Epigenetic Hulk
@epigenetichulk
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EPIGENETIC HULK SMASH PUNY GENOME. MAKE GENOME GO. LOCATION: NOT CENTROMERE, THAT FOR SURE
Joined March 2014
VERY NICE FOR THEM! FANCY OMICS CONFIRM NETWORKS! DESCRIBED 30 YEARS AGO!
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SO INTERESTING! NOW KNOW AGAIN HOW BLOOD CELL BE! FOR 15TH TIME! BUT NOW SLIGHTLY DIFFERENT! OR SAME BUT WHATEVER!.
We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Amazing teamwork with @NilUresin, @_sabrinarichter, @fabian_theis, @erwinschoof, @Bo_Porse .🧵.
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AGAIN! SINGLE CELL OF MOUSE DEVELOPMENT! REVEALS. WAIT FOR IT. WAIT FOR IT. STUFF WE KNEW BEFORE!!!!!! HURRAY BIG SUCCESS @JShendure AND COLLEAGUES AND A LOT OF MONEY TO DO WHAT EXACTLY?
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FINALLY! EPIGENETIC HULK NOW UNDERSTAND SUPERENHANCER! MAYBE! WAIT! NO. STILL CONFUSED!
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NO MORE Z AND W CHROMOSOME! ONLY ACTIVE X! SOMEONE PUT XIST ON ELON!.
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A MAMMOTH HI-C! FROM EAR! "52,000 YEARS" MENTIONED 52,000 TIME! WE GET IT! NO FREEZER BURN FOR DUMBO!
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EPIGENETIC HULK FIND OUT! NO NEED FOR HUMAN EMBRYO MODEL HULK! ALREADY IN HUMAN EMBRYO MODEL BRUCE BANNER FORM!.
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BUTT-SEQ! EPIGENETIC HULK JUST CAN'T! AND THEY SEQUENCE FLY HEAD! SO: BUTT-HEAD! NOW NEED BEAVIS (BULK EXAMINATION AT VARIABLE INTRAGENIC SITES)! @NobelPrize
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MAKING STRIPES! EVERYBODY COME TOGETHER IN MIDDLE! AT LEAST NOT PHASE SEPARATION!
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BIG NEWS! H3K4ME3 DOES STUFF AT TSS WITH POLII! BUT MAYBE NOT EXACTLY EXACTLY WHAT YOU THOUGHT! MAYBE DANCE WITH POLII A LITTLE BIT DIFFERENT! EPIGENETIC HULK NOT SEE DIFFERENCE! OR HOW DIFFERENCE IS IMPORTANT! MORE IMPORTANT THINGS IN EPIGENETIC LIFE!
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ANCIENT GENOME! NOT EPIGENOME! BUT STILL PRETTY GOOD! CONGRATULATIONS SVANTE!.
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EVERY THING OLD! NEW AGAIN! CHROMATIN REMODELERS! THEY DIFFERENT! THEY REMODEL NUCLEOSOME DIFFERENTLY! IN FLY CELL! SMASH THIS REBOOT OF 25 YEARS OF BIOCHEMISTRY AND EPIGENOMICS!! @AlexanderStark8 @lab_stark STRIKE AGAIN!
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ENHANCER! AGAIN GRAMMAR OR MOTIF OR CONTEXT! A LITTLE BIT OF EACH OBVIOUSLY! @AlexanderStark8 LAB "DISCOVER" IT AGAIN AGAIN! FORGOT SHAPE! AND TIME OF DAY! PHASE OF MOON! TEMPERATURE! HULK SMASH HARD!
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SOME ENHANCERS PLAY TOGETHER! SOME NO! OH BOY SPECIFIC ENHANCER COOPERATIVITY IS A THING AGAIN! WEIRD IS FRIEND ENHANCER STAY FARTHER AWAY FROM OTHER FRIEND ENHANCER! EPIGENOMIC COOTIES?!.
Nested epistasis enhancer networks for robust genome regulation This research between our lab, Keji Zhao (NIH), Wing Wong (Stanford), reveals an epistasis enhancer network for gene expression robustness, and predicting non-coding genome in disease risk.
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THEY UBIQUITOUS CO-FACTOR! OR NON-SPECIFIC BINDERS! THOSE EQUALLY GOOD NAMES! WHAT ARE OTHER TFS? "BLOB TFS"? "SPOT TFS"?.
Ever wonder how Transcription Factors work as a team?.Thrilled to share our latest work on TF cooperativity now online @MolecularCell .“Stripe” TFs provide accessibility to regulatory DNA in mammalian genomes.What are stripe TFs, you ask? .🧵👇. 1/13
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SYNTHETIC HOX CLUSTER! WORK LIKE HOX CLUSTER! SO REALLY BIG TRANSGENIC REPORTER! OK I GUESS BUT WE KNOW HOW HOX CLUSTER WORK! RARE REQUIRED FOR RA RESPONSE! WELL YEAH! WHAT @Duboule AND @KmitaMarie THINK!
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