debaditya_roy
@debaditya_roy
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~Consultant Rheumatologist~ MD Medicine,DM Rheumatology, SCE Rheumatology(RCP UK) EULAR European Certificate in Rheumatology, Ex-SR Rheumatology,AIIMS New Delhi
Kolkata , India
Joined July 2013
🌟🌍A humble effort towards sharing global perspective on RA remission. Thanks to @chroniceileen! 💫 🔗Find the link to this talk below : https://t.co/SuIok5FgKP
#TalkOverRA Campaign #RA #RheumatoidArthritis
@ACRheum @IndianRheum @Amansharmapgi @12VRavindran @PanktiMehta24
#Ad in partnership with AbbVie for the #TalkOverRA Campaign but all content created is my own opinion and views or those who I have interviewed! I'm so excited to share with you three more pieces of content I have created for the Talk Over RA campaign. I most certainly learned a
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🧩 Take part in the Digital Rheumatology Radar Survey —an international research project by @DigitalRheumatology @JK77775 🌟Lets explore how we are adopting & implementing digital innovations in rheumatology—from telemedicine to clinical decisions & AI-enhanced learning! 🌍 👇🏻
Digital Rheumatology Radar Survey - An international research project by the @DigitalRheumatology
@JK77775 See how your country performs compared to others in adopting and implementing digital tools in rheumatology practice! https://t.co/cj8lJuqbUP
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🥁🥁🥁And the winner is...CAR-Titans from India!🇮🇳 Huge round of applause to Team members : 🌟🌟Dr.Mohith,Dr.Ritesh , ably led by Dr.Sarath !🌟🌟 🪄💫Congratulations on winning the #ACR Knowledge Bowl at ACR Convergence 2025! 🏆🎉 🇮🇳🌍 #ACR25 #ACRambassador
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5️⃣🏆 Pro Tips — Imaging Like a Pro! Ultrasound: Zero radiation, instant answers, but operator’s luck may vary CT Angio: Top for odd shapes, not for subtle stuff MR Angio: Loves inflammation, dislikes rush jobs FDG PETCT: Finds trouble early, but check your wallet
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4️⃣Slide 5: 📅 When to Use What? GCA? Start with Ultrasound; add CT/MR if arteries play hide and seek. Takayasu? Heavy artillery like CT/MR shines. F DG PETCT: Call only for mysterious cases or plot twists.
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3️⃣ 🔍 Modalities: The Cast List 🔍Ultrasound: Quick selfie, best for shallow arteries 📸CT Angio: Crystal clear, but beware of drama (radiation!) ⚡MR Angio: No radiation, but needs a high-tech crew 🧑🔬FDG PETCT: Catch inflammation before it’s cool, but expensive
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2️⃣🌟Imaging sorts the plot: Diagnoses, maps disease territory, tracks activity, and spots surprises
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#ACR25 #ACRambassador 🧵Imaging in #LVV 1️⃣ 🚨 What’s LVV? 🚨Big arteries throwing tantrums — meet Large Vessel Vasculitis! Main villains: #Giant Cell Arteritis & #Takayasu #Arteritis, targeting the aorta and its major friends. 🕵♀️🕵♂️ Imaging = Detective work 👀
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6️⃣ When AI Meets Drug Discovery 🚀 Generative AI discovered a TNIK inhibitor (now in Phase 2a trial) for pulmonary fibrosis. AI-guided multi-omics modeling now unveils disease networks in ME/CFS and beyond.
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5️⃣ When Microbes Rewrite Immunity Chronic infections and dysbiotic gut species break tolerance, triggering autoimmunity. Enterococcus gallinarum translocation and tryptophan-derived metabolites link microbiome signals to Th17 activation and autoimmunity.
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4️⃣ Autoantibodies — Enemies & Allies Lupus-derived antibodies enter live cells via ENT2 transporters and can deliver RNA or drugs inside tumors. This discovery fuels ANA-drug conjugates (ANADCs) as innovative cancer therapies.
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3️⃣ Predicting Rheumatoid Arthritis Before It Begins “At-risk” ACPA+ individuals already show effector T cell activation and evolving epigenetic changes. TFH and monocyte signatures predict clinical conversion; abatacept reverses these, unlike TNFi.
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2️⃣ RNA-modified Immunology & Smarter mRNA Delivery RNA N-glycosylation conceals danger signals, helping immune evasion. In vivo CAR-T mRNA therapy now manufacturable directly within the body using lipid nanoparticles — a leap for immune therapy precision.
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1️⃣ Decoding Innate Immunity & Genetic Resilience The “HAQ-STING” variant protects against severe inflammation in COPA syndrome by blocking excess interferon signaling. Opens doors for gene-edited or therapeutic STING modulation in interferonopathies.
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🧵 Thread: The 2025 Breakthroughs in Basic Science (ACR Convergence)🌎 ⭐️⭐️From gene editing to AI in drug discovery — check out these 6 core updates reshaping rheumatology and translational medicine this year!!👇 #ACR25 #ACRambassador
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7️⃣ Take-home truth: axSpA isn’t just about bones fusing — it’s about recognizing the pattern before the damage is done. Radiographs, MRI, and clinical clues must dance in sync. 📸 “The earlier we see, the better we treat.” 🩻 #ACR25 #RheumTwitter #ACRambassador
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6️⃣ The checklist cure for confusion: ✅ Symmetric SIJ changes → SpA ✅ Erosions/pseudo-widening → SpA ✅ Bulky osteophytes → degenerative/DISH ✅ Iliac sclerosis → could be SpA or OCI Add HLA-B27 + inflammatory story = diagnosis with confidence.
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5️⃣ Don’t fall for the mimics! Not every bright sacrum is SpA. 🚫 Mechanical stress = anterior, asymmetric, older patients 🚫 Osteitis condensans ilii = triangular sclerosis in women 🚫 DISH = flowing “candle wax” ossification Even radiology has imposters.
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4️⃣ The MRI magic: When STIR lights up the SI joint, that’s active inflammation talking. 🔹 Bright = BME 🔹 Plus synovitis, enthesitis, erosions, fat metaplasia 🎯 If you see “backfill,” think chronicity, not activity.
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