🧵1/ How does the brain repair myelin after injury? We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination. https://t.co/sfGHA2RH9r

Incredible work, congratulations @Oliver__Hahn

There's also a grant mechanism for international talent from @Researchirel to get significant start up funds to do top tier research in Ireland ! https://t.co/fI2Tr5l4D3

The Department of Genetics at Trinity College Dublin is hiring a new faculty member. Come join our lively, diverse and collaborative group of investigators. https://t.co/V4TMd9eqd4

Fantastic opportunity to join and amazing lab!

Fantastic new molecular technology from @Don_B_Arnold lab.

Delighted to give a talk at the wonderful @CentreMyelin annual symposium in Cambridge, UK. Truly fantastic conference and an amazing community. Thank you to @ThoraKaradottir and @mssocietyuk for organising!

Today, we are launching the first publicly available AI Scientist, via the FutureHouse Platform. Our AI Scientist agents can perform a wide variety of scientific tasks better than humans. By chaining them together, we've already started to discover new biology really fast. With

9/ None of this work would be possible without the mentorship of @stevens1lab and @macosko. Or the hard work of two phenomenal RAs: Raphael Rakosi-Schmidt and Eric Garcia! Thank you to all our collaborators and coauthors!

8/ Summary: Remyelination depends on a glial-immune axis, initiated by type I interferon signaling that summons lymphocytes. Surprisingly, these cytotoxic CD8 T-cells enhance remyelination. Full story ➡️

7/ Critically, depleting the most abundant of these lymphocytes — CD8 T-cells — led to reduced oligodendrocyte maturation, directly linking lymphocyte infiltration to successful remyelination. This was surprising, we expected CD8 T-cells to exert a negative effect on the brain

6/ What’s the function of IRG? We demonstrate that IRG secrete CXCL10, a chemokine that recruits lymphocytes into the repairing white matter. Without this glial-driven recruitment, lymphocyte infiltration was impaired.

5/ Third, we discovered a shared interferon-response program across multiple glial types. These interferon-responsive glia (IRG) clustered around remyelinating white matter — and their formation was dependent on type I interferon signaling.

4/ Second, we observed a selective infiltration of immune cells specifically during remyelination: ➡️ CD8 T-cells ➡️ Natural killer (NK) cells These lymphocytes were specifically enriched during the repair phase, not just during damage.

3/ First, glial and monocyte-derived macrophage states are highly dynamic. We found extensive transcriptional remodeling across microglia, astrocytes, and oligodendrocyte lineage cells from demyelination through to repair.

2/ We used a focal demyelination model to study the entire process of white matter injury and repair at high spatial and molecular resolution. Our goal: capture the real-time cellular and molecular dynamics driving remyelination.

Our lab website is up! We are hiring at all levels. https://t.co/F4jB52A9vU

There is still time to apply for a PhD in @LancasterUni Looking for your next step after a #neuroscience #MSc? Write to @The_shefeeq, check out his @Nature paper.. Working with a ECR, motivated to publish will make for an excellent PhD experience https://t.co/7mpf1mMtsf

2 days left to submit your abstract, register early & apply for stipend for #GLIA2025! Deadline: 5 Feb 2025, 12:00 p.m. (CET). No extensions! https://t.co/93CxRWhXrQ #gliameeting #microglia #SchwannCells #glia #Astrocytes #oligodendrocytes #stemcells

Ever wondered what memories *look* like? We visualized the 3D molecular architecture of engram synapses. 🧠 Dream collaboration between the René Frank group (@drrenefrank ) & Tomás Ryan lab (@TJRyan_77) 🙌Big ups to Charlie Lovatt🙌 Great things happen when fields collide!