MundlosLab
@MundlosLab
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Bio - logy. Mutations, TADs, and gene regulation in development. All the good stuff. Tweets by @mphan_236 and lab members.
Berlin, Germany
Joined January 2015
How to make a bat wing🦇? Check out the latest #evodevo preprint from the Mundlos Lab at @MPI_MolGen together with @RealFany and @Dariloops, led by our very own @M_Schindler_ and @ChrisFeregrino! https://t.co/ePMRiTFfTX See the thread for more 👇
biorxiv.org
Bats are the only mammals capable of self-powered flight, an evolutionary innovation based on the transformation of forelimbs into wings. The bat wing is characterized by an extreme elongation of the...
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(1) Chromatin/cancer paper alert! We've unraveled how genotoxic anticancer drug impacts the chromatin structure of human cells. Using Hi-C, ChIP-seq, and RNA-seq, we've explored the changes in chromatin architecture triggered by doxorubicin and ICRF193.
mdpi.com
In this study, we delve into the impact of genotoxic anticancer drug treatment on the chromatin structure of human cells, with a particular focus on the effects of doxorubicin.
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Excited to share our story on how enhancers repositioning leads to disease-associated gene mis-expression during development out in @NatureComms 🧬🐁🤓 I couldn't be happier to have teamed up with @Giulia_Cova on this one! @MundlosLab 👇
And it’s officially out @NatureComms!!Couldn’t be happier 😃🥳!! A long way, but definitely worthy!!Thanks to my amazing partner-in-crime @GJuliane_ 🤗, all the authors, the reviewers, and to everyone that has been part of this journey 🤗 so grateful!!
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And it’s officially out @NatureComms!!Couldn’t be happier 😃🥳!! A long way, but definitely worthy!!Thanks to my amazing partner-in-crime @GJuliane_ 🤗, all the authors, the reviewers, and to everyone that has been part of this journey 🤗 so grateful!!
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🧬 Want to dissect the gene regulatory function of long non-coding RNAs using #genomicengineering #syntheticbiology? Join the lab of @StefanMundlos / @MundlosLab & our #IMPRS-BAC #gradschool! Apply today! 👉
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Researchers @MeloUira @StefanMundlos @MundlosLab @VingronLab characterize structural variations (SVs) in a cohort of individuals with complex genomic rearrangements and investigate their impact on gene expression and the 3D chromatin architecture. https://t.co/Vdv2H5iUTV
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Way to go! Congrats @Alessa_Ringel 🥳🥳🥳
Last week we hosted the GOA Young TAD Award presentations. They were all amazing and the scoring was very tight! We are excited to announce the winner was @Alessa_Ringel 👏👏👏
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🦔 Looking for a #PhD position & interested in investigating how the hedgehog got its spines? Join the lab of @StefanMundlos / @MundlosLab & our #IMPRS-BAC #gradschool! Apply today! 👉
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We are happy to share the latest work from @MundlosLab published on @NatureComms We combined short- and long-read sequencing in samples with germline complex genomic rearrangements.
nature.com
Nature Communications - Here the authors characterize structural variations (SVs) in a cohort of individuals with complex genomic rearrangements, identifying breakpoints by employing short- and...
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Interested in gene regulation in disease? Stay tuned for @mrmikerobson1´s lab opening @BIMSB_MDC in April 2023.
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The latest Mundlos lab evolutionary adventure in gene regulation continues.. Big congratulations to @Alessa_Ringel & @mrmikerobson1! Check out the tweetorial for the highlights ⬇️
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Job alert Postdoc: you are a molecular biologist and interested in gene regulation? Study how lncRNAs work in regulating genes in development. Use cutting edge technologies including synthetic genomics and large-scale genomic engineering. Contact me.
molgen.mpg.de
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Congrats everyone, especially our very own @KraftKaterina & @Andreas_Magg 🍾🥂 A must-read for all 3D- & Polycomb-enthusiasts!
Thank you @KatieEYost @HowardYChang @SedonaMurphy @Andreas_Magg @YichengLong @ABoettiger @StefanMundlos Tom Cech Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation | Proceedings of the National Academy of Sciences
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Thanks so much to everybody for support in this #ERCAdG endeavor! It has been a tough competition. I see it as a special honor that my project was viewed as "ostentatiously overambitious" by a reviewer. Peer reviews are so much fun! 😂
🍾 Congratulations! 🎉 For a a research project on the genomics of evolution, or “how bats learned to fly”, our researcher @StefanMundlos / @MundlosLab has been awarded a prestigious @ERC_Research Advanced Grant #ERCAdG
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🍾 Congratulations! 🎉 For a a research project on the genomics of evolution, or “how bats learned to fly”, our researcher @StefanMundlos / @MundlosLab has been awarded a prestigious @ERC_Research Advanced Grant #ERCAdG
molgen.mpg.de
Berlin researcher Stefan Mundlos has been awarded a prestigious ERC Advanced Grant. The funding program of the European Research Council (ERC) is one of the most distinguished in Europe. Mundlos...
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Anlässlich ihrer Jahresversammlung zeichnet die Leopoldina ForscherInnen für ihre hervorragenden wissenschaftlichen Leistungen aus. Mehr: https://t.co/uspvIGSWs7
@CoBaStiftung
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I am excited to announce the publication of TADA, a tool to prioritize pathogenic CNVs @GenomeBiology! TADA annotates CNVs with respect to the affected regulatory environment and computes a pathogenicity score indicating their functional impact. https://t.co/pjfiev8d5r
genomebiology.biomedcentral.com
Few methods have been developed to investigate copy number variants (CNVs) based on their predicted pathogenicity. We introduce TADA, a method to prioritise pathogenic CNVs through assisted manual...
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@Giulia_Cova is now a post doc in NYC @nyulangone. Feel free to reach out to her if you have any questions!
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Check out our new @biorxivpreprint! A bona fide Mundlos Lab's study looking at structural variations leading to gene dysregulation @ the Lbx1/Fgf8 locus. An impressive effort lead by @Giulia_Cova & brought to the finish line by @GJuliane_ #preprint #3DGenome
Extremely happy to share the preprint of my work from my time in the @MundlosLab! A novel conceptual framework where combination of gene misexpression and dosage occurs upon structural variations that involve the Lbx1/Fgf8 locus and its 3D organization.
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🦇 Join the lab of @StefanMundlos / @MundlosLab / @der_bri to find out how bats learned to fly! To uncover the complex changes in its genome, apply as a #PhD student & join our #IMPRS-BAC research school! 👉 https://t.co/CfXXtFSOJL
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