Guillaume Andrey
@guillaumeandrey
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Assistant Professor @unige_en trying to link chromatin biology and morphogenesis
Genève, Suisse
Joined June 2012
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @BompadreOlimpia, to Marie Kmita's lab, and to all the co-authors.
nature.com
Nature Communications - Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in...
Our #preprint on Pitx1 & Liebenberg syndrome with @BompadreOl98894 is out. Key findings:.Phenotypic severity tied to proportions of Pitx1 overexpressing cells, not transcription level. Pitx1 transcription doesn't drive enhancer-promoter interactions. 1/X.
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RT @horizons_en: Studying the effect of mutations in embryos without ignoring the questions raised by animal experimentation. Interview wit….
horizons-mag.ch
Guillaume Andrey studies embryonic development and deformity. He has also been recognised for his efforts to reduce the number of mice sacrificed in the name of science.
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RT @aimeezun: Very excited to share our latest work in @NatureComms where we identify two limb mesenchymal progenitor populations involved….
nature.com
Nature Communications - The initial cellular alterations underlying changes in digit numbers and identities were unknown. Here, Palacio et al. identify two limb bud progenitor populations that are...
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RT @Katrinardottir: I'm very excited to share that I’ve started as a group leader @karolinskainst. I am looking for curious, enthusiastic a….
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RT @m_osterwalder: It's a great pleasure that our study about the regulatory role of the Shox2 gene desert – a non-coding genomic region wi….
nature.com
Nature Communications - Approximately a quarter of the human genome consists of gene deserts. Here, Abassah-Oppong et al. reveal the biological relevance, embryonic functions and underlying...
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RT @ElphegeNoraLab: First preprint from the lab 🚨. How can enhancers regulate target promoters across vast genomic distances, and what is t….
biorxiv.org
Enhancers are critical genetic elements controlling transcription from promoters, but the mechanisms by which they convey regulatory information across large genomic distances remain elusive. Here,...
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RT @GJuliane_: 🚨Preprint alert🚨 Excited to share the #preprint version of our work @MundlosLab ! Curious about how a transposable element (….
biorxiv.org
Mammalian genomes are scattered with transposable elements (TEs). TEs are epigenetically silenced to prevent harmful effects caused by either global activation leading to genome instability or...
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RT @SedonaMurphy: I'm excited to share this collaborative work with @KraftKaterina and @MattG_Jones that started as an exploration of the….
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RT @ClaudioCantu81: We present.The Transcription Factor Binding Landscape of Mouse Development🐭🧬 #DevBio. We use CUT&RUN-LoV-U to map .Many….
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RT @RealFany: Super happy to get my first Spanish national grant!!! Plus one extra PhD contract! 🥳🥳🥳 Reach out to me if you want to join th….
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RT @PGuckelberger: I am so excited to share this part of my PhD where we tackle the question: What impact do 3D contacts have on how enhanc….
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RT @Duboule: Hoxb13 and the control of body length, with #gastruloids to the rescue and #CTCF as heterochronic factors🕰️now in @biorxivprep….
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RT @AnnaRamisch: So happy that our preprint is finally out! If you're interested in the advantages of long-read direct RNA sequencing in po….
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RT @CanAztekin: 🎉🎉🎉New preprint alert! 🎉🎉🎉 .We present our deconstructed approach to studying limb development and regeneration-related cel….
biorxiv.org
Specialized signaling centers orchestrate robust development and regeneration. Limb morphogenesis, for instance, requires interactions between the mesoderm and the signaling center apical-ectodermal...
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RT @evgenykvon: The Kvon lab is hiring a postdoc. We developed lots of powerful in vivo tools to address exciting questions in gene regulat….
kvonlab.org
The Kvon Lab at UC Irvine. Regulatory Genomics, Enhancers, Evo-Devo
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Fine tuning the cellular abundance of each subunit of the SWI/SNF complex is essential for the adequate opening of #enhancers and #promoters. Beautiful work from our next door colleagues.
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RT @UNIGEnews: Des scientifiques de l’#UNIGE ont identifié les séquences génétiques régulant l’activité des gènes responsables de la croiss….
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Here, four enhancer deletions result in decreased transcription of their cognate genes. Notably, a single enhancer deletion at Fgfr3 leads to a 70% transcription loss in the trunk and limbs.
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