Deepak Kumar
@deepakdbg90
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Research scholar at TAU, Israel, exploring the role of #CRISPR in microbial evolution, #Antifungal resistance, #Ph.D. student, #Maithil
Joined August 2013
New insights about antiviral immunity!. We show that a TIR–SAVED effector from a Type II #CBASS system can function independently of its cyclase, by sensing a host-conserved signal, previously linked to osmotic stress. Upon sensing this signal, the effector depletes NAD⁺ and.
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RT @VinnieViruses: Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mech….
nature.com
Nature - N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal...
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RT @JessicaSacher: 🧬 CRISPR experiments just got an AI co-pilot!. @lecong's group at @Stanford has developed CRISPR-GPT — an LLM agent syst….
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RT @kvnforsberg: My lab’s first preprint!. We used functional metagenomics to identify phage defenses in human and soil microbiomes. We sca….
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RT @NobregaFL: Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication an….
cell.com
Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses phage attachment at the membrane and assembles a transmembrane complex that halts infection by blocking phage DNA...
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RT @AframianNitzan: 1. Interested in general principles and constraints of anti-phage defense? .Happy to share a new preprint where we desc….
biorxiv.org
The evolutionary arms race between bacteria and their phage viruses has given rise to elaborate anti-phage defense mechanisms. Major advances have been made in revealing the molecular details...
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RT @DebnathGhosal: 📣 New paper alert! One of the most exciting projects we've done in recent years is now out on BioRxiv: "An Asgard archae….
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RT @SternbergLab: 1/16 New pre-print from the Sternberg Lab!.We uncover how temperate phages can use RNA-guided transcription factors to re….
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RT @biorxiv_micrbio: A Phage Ejectosome Protein Moonlights to Inhibit CBASS Anti-Viral Defense System #biorxiv_micr….
biorxiv.org
A family of prokaryotic antiviral systems collectively known as the cyclic oligonucleotide-based signaling system (CBASS) is found in many bacterial species. Phage defense in CBASS is mediated by the...
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RT @NatureMicrobiol: Out Now! Structure of an archaeal ribosome reveals a divergent active site and hibernation factor .
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RT @pacyc1841: Prophages block cell surface receptors to preserve their viral progeny | Nature
nature.com
Nature - Zip promotes the accumulation of free phages in bacterial lysogen communities, safeguarding phage progeny.
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RT @cellhostmicrobe: Phage counter-defense repertoires:.New work IDs broad & specific anti-defense genes in variable regions of Pseudomonas….
cell.com
Costa, van den Berg, Esser, et al. identify two broad and three specific anti-defense genes by examining variable regions of Pseudomonas phage genomes. These inhibitors neutralize diverse bacterial...
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RT @protasov_evgeni: Archaeal virus entry and egress.Archaea also have viruses and they are cool! .#microbiology #virology #virus #viruses….
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RT @HsiehYp: Exciting news! I am launching the Lab of Polymicrobial Interaction & Evolution @IPMBSinica @AcadSinica! 🎉 Our brand-new websit….
labofpie.org
We study the mechanisms of cross-kingdom microbial competition and how it influences microbial evolution and interaction with hosts
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RT @crypticprophage: New type IX toxin/antitoxin system, anti-phage system Clover, where antitoxin produces 5′-trip….
biorxiv.org
The cellular nucleotide pool is a major focal point of the host immune response to viral infection. Immune effector proteins that disrupt the nucleotide pool allow animal and bacterial cells to...
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RT @pacyc1841: Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution.
biorxiv.org
Horizontal gene transfer plays a key role in bacterial evolution, yet its efficiency under natural conditions, especially between genetically distinct strains, remains unclear. Using Staphylococcus...
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RT @biorxiv_micrbio: Identifying phage proteins that activate the bacterial innate immune system #biorxiv_micrbio.
biorxiv.org
Bacteria have evolved sophisticated antiphage systems that halt phage replication upon detecting specific phage triggers. Identifying phage triggers is crucial to our understanding of immune signal...
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RT @biorxiv_micrbio: Histone diversity in the archaeal domain of life #biorxiv_micrbio.
biorxiv.org
Archaea represent a distinct domain of life that is genetically and biochemically unique from bacteria and eukaryotes. Two-thirds of all archaea encode histones, proteins that are ubiquitously used...
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