Critical Care Medicine
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Critical Care Medicine covers all aspects of care for the critically ill or injured patient. Official journal of @SCCM . Tweets by @aartisarwal . #CritCareMed
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Last Seen Profiles
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019
Joint effort by
@SCCM
@ESICM
Pre-print version to be co-published in
@CritCareMed
and
@yourICM
#SurvivingSepsis
Link:
2
158
241
2021
#SurvivingSepsis
Guidelines
Website:
Link Article:
👊 Best practices & recommendations for treatment of
#sepsis
#septic
#AdultICU
3
90
185
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019
Joint effort by
@SCCM
@ESICM
Co-published in
@CritCareMed
and
@yourICM
#SurvivingSepsis
#OpenAccess
Link:
1
118
166
The Effect of Propofol and Dexmedetomidine Sedation on Norepinephrine Requirements in Septic Shock Patients: A Crossover Trial
3
81
147
Current Issue: Association of Driving Pressure With Mortality Among Ventilated Patients With Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis*
3
69
121
Largest set of Medicare
#sepsis
data reported: 9.5 M inpatient admissions -3 articles
1-The Burdens of Sepsis
2-The Trajectories of Sepsis
3-The Methods,Models, & Forecasts of Sepsis
@SCCM
@PHEgov
@BARDA
@TimBuchmanMDPhD
#CritCareMed
#CCC49
Link:
1
75
117
Iba et al: Narrative review on coagulopathy in
#COVID19
associated severe
#ARDS
Link:
#CritCareMed
@SCCM
Fig: Various types of thrombus formation in
#COVID
-19.
0
58
114
#VisualAbstract
Sacha et al: Higher norepi-eq dose & higher lactate at vasopressin initiation
👉higher in-hosp mortality in
#septicshock
pts who received vasopressin
Link:
Editorial:
#CritCareMed
@SCCM
#SurvivingSepsis
2
33
109
#FreeArticle
#SCCM50years
@mpkerlin
et al: History of ICU Organization and Management
Link:
@SCCM
#CritCareMed
@DeenaKCosta
@PittCCM
Fig: ICUs in 1970 and today
2
43
109
Revisiting
#VisualAbstract
2020
Hurth et al: Re-emerging support for ketamine use in pts w' pain, alcohol withdrawal syndrome, status epilepticus, & acute agitation-literature review.
Link:
#CritCareMed
@SCCM
#pedsICU
#ICUdelirium
2
45
108
#COVID19
#ONLINEFIRST
Iba et al: Severe
#ARDS
#COVIS
-19 induces microangiopathy & large vessel thrombosis in
#adultICU
pts.
- monitor D-dimer & fibrinogen
- DVT prophylaxis for all ICU pts
Link:
#CritCareMed
@SCCM
Fig: Thrombus formation in
#COVID
-19
0
65
105
Conway et al: Ketamine use for induction during tracheal intubation in
#PedsICU
may be protective against adverse hemodynamic events.
Link:
#CritCareMed
@sccm
#PedsICU
Fig: Multivariable Analysis: Hemodynamic Adv Events w' Ketamine
2
62
105
Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis
5
71
104
Hurth et al: Re-emerging support for ketamine use in pts w' pain, alcohol withdrawal syndrome, status epilepticus, & acute agitation-literature review.
Link:
#CritCareMed
@sccm
#pedsICU
#ICUdelirium
Fig: Ketamine Dosing & Safety
1
45
101
Hurth et al: Re-emerging support for ketamine use in pts w' pain, alcohol withdrawal syndrome, status epilepticus, & acute agitation-literature review.
Link:
#CritCareMed
@SCCM
#pedsICU
#ICUdelirium
1
61
100
Laryngeal injury common after prolonged mechanical ventilation, may contribute to post-intensive care syndrome with voice & breathing dysfunction
Shinn et al
Editorial : Revisiting the known unknowns.
