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Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί Profile
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί

@drhungo

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Primary Care Physician | Educator | ASCVD, πŸ«€Failure, Diabetes | Addicted to πŸƒβ€β™‚οΈ 🏏 &πŸŒπŸΌβ€β™‚οΈ Follows Jesus, loves family, tweetsβ‰ medical advice @RACGP

New South Wales
Joined September 2015
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
5 months
The LDL Cumulative Exposure Hypothesis. The longer your arteries are exposed to high LDL-C, the ⬆️ the risk of atherosclerosis. πŸ“ˆ. πŸ”¬ Early & sustained LDL lowering = lifelong CV benefit. πŸ”— #CardioTwitter #MedTwitter #FOAMed #MedED @ACCinTouch
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
8 hours
🎀 GPCE Melbourne 2025. βœ… 6 hrs on Lipids & CV Prevention.βœ… 1 hr on Heart Failure.βœ… Dinner deep-dive: New ASCVD therapies. Don’t miss it!. πŸ‘‰πŸΌ SPEAKER50EDU to get 50% off your Session Pass. #GPCEMelbourne #MedTwitter #CardioTwitter #meded #FOAMed
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
2 days
πŸ•°οΈ Atherosclerosis isn’t random. It’s driven by:. β€’ Particle Count β†’ ApoB particles πŸ§ͺ. β€’ Permeability β†’ Endothelial dysfunction (obesity βš–οΈ, hypertension πŸ’“, diabetes 🩸, genetics 🧬 ). β€’ Passage of Time β†’ Cumulative exposure ⏳. Plaque builds silently for decades. Know
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
2 days
RT @drbennisahmed: Finerenone Reduces New-Onset Atrial Fibrillation Across the Spectrum of Cardio-Kidney-Metabolic Syndrome: The FINE-HEART….
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
4 days
β˜•οΈ Coffee O’Clock Could Shape Mortality Risk. EHJ study of >170,000 US adults finds ⏰ timing of coffee matters:. πŸ•— Morning-only coffee = ⬇️ all-cause & CVD mortality. β˜•οΈ Afternoon/evening drinkers = ☝️ higher risk. πŸ” Supports chrononutrition in CV prevention. πŸ”—
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
5 days
RT @drpablocorral: ☝️Effect of Lipid-lowering Therapies on Lp(a) Levels: A Comprehensive Meta-analysis of RCTs. ☝️New evidence just publish….
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
5 days
πŸ”₯ Atherosclerosis Starts Young: Time to Treat BP Like LDL. New EHJ editorial: life-course blood pressure matters as much as cholesterol πŸ§ πŸ«€. πŸ§’ Even modest BP elevations in youth/adulthood = ↑ plaque later in life. ⚠️ Calls for early, sustained prevention β€” not just midlife
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
6 days
πŸ§“ LDL-C Still Predicts Risk at 80+: Age β‰  Immunity. πŸ“Š Copenhagen General Study (n=91,131):. πŸ”Ί LDL-C predicts MI & ASCVD across all ages β€” incl. 80–100 y/o. πŸ’‘ NNT to prevent ASCVD over 5 yrs:.β€’ Age 80–100: 42.β€’ Age 50–59: 345. πŸ“‰ Lower LDL = lower risk, even in late life
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
7 days
🧠 Statins & Cognition: No Harm, Possible Help?. πŸ“š ASPREE & 20+ studies show:. ❌ No link between statins & cognitive decline or dementia. πŸ§“ Statin users had no faster memory loss. 🧠 Some data suggest slower decline or blunted memory loss. πŸ§ͺ RCTs ongoing: STAREE & PREVENTABLE
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
8 days
πŸ’Š Statins & T2DM: Risk Real, but Worth the Trade-Off?. πŸ“‰ JUPITER & meta-analyses confirm:. 🩺 Statins slightly ↑ new-onset T2DM (HR ~1.28) in πŸ‘₯ at risk of diabetes . βš–οΈ But benefits far outweigh risks:. βœ… 39% ↓ in major CV events. πŸ“Š NNT: 134 events prevented / 54 new T2DM
