting summary of #microRNA #LongNonCodingRNA #CircularRNA in the pathogenesis & diagnosis of #AorticDissection. XIST🤡.SENCR😮.CircTGFBR2🧐. Dr. Jianxun Wang & Yufang Gao labs @Biomol_MDPI 2022.

🔎#Telomere maintenance in cancer.✂The exoribonuclease XRN2 degrades the long non-coding #telomeric RNA TERRA. 🖊Rachel Litman Flynn & team @BUMedicine .➡ 📌In our #CancerBiology Special Section.➡ #ribonuclease #longnoncodingRNA

REVIEW Reactive modifications of DNA nucleobases for labelling, bioconjugations, and cross-linking. @hocekm .#microRNA #aptamer #mRNA #ASO #oligonucleotides #siRNA #oligochemistry #longnoncodingRNA @IS3NA @arseniyadis @Prof_Tom_Brown @BurleyResearch @mmckeague

REVIEW: Guidelines for Experiments Using #Antisense #Oligonucleotides and Double-Stranded RNAs. #siRNA #RNAi @RNAi_papers #gapmer #ASO #splicemodulation @oligogirl #microRNA #antagomiR #agomiR @microRNA_papers #miRNA #longnoncodingRNA #lncRNA .

Interested in the function of #LongNonCodingRNA and their molecular mode of action in #PathologicalCariacRemodeling and #MyocardialInfarction? . Read the summary below from Dr. Hobuß and co. 🧬.

This #VirtualIssue of IUBMB Life reports significant progress towards understanding the specific roles and mechanisms of action of diverse #lncRNAs. ➡️ Curated by Associate Editor @toni_gabaldon. #lincRNA #lncRNA #longnoncodingRNA #RNA #pubmed #science

Now online Perspective by Brian Luke on Regulatory R-loops as facilitators of gene expression and genome stability @imbmainz @LukeLab2 #LongNonCodingRNA #RLoops #GenomicInstability .