@SCCM
#CritCareMed
0
62
101
#SCCM50years
#OpenAccess
@jlvincen
et al: Hemodynamic Monitoring and Support
Link:
@SCCM
@CritCareExplore
Fig: Timeline evolving techniques to estimate cardiac output
1
36
101
#SCCM50years
#OpenAccess
@AslaksonRebecca
et al: Prioritizing Compassion Within the ICU and Beyond
#palliativecare
#endoflifecare
#shareddecisionmaking
Link:
@PedCritCareMed
@CritCareExplore
@SCCM
@christopherecox
@JRandallCurtis1
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32
98
#FreeArticle
#SCCM50years
Bellomo et al: ICU-Based Renal Replacement Therapy
Link:
SCCM
#CritCareMed
Fig: Evolution of CRRT
2
40
98
Does the ABCDEF bundle make a difference to patient outcomes? 15,000 patients later, we know that it does.
0
76
97
#SCCM50years
#OpenAccess
@phil_dellinger
at al: The long and winding road of
#sepsis
investigations
⌛History
👭Societal impact
🔬Pathophysiology
🖋️Definitions
🧪Diagnosis
💊Management
🧑🤝🧑Patient experience
🛰️Future
Link:
@SCCM
2
33
97
Maves: Procalcitonin Is Not an Adequate Tool for Antimicrobial De-Escalation in Sepsis
Link:
#CritCareMed
@SCCM
#sepsis
2
41
95
#COVID19
#ONLINEFIRST
Iba et al: Severe
#ARDS
#COVIS
-19 induces microangiopathy & large vessel thrombosis in
#adultICU
pts.
- monitor D-dimer & fibrinogen
- DVT prophylaxis for all ICU pts
Link:
#CritCareMed
@SCCM
Fig: Thrombus formation in
#COVID
-19
0
61
92
#VisualAbstract
Gomez et al: Large vol resuscitation w' 5% alb + Saline vs 0.9 Saline alone
👉Retrospective study in 18,629 pts in 13 ICUs
⬇️ Mortality
No ⬆️ persistent renal dysfunction or ⬆️need for dialysis
Link:
#CritCareMed
@SCCM
@CCCNPitt
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41
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Check out the updated Surviving Sepsis Campaign evidence-based guidelines in
@CritCareMed
, which reflect best practices and recommendations for sepsis and septic shock treatment in adults.
@SCCM
#CritCareMed
#SurvivingSepsis
#CritCareExplore
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44
87
Herpich & Rincon: Concise review of state of the art of management of acute ischemic stroke.
Link:
#CritCareMed
#NeuroICU
#stroke
@SCCM
@askthebraindoc
Fig: Alberta Stroke Program Early CT Score for
#AIS
severity
2
34
80
Caught up in steroid controversy in septic shock? Read 3 viewpoints in
#CritCareMed
from investigators of ADRENAL, APROCCHSS & VANISH trials.
Russell et al: Toward Increased Understanding of Steroid Controversy in Septic Shock
Link:
@SCCM
#Sepsis
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52
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Methylprednisolone: Likely an Effective Treatment in Acute Respiratory Distress Syndrome
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44
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Nanchal et al : Executive summary: Guidelines for management of adult acute & acute-on-chronic liver failure in ICU: cardiovascular, endocrine, hematologic, pulmonary & renal considerations
Link:
@SCCM
#CritCareMed
#CCC49
Fig: Summary of Recommendations
0
42
78
#SoMe
team for
#CritCareMed
Plz follow to get latest updates on CCM
@chungk1031
@Paul_Wischmeyer
@ECMOdaily
@Bram_Rochwerg
@theABofPharmaC
@DavidKuICUMelb
@MarcKowalkowski
@PICU_UAE
@ABBCmd
@lingliu54014090
@ilanaPICUdoc
@aartisarwal
@PedCritCareMed
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35
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#VisualAbstract
Patidar et al: Maintaining a MAP>65 mm Hg may be a reasonable target in
#adultICU
patients with cirrhosis
Link:
#CritCareMed
@SCCM
#cirrhosis
#hepatology
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19
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Flannery et al: Sys Rev/Meta-Analysis of cont vs intermit vancomycin infusion
⬇️
#AKI
by 50%
⬆️ reach PK target
Link:
Editorial:
@AFlanneryPharmD
@BissellBrittany
@javo_neyra
#CritCareMed
@SCCM
Fig: Forest plot- AKI
0
38
74
Skrifvars et al: Early use of mannitol, but not hypertonic saline, independently associated w' ⬆️
#AKI
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Link:
#CritCareMed
@SCCM
Fig: Cumulative proportion of pts w'
#AKI
after day 2 indexed by early use of mannitol
1
42
75
Hayhurst et al: Hypoactive delirium in
#ICUsurvivors
, but not hyperactive delirium, leads to worse long-term cognition.
