Matteo Mazzocca
@mazzocca_matteo
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Postdoc @hansen_lab | PhD Davide Mazza Lab @MyUniSR | 3D genome, TFs, gene regulation
Cambridge, MA
Joined October 2022
1/.Super excited to share my first preprint from @hansen_lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
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RT @Anders_S_Hansen: (1/13) Thread on @mazzocca_matteo @DomenicNarducci @SGrosseHolz @_jessematthias new preprint. Q: how does chromatin mo….
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5/.This was a true team effort with @DomenicNarducci, @SGrosseHolz, @_jessematthias & @Anders_S_Hansen. I’m grateful and proud to have worked together. And huge thanks to @AICF_nyc for their fellowship support. Check out the preprint:
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4/.However, as distance increases search times become progressively more challenging. At ~1µm (1-3 Mb), EP can take ~5-24 h to randomly find each other – potentially too long for a cell cycle → distant EP need help (e.g. loop extrusion).
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3/.We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
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2/.Such fast and long chromatin tracking is key to understanding how distal genomic elements (e.g. enhancers and promoters – EP) find each other. We found chromatin is highly subdiffusive (α ~ 0.3) -> loci are great at exploring the neighborhoods but rarely reach distant regions
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RT @Anders_S_Hansen: (1/n) New preprint from @claricehongky Fan Fang @VarshiniRam23 in collab w Jie Liu. Q: How do we get ultra-high-res 3D….
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RT @claricehongky: Excited to share my first preprint from @hansen_lab! It's got genomics, AI, and biology - all wrapped up in a great pape….
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RT @labronic_mike: 📷.📢 New Lab Alert! .I am very excited to share that starting this summer, I will open my laboratory at the San Raffaele….
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RT @Anders_S_Hansen: Check out Masahiro Nagano's preview of a very cool paper from Tjalsma. Wouter de Laat: https:….
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RT @nevillesanjana: 🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab. 🎇🎄. In this work, superstar postdoc @Xu….
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RT @Anders_S_Hansen: Our preprint by @DomenicNarducci and the companion preprint by @deWitLab are now out in @MolecularCell . ZNF143 is not….
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RT @shiner80: We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this,….
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RT @BintuLacra: A dream come true: in 2004 I started thinking about counting microstates to predict gene expression with @JKondev Rob Phill….
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RT @Anders_S_Hansen: Come and join us!.We are looking to recruit a Research Assistant/Technical Associate I to join our team Summer 2024.….
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I’m excited to share that my PhD paper is now published in @NatureComms! I’m grateful for the support of all collaborators, in particular my advisor @shiner80, Alessia Loffreda, and Emanuele Colombo. See this thread for more details, and read the paper at
. And the manuscript is now out in @NatureComms: Here a long-due but (hopefully) short thread:.
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RT @micheleboldrin: Chiedetemi se sono sorpreso. Chiediamo a @GiorgiaMeloni di revocargli la delega alla sanita', questi comportamenti led….
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RT @tinekelenstra: Ever wondered how transient transcription factor DNA binding can robustly activate transcription? In this new preprint,….
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