Super neat use of nanobody generation!

Breaking news: MIT’s president turned down the Trump administration’s offer of priority access for federal funding, publicly releasing a letter that emphasized the elite university’s values.

Congrats to Mary Brunkow, Shimon Sakaguchi & PICI scientific advisor & former CSO Fred Ramsdell, for receiving the @NobelPrize for their work on peripheral immune tolerance. This recognition reinforces why deep study of the immune system remains central to scientific progress.

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Review @NatRevImmunol Regulators of CD8+ T cell exhaustion https://t.co/JF3pDpd9Ym

Excited to share this work from my PhD! See our structure below of a computationally designed IL-21 mimic with anti-tumor efficacy in mice. A collaboration between the David Baker, Stephanie & Mike Dougan, Warren Leonard, and Chris Garcia labs.

Scientists have designed an interleukin-21 mimic with increased stability and capacity to induce more potent #antitumor activity than the native protein, which could inform improved #immunotherapies. @UWproteindesign Learn more in Science #Immunology: https://t.co/WR1foQx6Mq

The US president repeatedly advised people, “Don't take Tylenol,” but scientists say that strong evidence between the medication and autism is lacking https://t.co/yNhKXkSFrB

Grateful to share that my postdoc training continues with the support of the Mechanisms & Innovations in CVD T32 Grant from @StanfordCVI! Just attended the Immuno-Cardiology Symposium at @jacksonlab & @MDIBL in Bar Harbor and am excited to apply protein engineering to the field.

Tumors often metastasize to lymph nodes before distant sites, yet evidence suggests that distant mets can originate from unique clones. Is this divergent seeding random? No. Check out our newest @biorxivpreprint to learn how the mechanisms diverge and how to harness them for IO.

Check out this preprint from @CortBreuer and @RetickerFlynn - always grateful for the opportunity to collaborate with them as they uncover the methods and molecular basis of metastasis!

I’m excited to share the first major story from my PhD today on the complex role of type 1 interferon in metastasis and immunotherapy! This work was made possible with the support of @RetickerFlynn, Marcos Labrado, and the incredible protein engineer @grayerodriguez

Amazing plasticity in T cells revealed through synthetic biology. Bold science spearheaded by my friend @YangZhao102 and co-led by @xrtcell and Chris Garcia. Huge congrats to Yang and the team!

Excited to share our @Nature papers exploiting the receptor pairing code to expand the cytokine receptor alphabet in T cells. Nonnatual receptors reprograms T cells into myeloid lineage. Grateful for the amazing collaborators @xrtcell , @MasatoOgishi

Pleasure to share a tremendous body of work from @YangZhao102, who led the next chapter of the powerful orthogonal IL-2 technology from the Garcia Lab (where the innovative spirit is unmatched). Grateful for this ongoing collaboration, stay tuned for more.

🚨More cytokine-signaling magic from the @xrtcell and Garcia labs. Non-natural signal pairing with the common gamma chain receptor can drive unique transcriptional programs in T cells. 🤯This includes induction of phagocytic T cells by pairing with GSCFR!!

Expanding the cytokine receptor alphabet reprograms T cells into diverse states @Nature #GarciaLab @xrtcell https://t.co/z8b3ckEIm7

An incredible follow up to the Garcia Lab ortho-IL-2 receptor system published in @Nature today led by @YangZhao102. It's been an honor learning from Yang and co-authors in the process of bringing this project to fruition. A tour de force- check it out!

Congratulations to @CortBreuer on his first author article in @NatureProtocols out today! It was neat learning more about the model while working together. The @RetickerFlynn Lab is the place to go for these metastatic models.

Excited to see our protocol out today on spontaneous and experimental models of LN metastasis in @NatureProtocols! Though a straightforward system conceptually, getting these models working reliably took more time than originally expected so I hope this is a resource to everyone.