Link:
#CritCareMed
@SCCM
#ICUDelirium
#VisualAbstract
Fig: Hypoactive delirium duration vs global cognition
1
48
73
Nin et al: Humanizing ICU- We may not be able to cure all, but we can improve care, by listening more to pts & family members needs
Plenary
#CCC49
-Wed, Feb 19 •8:15 AM W Hall B4
Link:
@SCCM
#CritCareMed
@NinNicolas
@HUMANIZALAUCI
@MCMartinDelgado
2
44
73
#CCC50
#SCCM50years
Bellomo et al: ICU-Based Renal Replacement Therapy
-inception to technical evolution
-early application severe
#AKI
-large RCTs on clinical indications, dosage, & timing
Link:
#CritCareMed
@SCCM
Fig: Evolution
#adultICU
#CRRT
4
42
73
#SurvivingSepsis
Campaign: Guidelines on Management of Critically Ill Adults with
#COVID19
Panel of 36 experts from 12 countries
Applies to high & low-middle income settings
@CritCareMed
&
@yourICM
#OpenAccess
#CritCareMed
@SCCM
Link:
0
46
73
Breaking news! Post hoc analysis of the ATHOS-3 trial suggests that vasodilatory shock patients with acute kidney injury requiring RRT have a significant survival benefit from angiotensin 2. Read the paper here, now, for FREE.
3
57
70
Airway Pressure Release Ventilation as a Rescue for Acute Respiratory Distress Syndrome But Use Early to Prevent It!
0
32
72
Use of Vasopressor Increases the Risk of Mortality in Traumatic Hemorrhagic Shock: A Nationwide Cohort Study in Japan
5
44
69
TWO new systematic reviews on the use of procalcitonin to guide antibiotic use in confirmed or suspected sepsis. Here a link to the FIRST of these reviews:
2
68
70
The Cost-Effectiveness of Interventions to Increase Utilization of Prone Positioning for Severe Acute Respiratory Distress Syndrome
0
32
69
Current Issue: Propofol Related Infusion Syndrome: Ultrastructural Evidence for a Mitochondrial Disorder
0
58
65
Female Physician Leadership During Cardiopulmonary Resuscitation Is Associated With Improved Patient Outcomes*
2
50
65
Bonazzetti et al: Unexpected high frequency of ICU-acquired bloodstream infections in
#COVID19
pts
Link:
#CritCareMed
@SCCM
#sepsis
Fig: Cumulative bloodstream infections
#COVID_19
ICU pts
5
24
63
Ahead of Print: Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis
2
50
65
Gershengorn et al: Care by intensivists working fewer consecutive days is associated with reduced ICU length of stay without negatively impacting mortality
Link:
#CritCareMed
@SCCM
Fig: Association bw consec days worked and severity-adjusted ICU LOS
1
34
64
Lee et al: Improving oxygenation after 1st prone position >> significant survival predictor in mod-to-severe
#ARDS
Link:
Editorial:
#CritCareMed
@SCCM
Fig: Mean PF ratios during 1st prone
1
27
62
Defining the Role of Corticosteroids in Sepsis: Adjunctive Therapy for Shock Reversal
1
32
60
#FreeArticle
#SCCM50years
Chang et al: Evolution of Cerebrovascular Critical Care
#neuroICU
🧠
Link:
#CritCareMed
@SCCM
@neurocritical
Fig: evolution of
#stroke
care
3
22
60
The FDA approved Giapreza (Angiotensin 2). Read the latest safety information about this new agent for distributive shock, and share with your colleagues!
