Joel Boerckel
@jboerckel
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Mechanobiology of development & regeneration. Assc Prof: @PennMedicine @PennBioeng. Co-Dir: @McKayLaboratory. Dir: @Penn_PCMD Biomechanics Core. Prov. 25:2. 🦛
Philadelphia, PA
Joined April 2009
I am thrilled to release our latest preprint from @AmiLang_Science, out today @biorxivpreprint! . Local erythropoiesis directs oxygen availability in bone fracture repair. A paper thread:.
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Our problem is not that our society does not sufficiently appreciate the economic return on investment in science. It is that we value education and knowledge generation only in economic terms.
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RT @DrWoappi: it is my distinguished honor to be this year's Spring Commencement Speaker at @PittBradford!.
pittwire.pitt.edu
The Columbia University professor researching wound healing and regeneration will also receive an Alumni Award of Distinction.
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An public service announcement:. Sinclair Lewis’s “It Can’t Happen Here” is in the public domain.
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Huge congrats Dr. @StphanePetrousk!!. And many thanks @HoeyLab for the fantastic visit!.
🎉 Huge congratulations to the latest Doctor in the house, @StphanePetrousk , who successfully defended his PhD thesis this morning! 🥳 Big thank you to his committee, Mark Ahearne @drmgmonaghan, and to his external examiner @jboerckel for a great discussion and excellent seminar
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Tomorrow is @madhura0327’s Ph.D. thesis defense!. I’m so proud of everything she’s accomplished. If at Penn, hope you can make it. If you’d like a zoom link, just reach out to Madhura. “The Role of YAP in Bone Fracture Repair”.3.00 PM, Reunion Auditorium John Morgan Building.
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Returning home rejuvenated by time w so many dear friends at #ORS2025. Also so proud and thankful for my group. Special congrats to @cpane94 on winning the NIRA, @AmiLang_Science on @isfrfractures🥇Podium Award and @ESeidlScience on @ors_tendon 3MT Award 🙌
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RT @cpane94: Wonder how maternal movements impact fetal skeletal development? Join my #ORS2025 NIRA talk! @isfrfractures @orssociety @jboer….
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Excited for #ORS2025 and super proud of this group who will be presenting their work!. 🙌🏻 @Madhura0327 @GeorgeKotsaris @ESeidlScience @AmiLang_Science @cpane94 . ht @cpane94 for the slide!
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RT @cpane94: Excited to debut my vision for the Panebianco Lab™️ at #ORS2025 ! @ORSsociety #OrthoTwitter #FuturePI.
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RT @AmiLang_Science: So proud of our latest work 😍🦴🩸 This project was a rollercoaster 🎢, but I loved every moment of it. Huge thanks to all….
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So wonderful to have @JoyYWu as @Penn_PCMD Visting Professor! Thanks for the great talk, Joy!
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So, next time you’re doing algebra, I hope it reminds you of the remarkable process of bone fracture repair. This has been the most surprising and exhilarating ride. We would love feedback as we send this paper for peer review:.
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Together, these data upend our current understanding of the early phase of bone fracture repair, provide a mechanism for high oxygen tension in the bone marrow after injury, and reveal an unexpected and targetable role of erythroid progenitors in fracture repair.
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Remarkably, making the fracture site hypoxic promoted angiogenesis and increased bone formation.
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Annemarie then did a cool experiment: she treated fractures with a CD71-blocking antibody, which prevents iron import. CD71 blockade arrested heme synthesis and made the fracture site hypoxic!
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These erythroid progenitor cells express CD71, or Transferrin receptor 1. Erythroid cells are super iron-hungry, as they begin to make hemoglobin, which uses iron to bind oxygen. Transferrin receptor is the primary iron transporter in these cells.
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We found that fracture activated local erythroid progenitor cells, without a change in serum EPO!
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Now, when a bone is fractured, it breaks the bone and ruptures the vessels, but it also breaks the bone marrow. Bone marrow is special because it is the site of erythropoiesis: the production of new red blood cells from stem cells.
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What could cause this high oxygen? Fracture rapidly causes hematoma formation, which arrests bleeding and cuts off the supply of new erythrocytes. So, we took a single cell approach to identify the cell populations at the fracture site, compared to contralateral bone marrow.
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We measured bone marrow at ~30mmHg as expected, but the oxygen at the early fracture site was almost 60 mmHg - higher in oxygen than the spleen, which is rich in oxygenated red blood cells.
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