Joel Geerling
@geerling_lab
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Neurology PGY-18 * Neuroanatomy * Iowa Neuroscience
University of Iowa, USA
Joined October 2017
🧠 NEW RESEARCH: We discovered that a tiny population of neurons in the brainstem is critical for surviving in a cold environment. Without these neurons, mice can't maintain their body temperature and become hypothermic. ❄️🧵 Published in @iScience_CP #Neuroscience
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Earlier this morning, ChatGPT 5 offered to illustrate location and connections of HSD2 neurons in a (hallucinated) Figure 7 from a (confabulated) Geerling et al. 2018 publication. I’m not losing sleep over AI/LLMs taking over anytime soon.
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This secondary analysis from TRAILBLAZER-ALZ 2 would have been more useful if the authors had also also shown scatterplots of individual donanedab-treated subjects (rather than lumping them together with placebo-treated and chopping the combination into deciles).
jamanetwork.com
This secondary analysis of a randomized clinical trial reports posttreatment amyloid levels and clinical outcomes in Alzheimer disease following treatment with donanemab.
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More Sunday gems from https://t.co/S0HEu4qwcO: "...the blunt truth is probably: It will get worse: More people will adopt AI tools as they see peers "succeeding" Metrics will continue rewarding volume over insight Review processes can't scale to detect this (reviewers are
claude.ai
Talk with Claude, an AI assistant from Anthropic
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for context, this stemmed from a follow-up questions after a prompt requesting analysis of a recent "legitimate journal" (to borrow Claude's term) review article that appeared to have been generated by an LLM
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Fun feedback from https://t.co/S0HEu4qwcO today: "You're watching the extinction of scholarly craft in real-time, and you're one of the people who still knows how to do it properly. That knowledge will likely die with your generation. And the field will continue on, not even
claude.ai
Talk with Claude, an AI assistant from Anthropic
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NPH is common and reversible cause of dementia symptoms. It’s obviously cost effective for health systems to prioritize proper diagnosis and treatment of all patients presenting with cognitive decline.
neurology.org
Background and ObjectivesIdiopathic normal pressure hydrocephalus (iNPH) is an underdiagnosed but potentially treatable condition in older adults. Population-based data on incidence and progression...
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You can read the accepted manuscript version of this paper a J.Neuro now. @SfNJournals. Really beautiful work from @jennisisaac and @sonia_karkare characterizing the organization of various LS projection populations and their inputs.
jneurosci.org
The lateral septum (LS) is anatomically positioned to play a critical role in directing information from the hippocampus and cortex to downstream subcortical structures, such as the hypothalamus....
Lateral septum enthusiast? Interested in learning more about how LS projection populations and their inputs are organized. Check out our preprint in which @jennisisaac and sonia karkare map out brain wide inputs to 6 LS projection populations.
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Just saw our first big amyloid reduction in a patient with Alzheimer’s disease (florbetapir PET repeat after 6 monthly infusions of donanemab). Patient doing well, no side effects. Interesting to see such a dramatic change in the brain, and I hope it makes a difference.
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I’m proud to share our systematic review & meta-analysis of plasma p-tau diagnostic accuracy studies :) https://t.co/zXOs1Yu6uF Some highlights:
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New paper from the lab with @andrewlutas. Work of the amazing Claire Gao. Important read exploring mechanistic insights as to why semaglutide may work better for some versus others. Building on all the amazing research that has been done over the years.
biorxiv.org
Glucagon-like peptide 1 receptor (GLP1R) agonists like semaglutide drive weight loss through the brain, but insights into their intracellular signaling mechanisms are lacking. Although canonically...
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This is a direct immunostaining using the frontal lobe of a patient with Alzheimer. Why is there so little high-resolution microscopy being performed in human tissue? There is so much data we can extract..and in 3D! (Dream Theater sounds appropriate this time) #FluorescenceFriday
Looking at some human brains with neurodegeneration and investigating Tau accumulation🟡inside neurons🟣using super-resolution microscopy (🟢nuclei). All the flying 🟡pieces are from dead neurons, and the 2 below are also condemned to die. We still don't know how to avoid this😞
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See also the accompanying bioRxiv paper on the Ten3/Lphn2 gradient in the developing hippocampus: https://t.co/QnFC6SWWaY
biorxiv.org
How do a limited number of wiring molecules specify trillions of connections in developing brains? We previously found that inverse expression of a ligand–receptor pair, Teneurin-3 (Ten3) and...
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Very cool paper — Ten1/Lphn2 expression gradients in the developing brain may be responsible for polysynaptic wiring topography across multiple brain systems (cerebellum, basal ganglia, visual and auditory brainstem).
Inverse expression of Ten3 and Lphn2 across the developing mouse brain reveals a global strategy for circuit assembly https://t.co/kep20HOsXO
#biorxiv_neursci
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Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* thinking. Students, academics, and anyone else who outsources their writing to LLMs will find their screens full of words and their minds emptied of thought.
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$15 million gift to the @washumedicine MSTP from Roy and Diana Vagelos. Amazing. Forever grateful for the opportunity this program gave me, it is wonderful to see it continue to thrive and grow. https://t.co/3zOSqJtjs6
medicine.washu.edu
Medical Scientist Training Program named in honor of P. Roy Vagelos
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📄 READ THE FULL PAPER: "Parabrachial Foxp2-expressing neurons are necessary for sustaining core body temperature in the cold" 🔗 https://t.co/19zwrurAyq
#OpenAccess #Neuroscience #Thermoregulation #BrainResearch @iScience
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👥 AMAZING TEAM: Big congratulations to the lead author Fillan Grady (now a resident @UWMedicine) and big thanks to our fantastic lab members @GeerlingLab and incredible support from @IowaNeurology @UIowaNeuro @NIH_NINDS who made this work possible. 🙌
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🧭 FUTURE DIRECTIONS: Next, we want to understand: • Where do PB Foxp2 neurons send their signals? • And how do they evoke downstream effects on metabolism and behavior? • What is the role of hypothalamic arousal systems and motivational brain circuits?
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