ASHansen Lab
@hansen_lab
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We seek to understand the molecular mechanisms that regulate genome organization and gene expression in time and space. Based in @MITdeptofBE
Cambridge, MA
Joined August 2019
The @Anders_S_Hansen Lab find tiny loops in the genomes of dividing cells. Enabled by a new high-resolution mapping technique, the findings overturn a long-held belief that the genome loses its 3D structure when cells divide. @NatureSMB
https://t.co/t5Zc0nCvgx
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Jamie Drayton and I were fortunate to contribute RCMC to this beautiful paper from Eder, Moene...van Steensel that systematically maps the relationship between enhancer location and gene expression (and nice to see RCMC predict expression in Fig 2H-I): https://t.co/FwU5MaRLwW
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Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin. STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation. https://t.co/DDjriqPFKE
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Who's up at BATS? @VarshiniRam23 (@hansen_lab @Anders_S_Hansen): “3D Genomic Mapping Across Human Erythropoiesis” https://t.co/UUBCQauu8x
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Congratulations to Dr. Viraat Goel and Dr. Domenic Narducci, both new PhDs in Biological Engineering from the lab!
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(1/13) Thread on @mazzocca_matteo @DomenicNarducci @SGrosseHolz @_jessematthias new preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide some answers https://t.co/5BgjT7ujcO
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(1/n) New preprint from @claricehongky Fan Fang @VarshiniRam23 in collab w Jie Liu Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps https://t.co/Wf7tppUk2p
Excited to share my first preprint from @hansen_lab! It's got genomics, AI, and biology - all wrapped up in a great paper. Also very grateful to my amazing collaborator, Fan, for all his hard work. Please check it out and let me know what you think! https://t.co/enkF9fUF9M
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Check out Masahiro Nagano's preview https://t.co/I37WuLUtKK of a very cool paper from Tjalsma...Wouter de Laat: https://t.co/YG81dyMP6f
Distance matters: How protein regulators facilitate enhancer-promoter interactions and transcription
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Mostly on BlåSky but excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we perform absolute quantification of looping (e.g. this loop is present 3%). We quantify mESC 36k loops: <loops> are generally rare (2.3%). https://t.co/XmpmWHV66O
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Our preprint by @DomenicNarducci and the companion preprint by @deWitLab are now out in @MolecularCell ZNF143 is not a general looping factor and was identified as such due to a non-specific antibody. Instead it is TF with the longest residence time measured (to our knowledge)
(1/14) Excited to share our new work on ZNF143/ZFP143 by @DomenicNarducci ZNF143 has been widely reported to be a general loop factor Instead we and @deWitLab in a companion preprint show that ZNF143 is a TF with no loop function: https://t.co/kqvujLFjEN
https://t.co/UJD9mNKcWq
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Very grateful to @NIH_CommonFund for funding our Transformative Research Award #NIHHighRisk
#NIHHighRisk Transformative Award recipient Dr. Anders Hansen of @MITdeptofBE will be exploring how transcription factors find their target cites in synthetic and #CancerBiology
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Congrats to @ViraatGoel James Jusuf et al. on new preprint in collab with @Irate_Physicist @blobelgroup @leonidmirny discovering transient microcompartments that connect enhancers and promoters in mitotic chromosomes:
biorxiv.org
As cells exit mitosis and enter G1, mitotic chromosomes decompact and transcription is reestablished. Previously, Hi-C studies showed that essentially all interphase 3D genome features including...
(1/n) From @ViraatGoel @Irate_Physicist et al. collab w @blobelgroup @leonidmirny
https://t.co/CdI7n2P31a RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry Sims reveal chromosome compaction as key regulator
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Come and see James' BATS talk today
First BATS of the academic year 2024/25 🥳! James Jusuf (@hansen_lab): “Genome-Wide Absolute Quantification of Chromatin Looping” https://t.co/cl8idnM5ja
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Congrats to @GavinSchlissel @Pulin_Li with single-molecule imaging contribution from @DomenicNarducci @hansen_lab Single-molecule imaging of hedgehog in morphogen gradients reveals a surprisingly complex diffusion mechanism: https://t.co/Byzkemhgvv
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Congrats to @ngaboreden @blobelgroup with RCMC contribution from @ViraatGoel @hansen_lab . Having recently worked on what we thought was a looping factor (ZNF143 https://t.co/ltSEKYv3TG ) it was amazing to work on a strong Enh-Promoter looping factor LDB1 https://t.co/YR5gYcxNjS
Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks and can function independently of cohesin!
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Bittersweet to say goodbye to Christos last week - Thanks for 2 fantastic years and all the best for grad school at Columbia!
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Congrats to Ava @AvaConyer on a fantastic MSRP poster presentation on the polycomb work she did together with Sumin @suminkim28 !
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Excited to welcome Jacob @Kaestelhansen as a new Novo Nordisk Foundation post-doc to the lab!
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