2
55
57
Further Considerations on the Benefits of Thiamine Administration in Patients With Septic Shock
0
20
58
Impact of Structured Pathways for Postcardiac Arrest Care: A Systematic Review and Meta-Analysis
0
36
59
June issue HIGHLIGHT- published in print
#SurvivingSepsis
Campaign
#COVID
-19 panel recomnedations for
#HealthCareheroes
=36 experts from 12 countries
Link:
#VisualAbstract
#Podcast
#CritCareMed
@sccm
0
37
58
#COVID19
#OnlineFirst
Maatman et al:
#AdultICU
#COVID
-19 pts develop venous thromboembolism with high incidence despite routine chemical prophylaxis
Link:
@TKmaatman
@traumamom4
@Dr_AMeagher
#CritCareMed
@SCCM
Fig: TEG in 12 pts w' severe
#COVID19
3
37
56
Steroid controversy in septic shock !
Annane : Why my steroid trials in septic shock were “positive”?
@sccm
#CritCareMed
#Sepsis
1
34
57
Counter point by Wischmeyer : Range of recent trials demonstrated safety & clinical outcome benefit of enteral feeding on vasopressors
Link:
@sccm
#CritCareMed
Fig : Evidenced-Based Methods to Address Enteral Nutrition Feeding Patients on Vasopressors
0
37
58
#VisualAbstract
#COVID19
Maatman et al: Routine venous thromboembolism prophylaxis may be inadequate in the hypercoagulable state of severe
#COVID19
Link:
#CritCareMed
@SCCM
0
44
57
Steroid controversy in septic shock
Gordon & Antcliffe : Why understanding sepsis endotypes is important for steroid trials in septic shock?
Link:
@SCCM
#CritCareMed
#Sepsis
1
30
56
Ahead of Print: Early Identification of Acute Respiratory Distress Disorder in the Absence of Positive Pressure Ventilation: Implications for Revision of the Berlin Criteria for Acute Respiratory Distress Syndrome
4
41
56
#VisualAbstract
@RachaelParke
et al: Multicenter RCT
#Fluids
after cardiac surgery evaluating SVV guided fluids vs usual care
715 pts in 5 ❤️ ICU in NZ
Link:
#CritCareMed
@SCCM
@eileengilder1
@mikegillham99
@ShayMcGuinness1
@CVICUResearch
1
18
55
Ahead of Print: Oxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomes in Acute Respiratory Distress Syndrome
5
38
55
#FreeArticle
#COVID19
Sprung et al: Who Will Live and Who Will Die? Practical guidance to front-line physicians forced to make critical rationing decisions.
Link:
#CritCareMed
@SCCM
@CharlesSprung
Fig: Objective tool to allow prioritization
0
40
55
Tierney et al Pulm
#ultrasound
can replace CXR using 9-pt lung US protocol vs CT in mech ventilated pts with acute resp failure
Link
@SCCM
#CritCareMed
#POCUS
@sunnydmtierney
Editorial:
Fig: Ultrasound & CXR zone location
0
29
55
Kayser & Kaplan : Conflict Management in the ICU
A concise review on origin, elements, causes, management and literature on conflict in ICU
Link:
#CritCareMed
@SCCMPresident
@SCCM
Fig: Conflict Trigger Matrix
0
24
54
Mauri et al: High variability in lung recruitment in
#COVID19
related
#ARDS
. Bedside recruitability estimates shld guide personalized mech vent
10 pts on vent Milan, Italy
Link:
#CritCareMed
@SCCM
Free Article
Fig: VQ mismatch elect impedance CT
0
29
53
Association of Driving Pressure With Mortality Among Ventilated Patients With Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis
3
35
53
#VisualAbstract
in ENGLISH, SPANISH, ARABIC & GERMAN
Hayhurst et al: Hypoactive delirium in
#ICUsurvivors
, but not hyperactive delirium, leads to worse long-term cognition.
