The CPP Section’s June Pharmacotherapy Literature Update features 10 summaries of recent publications on topics such as cardiogenic shock, early NE in septic shock, & inhaled sedation in ARDS. CPP members can access this through Connect: #PharmICU #CPPPLU

#CPPPLU Highlights: The EXPECTS Trial from @NEJM evaluated the safety and efficacy of alteplase between 4.5 to 24 hours after posterior circulation ischemic stroke. Treatment resulted in increased frequency of functional independence at 90 days. #PharmICU

The May #CPPPLU features 9 summaries of recent publications including albumin in septic shock & renal failure, aminoglycosides in urosepsis, & reversal of rocuronium in CT surgery patients with COVID-19. 💉 Check it out via @SCCM Connect: #PharmICU #CPPPLU

#CPPPLU Highlight: A meta-analysis published in @Crit_Care found an association between early initiation of norepinephrine and reduced mortality in patients with septic shock. #PharmICU

#CPPPLU Highlights: A recent feasibility study in @critcaremed found that dexmedetomidine administration in septic shock resulted in a ↓ in vasopressor responsiveness and an ↑ in early mortality #PharmICU #CPPPLU.

#CPPPLU Highlights: A recent RCT in @JCVAonline examining hydroxocobalamin administration at the end of cardiopulmonary bypass showed significantly higher MAP compared to placebo as well as reduction in development of vasoplegia. #PharmICU #CPPPLU

#CPPPLU Highlights: Nelonemdaz, a novel NMDA receptor subtype 2B-selective antagonist and potent free-radical scavenger, may improve outcomes in OHCA, seen in the phase II AWAKE trial in @CritCareMed. #PharmICU

CPPPLU Highlights: A recent multicenter study in @of_AIC found that the addition of empiric aminoglycosides for urosepsis did not improve mortality, but also did not cause worsening nephrotoxicity. #PharmICU #CPPPLU

#CPPPLU Highlights: This recent publication from @JACCJournals provides guidance on the evaluation and management of cardiogenic shock. Early diagnosis and management of cardiogenic shock is crucial. #PharmICU

CPPPLU Highlights: New in @accpchest co-authored by CPP members Asad Patanwala, @AflanneryPharmD, and Brian Erstad: Early albumin (esp. 25%) in septic shock w/ renal impairment linked to ↑ RRT or death. Surprising signal of harm! #PharmICU #CPPPLU

#CPPPLU Highlights: A study in @JCVAonline found that reversal of NMBA with sugammadex in COVID-19 patients undergoing CT surgery had ⬇️ pulmonary complications including pneumonia and respiratory failure. 💉 #PharmICU #CPPPLU

#CPPPLU Highlights: This recent trial from @of_AIC explored the use of high-dose IV vitamin C in moderate to severe acute pancreatitis. They found a potential benefit on C-reactive protein levels and fluid retention in moderate illness. #PharmICU

#CPPPLU Highlights: Rapid PCR testing in ICUs may improve antibiotic stewardship, but does not demonstrate non-inferiority to standard-of-care for clinical outcomes according to a recent study in @yourICM .#PharmICU #CPPPLU

#CPPPLU Highlights. A recent study in @JCVAonline found that hydroxocobalamin was associated with a greater reduction in vasopressor requirements and ↑ in MAP compared to methylene blue for vasoplegic shock post-CPB. #PharmICU .

Can’t wait to hear @pwierusz thoughts on ang II use! Thanks to @SCCM_CPP and the #CPPPLU for highlighting these studies!.