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
12 days
πŸ›£οΈ HDL’s Road Trip: How Reverse Cholesterol Transport Works. πŸ«€ RCT starts as HDL extracts cholesterol from arterial foam cells (macrophage & VSMC origins). 🚚 Cholesterol rides HDL β†’ liver via SR-B1 or transfers to VLDL/LDL via CETP. πŸ’© Ends with fecal excretion (bile or TICE
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
13 days
πŸ“Š From kids to carotids: BP history predicts midlife plaque . πŸ“ˆ BP tracked from childhood β†’ midlife predicts carotid plaque severity at follow-up (n = 2,446). πŸ§’ Elevated SBP/DBP in any decade (childhood, young adult, midlife) linked to ↑ plaque burden. πŸ’₯ Midlife BP
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
15 days
Mechanistic insights on colchicine in human plaques πŸ”¬. πŸ’Š Ex vivo human carotid plaques β†’ multiomic analysis:. βœ… ↓ Neutrophil degranulation.βœ… ↓ Platelet activation.βœ… ↓ Macrophage proliferation.βœ… ↑ ECM stabilization.❌ Minimal effect on NLRP3/IL-1Ξ². Colchicine’s ASCVD
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
19 days
Air pollution: a global driver of atherosclerosis. 🧬 Review of epidemiological & mechanistic evidence:. πŸ™οΈ PM2.5 & traffic exposure β†’ ↑ carotid IMT, coronary calcium & arterial stiffness. βš™οΈ Mechanism πŸ‘‰πŸΌ Oxidative stress, lipid oxidation, inflammation, endothelial dysfunction
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
20 days
🧬 Genetic testing in severe hypercholesterolemia isn’t just academic πŸ‘‰πŸΌ it changes lives ❀️ . In a landmark study of πŸ‘₯ with LDL-C β‰₯190 mg/dL, ~1 in 5 had an FH mutation. Carriers had CAD 22 years earlier ‼️.& ~3x risk πŸ‘‰πŸΌ despite similar LDL. πŸ’‘ Early ID = early action.
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
21 days
🚨 New data: Cardiometabolic drivers of early vascular remodeling in youth. In 522 healthy kids followed from infancy to 19y:. 🩺 BMI & insulin resistance (HOMA-IR) predict aortic IMT.🩺 BMI & systolic BP predict carotid IMT.🩺 Aortic IMT more sensitive than carotid IMT to early
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
22 days
🚨 10-year follow-up of SCOT-HEART confirms πŸ“‰β†“. 🩺 In stable chest pain:. βœ… CCTA-guided management ↓ non-fatal MI (4.3% vs 6.0%).βœ… No difference in mortality.βœ… ↑ Preventive therapies in CCTA arm.βœ… Revascularization & angiography similar. πŸ‘‰ Anatomy-driven risk.
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
25 days
🚨 Heart rate lowering (HRL): not always cardio-protective. 🩺 Meta-analysis of 157,764 πŸ‘₯ ↓HR. βœ… Benefit in post-MI & heart failure.❌ ↑Stroke & mortality in hypertension.βš–οΈ ↑ central BP πŸ‘‰πŸΌ potential harm if poorly selected. πŸ”‘ Benefits of HRL = highly context-dependent.
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
26 days
πŸ“š New study of 9,935 πŸ‘₯ with impaired renal function reveals that . ⏫️ remnant cholesterol & low-grade inflammation (hs-CRP) independently & additively ⬆️ the risk of myocardial infarction, ASCVD, mortality, and kidney events. πŸ”‘ Targeting both may reduce residual risk. ❀️
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@drhungo
Dr Rob πŸ«€πŸ©Ί πŸ‡¦πŸ‡Ί
26 days
Lp(a) & autoimmune disease = additive ASCVD risk ‼️. 🩺 353K pts (UK Biobank):. βœ… Autoimmune disease ↑ MACE risk (HR 1.30).βœ… Elevated Lp(a β‰₯125 nmol/L) ↑ MACE risk (HR 1.24).βœ… Both together: highest risk (HR 1.77).βœ… Effect consistent across multiple autoimmune conditions.
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