Link:
#CritCareMed
@sccm
#ICUDelirium
#VisualAbstract
1
37
52
Mikkelsen et al: Recs from
@SCCM
consensus conf on
#PICS
prediction & assessment
👊 international experts in
#ICUrehab
#ThriveICU
#CritCareMed
research
Link:
Fig: Rec approach to functional assessments across
#ICUcare
continuum
0
17
52
Smith et al :
#MedEd
Critical care for med students. What do they need to know and do prior to entering residency?
Link:
@sccm
#CritCareMed
Fig : Highly Recommended Elements Grouped by Organ System
1
40
53
Santacruz et al : Systematic Review of 212 trials - Many RCTs showing decrease in mortality studied interventions that reduced iatrogenic conditions, notably in
#ARDS
rather than effect of a new therapy on mortality.
Link:
@sccm
#CritCareMed
#EBM
#RCT
2
31
53
👊2020 is almost done! Finish it strong with the last issue of the year📚
Check out articles on
#sepsis
#ARDS
#eICU
#biostats
#COVID19
#ABDCE
#ECMO
#neuroICU
#statusepilepticus
#pedsICU
#CoreOutcomeSet
#CritCareMed
#MedTwitter
@SCCM
0
9
51
Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults
1
33
52
Vasopressin didnt improve survival in cancer patients with septic shock as compared with norepinephrine: VANCS II RCT
Hajjar et al
Editorial : Match the right therapy to the right patient.
@sccm
#CritCareMed
#PrecisionMedicine
0
39
51
Revisiting
#VisualGraphic
2021
Liu et al: Simultaneous Use of Hypertonic Saline & IV Furosemide for Fluid Overload
Link:
#CritCareMed
@SCCM
0
18
51
Published Ahead of Print: Association of Driving Pressure With Mortality Among Ventilated Patients With Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis
1
45
51
Respiratory Variability of Pulmonary Velocity-Time Integral As a New Gauge of Fluid Responsiveness For Mechanically Ventilated Patients in the ICU*
0
27
50
Critical Care Ultrasound: A Systematic Review of International Training Competencies and Program
0
25
51
Effects of Fluid Bolus Therapy on Renal Perfusion, Oxygenation, and Function in Early Experimental Septic Kidney Injury
0
28
50
#VisualAbstract
Seelhammer et al: Comparison of Bivalirudin vs Heparin for Maintenance Sys Anticoagulation
#AdultICU
#pedsICU
#ECMO
Link:
#CritCareMed
@SCCM
#infographic
1
17
50
Cho et al : Neurocritical care for ECMO patients- addressing knowledge gaps & challenges in neurocritical care of ECMO patients
Link :
@sccm
#CritCareMed
0
25
48
View point by Arabi et al : Enteral Nutrition Should Not Be Given to Patients on Vasopressor Agents
Link:
@sccm
#CritCareMed
Fig : Suggested Approach to Enteral Nutrition in Patients on Vasopressor Agents
1
27
50
Stollings et al: Conducting high-quality interprofessional team rounds in the ICU is a key strategy to support ICU Liberation Bundle use
Link:
#CritCareMed
@SCCM
Fig: ICU interprofessional team deemed critical to execute delivery of
#ICULiberation
0
25
50
Johnson et al:
#TTM
for
#OHCA
at 33°C may have better neurological outcome compared w’ 36°C
Link:
@SCCM
#CritCareMed
@NickJohnsonMD
@Kyl_Dan
@crcounts
@Terri_Hough
@SayreMR
@hmcsepsis
Fig: Unadjusted Outcomes 33°C vs 36°C
1
30
50
Hypoalbuminemia and the Risk of Acute Kidney Injury in Sepsis
0
28
48
#SurvivingSepsis
#OpenAccess
@IshaqLat
et al: Fluid Resus & Vasopressor Therapy Research Priorities in
#adultICU
#sepsis
❓
- ideal endpoints
- optimal fluids
- optimal approach to selection, dose titration, & escalation
Link:
#CritCareMed
@SCCM
1
31
48
Revisiting
#Visualgraphic
2021
Dzierba et al: Discordance b/w respiratory drive & sedation Depth in
#mechvent
#adultICU
pts no
👎Sedation depth(RAAS) Not a reliable marker of resp drive (P0.1)
Link:
#CritCareMed
@SCCM
0
18
46
#FreeArticle
#COVID19
Sprung et al: Who Will Live and Who Will Die? Practical guidance to front-line physicians forced to make critical rationing decisions.
