Patrick knew what was important, he kept everyone in touch, be it in his Christmas for non-Christians, overnight smoking affairs, or just for cocktails; it was always at Patrick’s house where I saw everyone that I had not put the time in seeking out. Patrick will be sorely missed

I want to take a moment to remember Patrick McDonel who passed yesterday. I owe much of the fun things I do in science to Patrick McDonel. He taught me to think about molecular biology and instilled the ethos of my lab. Join mein keeping his memory.

Here's Ramanujan using social media ca. 1913. Fortunately the recipient read the letter and replied.

Welcome @ViaScientific. Our 10 year project that is the https://t.co/AtT1kXXMXN has given rise to Via https://t.co/H1BBZ5khaf. With @mooreorless62 and @nephantes the sky is the limit. Integrating easy to manage pipelines with complex metadata will make life easier.

FINALLY!!! Single cell transcriptomics reveals dysregulated cellular and molecular networks in a fragile X syndrome model @elisadonnard @garber_manuel @GarberLab https://t.co/epOtYIa941

It is depressing that we are watching this horror unfold slowly and steadily. Clearly, it has become up to individuals to stop Exxon Valdez in the red sea. https://t.co/WSeBdxKA93 Join me in donating to the UN crowdsourcing effort https://t.co/jdHj5fXdj4

Our study on the role of T cells and interferon gamma in a mouse model of STING driven lung inflammation is now published! https://t.co/IG3ZG1Z8oM A summary of some of the interesting directions our mice have taken us: 1/8

The game changer is coming

https://t.co/kNLqQoDZli I have no idea what this is, a friend gave me this oncidium hybrid a few years back. It is bearing about 100 flowers. @OrchidTalk #Orchids

#Orchid @OrchidTalk https://t.co/eequr7apeA 5 years after I left it outside during a frost. Will Neptune's Dendrobium Kingianum alba finally bloomed. Hopefully it will be what it can be soon.

.@CocaCola: *commits to 25% reusable packaging by 2030* Also @CocaCola: *produces 13 billion more single-use plastic bottles in 2021 than previous year* Talk about #GREENWASHING😵‍💫

Nucleome Browser: An integrative and multimodal data navigation platform for 4D Nucleome https://t.co/UkczkYDZV2 #bioRxiv

Can we estimate metabolic state from single-cell transcriptomics? Led by @KHrovatin & @davidsebfischer, we review existing comp approaches for predicting single-cell metabolism, namely pathway-level analysis, constraint-based modeling & kinetic modeling. https://t.co/lH1UTKsqVK

I am still looking for postdoc to join my group. Please help me spread the word. Thanks

We propose Clipper as a general statistical framework for controlling FDR in high-throughout genomics data analysis. Clipper does not require high-resolution p-values, thus saving null distribution derivation and many rounds of permutations:

Such a clever adaptation of CUT&TAG to profile several DNA binding proteins simultaneously with adaptation to single cell profiling from Thomas Fazio and Sneha Gopalan. Happy that my group was able to help a bit.

Our paper on syntrophic microbial communities is out on @CellSystemsCP. Congrats to @MarianaNoto @BrittanyRosener and @serkansayin_. A quick recap of our findings on this🧵 https://t.co/aXF1mfFRiC

7/n However, to our surprise CCR5- were clearly found in lesions! Indicating that CCR5 function may not be recruitment but enhance Treg function. I am honored to have been able to work with such a talented group of students and my friend and colleague John.

5/n Kingsley who had just graduated and was working on CCL5 took interest in the upregulation of CCR5 in Tregs, his hypothesis was that it was critical to Treg recruitment to lesions. Consistent with this, supplementing Rag-/- with CCR5- resulted in worse disease

5/n TGFB is downregulated in lesions both in lymphocytes (TGBF1) and Melanocytes (TGFB2). It is really intriguing whether TGFB signaling is important to “hold off” disease.