Ginny Farias
@ginny_farias
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PI, Cell biologist loving neuronal morphology, organelle dynamics & inter-communication, polarized protein trafficking and more...
Utrecht, Netherlands
Joined May 2014
Secretome translation shaped by lysosomes and lunapark-marked ER junctions https://t.co/BVWbFONE0T
nature.com
Nature - Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes,...
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Many thanks to Amelia Glazier and The Journal of Cell Science for including me in ‘First Persons’ through the decades – 100 years of notable scientists in The Journal of Cell Science https://t.co/ZjrhEqV92Z Happy to be in such great company!
journals.biologists.com
Summary: JCS highlights the lives and careers of 10 notable scientists from around the world who published first author papers in our journal over the last 100 years.
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Endoplasmic reticulum junctions serve as a platform for endosome-lysosome interactions through their stop-and-go motion switching | Science Advances
science.org
ER junctions coordinate endosome-lysosome interactions by regulating their stop-and-go motion for precise cargo exchange.
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Proud of my PhD student Ha Nguyen that presented a poster of her preprint and got 1st place :) Congrats, Ha!
New preprint from the lab. Amazing work from Ha Nguyen, PhD student in our lab. Thanks to collaborators! See thread 👇
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This is going to be a very exciting meeting! Registration is now open. 🔬🌈🧫
Registration is now open to attend @J_Cell_Sci's meeting on Imaging Cell Dynamics, to be held in Spain in 2026 and organised by @Fran_Bottanelli, Guillaume Jacquemet, Giulia Zanetti & @DrMichaelWay. Find out more and apply to attend at https://t.co/YQmS6oU6Dk
#JCSimaging
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HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs | bioRxiv
biorxiv.org
Amyloid precursor protein (APP) is a key player in various neuronal functions but also the source for toxic Aβ that accumulates in the brain of Alzheimer patients. APP trafficking and processing...
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Check out our new preprint from the Farias & Klumperman labs about the role of HOPS in APP trafficking and processing. Thanks to collaborators! See 👇
I am happy to share our work on the role of the HOPS complex in APP trafficking and processing! 💫 Out now on bioRxiv: https://t.co/AAwLzQEEEo
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New preprint from the lab. Amazing work from Ha Nguyen, PhD student in our lab. Thanks to collaborators! See thread 👇
Excited to share our preprint, now available online on BioRxiv! https://t.co/LjayTn0d6b. We uncovered the coupling of translation and secretion machineries at the #axonalER to promote local delivery of axonal transmembrane proteins (TMPs) to the plasma membrane.
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4Pi-SMS and pan-ExM reveal, in a close collaboration with the Rothman lab, a surprising tetraplex organization and self-assembly of rim golgins, which we believe can explain stack formation of the Golgi apparatus: https://t.co/lxWaoCSN8T
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Target ALS is now accepting proposals for a new funding opportunity to accelerate the discovery of novel, biologically rational therapeutic targets for ALS. LOI due 6/17/25. Learn more and apply: https://t.co/ksPrFXyOk5
#ALS #ALSResearch #FundingOpportunity
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Really interesting plant work in @Dev_Cell examining ER sub-domains where peroxisomes and lipid droplets bud. https://t.co/TZKAekPMeu
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New study by Luján et al. from Vivek Malhotra's group @CRGenomica ( https://t.co/UQNj3mWYin) details the molecular mechanism of a rare illness that causes transient paralysis and dangerous arrhythmias. More in the news @elpaisinenglish:
english.elpais.com
A team from the Center for Genomic Regulation in Barcelona details the molecular mechanism of a rare illness that causes transient paralysis and dangerous arrhythmias
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Happy to see our POTATOMap tool & story about biosynthetic LAMP trafficking published. Tool in addgene, proteomic raw data available. See 👇
https://t.co/YKn0ER4z5v POTATOMap is officially out today (even tho it says 2024-12-30)… long story 😂 Constructs are available on addgene and POTATOMap data is available on PRIDE repository. Thank you so much to everyone involved!!
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ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
https://t.co/ukJcD7aZsE
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A nice story from @JKlumperman lab. Role of Vps41 in the recruitment of biosynthetic LAMP. Check out 👇
Sanzà, Klumperman et al. @UMCUtrecht reveal a novel role of VPS41 in cellular trafficking, showing that it recruits biosynthetic LAMP carriers in a process dependent on the small GTPase Arl8b. https://t.co/3iyg6XcN77
#Organelles #Trafficking
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Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43 ribonucleoprotein condensates disrupting mRNA transport and local translation in neurons
cell.com
Wijegunawardana et al. demonstrate that Ataxin-2 intermediate-length polyQ expansions disrupt TDP-43 motility and condensate dynamics, impairing mRNA localization and local translation in primary...
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PhD student: "please don't be excited yet, these are just preliminary results, I still need to repeat the experiment multiple times" PI: https://t.co/bD6KrCqMpo
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Proteins are the building blocks of life, but did you know a single neuron contains billions of them? Discover the incredible diversity and complexity of proteins in our neurons, and how they shape brain function, in our latest explainer film with the Brain Prize winners of 2023.
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Exciting Traffic and Membrane contact seminars coming up this Thursday details of how to join below: https://t.co/IIQ5CoXuUr
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Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy https://t.co/yFfaGZ12H8
nature.com
Nature Communications - Unconventional protein secretion emerges as an important mechanism in aggregate-prone protein removal. Here, the authors demonstrate that Plekhg5 mediates the unconventional...
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