Link:
#CritCareMed
@SCCM
@CharlesSprung
Fig: Objective tool to allow prioritization
1
27
45
Wongtangman et al: Prolonged high % deep sedation >>
⬆️ mortality
#ARDS
pts NM blockers
7 ICUs New Eng Health Care Network
Link:
Editorial:
#CritCareMed
#neuroICU
#pharmaICU
@SCCM
@MatthiasEikerm1
Fig: Sedation vs mortality
2
23
46
Caring for Critically Ill Patients with the ABCDEF Bundle: R... : Critical Care Medicine. The Bundle saves lives. Will you adopt it in your hospital?
1
32
46
PODCAST on
#SurvivingSepsis
Campaign’s Guidelines on Management of Critically Ill Adults with
#COVID
-19
FREE ACCESS Article Link:
Guidelines are a joint collaboration
@SCCM
&
@ESICM
#CritCareMed
#sepsis
0
21
47
Public panel members shared their insights, advice &
experiences as pts/relatives informing 2021
#SurvivingSepsis
Guideline
#ICUrehab
#ICUsurvivors
#SepsisSurvivors
Link:
1
19
45
Videographics for increasing outreach of science in
#CritCareMed
@SCCM
#ARDS
phenotypes may offer prognostic enrichment
Article:
Video:
0
30
46
Should patients on vasopressors receive enteral nutrition?
@YaseenarabiYa
&
@Paul_Wischmeyer
each present their case for giving, or not giving enteral nutrition in ICU
Register:
@SCCM
#CritCareMed
1
21
46
#COVID19
#OnlineFirst
Maatman et al:
#AdultICU
#COVID
-19 pts develop venous thromboembolism with high incidence despite routine chemical prophylaxis
Link:
@TKmaatman
@traumamom4
@Dr_AMeagher
#CritCareMed
@sccm
Fig: TEG in 12 pts w' severe
#COVID19
3
29
45
Robba et al: Acute kidney injury after traumatic brain injury: prevalence, risk factors, associations & impact
65 European ICUs
4509 pts w'
#TBI
Link:
#CritCareMed
#neuroICU
@SCCM
@Dr_Cit
@chiara_robba
@GMeyfroidt
Fig: Transition probabilities
0
21
45
Association Between Elevated Mean Arterial Blood Pressure and Neurologic Outcome After Resuscitation From Cardiac Arrest: Results From a Multicenter Prospective Cohort Study*
1
28
45
Santoro et al: HOPE-COVID19 study
Anticoagulation therapy in general
#COVID19
population was not associated w' better survival rates but w' higher bleeding risk.
Link:
#CritCareMed
@SCCM
Fig: Rates of occurrence of death and bleeding
1
34
45
Corticosteroids in Sepsis: Clouded by Heterogeneity
0
21
44
Zou et al: APACHE II score was an effective clinical tool to predict hospital mortality in pts with
#COVID19
compared with SOFA score & CURB65 score.
Link:
#CritCareMed
@SCCM
#FREEarticle
Fig: ROC -predictive value of APACHE II, SOFA & CURB65 scores
0
21
44