🚨 New paper in @jclinicalinvest! Kidney lymphatics are a promising target in transplant rejection 🗺️ In rejection, lymphatics expand and adversely remodel ⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system https://t.co/Hki81lmvLp 1/4

We're thrilled to announce SeqHub, an AI-enabled platform for biological sequence analysis. SeqHub brings together sequence search, genome annotation, and data sharing in one place. I dreamed of a single place where I could learn everything about my sequences. Today, a much more

Thank you, @NatureBiotech, for highlighting our work and the potential clinical promise of microRNA therapeutics for ADPKD and other common conditions. @Novartis is leading the clinical development of the ADPKD therapeutic (Farabursen) https://t.co/nDzhJkbTxZ

🚨 New Resource Alert! From @uniklinik_aachen & @novonordisk — we present an Integrated Single-Nucleus Atlas for Human Heart Failure 🫀 A comprehensive map built from 1.8M nuclei across 195 patients. Preprint: https://t.co/atsBEVhxI2 🧵Here’s what’s inside:

Transient tissue residency and lymphatic egress define human CD56bright NK cell homeostasis @NatImmunol @bjorkstrom_lab @BettsLab @karolinskainst @Penn https://t.co/1nHvyIpmRB🇸🇪🇺🇸 Congrats on another great story, Annika and Niklas!

Congratulations to our prize winners from Driving Discoveries🎉 This year we had two winners for the best oral presentation prize. Dr @daniyal_jafree, from UCL, for his work looking at how lymphatic vessels in kidney transplants change when the transplant is rejected by the

Join our PKD team Apply now! https://t.co/Lxge8WefDM

Our new report, looking into rare kidney diseases in the UK, has uncovered shocking statistics in diagnosis delays, inconsistent care, and long waits for new treatments, with the impact being more severe for children. Rare kidney diseases include over 150 distinct diseases

🔬Important PKD Research News! Researchers at University College London (UCL) have found that tiny kidney blood vessels are damaged early in polycystic kidney disease (PKD) — even before kidney function declines. This discovery could lead to earlier diagnosis and new treatment

Sharing this excellent review now out from postdoc Sarah McLarnon! Lots of useful info on 3D imaging, quantification of imaging data, and how this has been applied to the kidney. #FluorescenceFriday figure with our own imaging data! https://t.co/FH6wTlq8l0

JCI - Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection

🚨 Kidney + AI milestone 🚨 Never been more excited to share!!! We built Nephrobase Cell+, the first multispecies, multimodal kidney foundation model: Trained on ~40M cells Across 4 species (human, mouse, rat, pig) From 5 modalities (scRNA, snRNA, snATAC, CosMx, Xenium) Kidney

Happy to share the results and data of Human Kidney Atlas V2 covering over 350 patients, resulting from a team effort by KPMP and HuBMAP.

Very excited to share our latest preprint – We find that childhood brain tumours instruct cranial haematopoiesis allowing immunotolerance of childhood brain tumours and CNS development. A thread 1/11 https://t.co/UYAqszigN8 @Gilbertson_Lab @CRUK_CI @LPTrustUK @BrainTumourOrg

This #OrganDonationWeek, we are proud to share QUOD’s role in a study by Menna Clatworthy’s group @Cambridge_Uni. The study used kidney samples provided by QUOD to assess the biological organ age of kidneys prior to transplantation. Find out more here:

Just out in @Nature_NPJ Imaging - our team used the world’s brightest X-ray to map the vasculature in an intact human kidney down to the tiny arterioles 🫘 🌍 Amazing work by the @hip_ct team across @UCLMechEng, @esrfsynchrotron & @UCL_ICH_Kidney Paper: https://t.co/643Ytd7n6A

Check out our latest manuscript where we generate a cross model single cell and spatial atlas of mouse PKD! A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease | bioRxiv

Delighted to play a small part in this huge effort from the @Zimmermk1986 lab They built a census of scRNAseq datasets of mouse models of PKD 🐭 🫘 And best of all, they made a user-friendly web atlas to accelerate discovery for the PKD community 👇 https://t.co/rxlffTG0xD

Take a peek: This issue’s cover features 3D imaging and single-cell genomics by David A. Long, @daniyal_jafree & team @ucl, revealing lymphatic rewiring in #kidney tissue with chronic #transplant rejection: https://t.co/JpvYX4IiKA The cover image shows 3D reconstruction of a

Our newest human kidney assembloid model features the formation of spatially-patterned human nephrons connected to a central collecting system. It exhibits a variety of kidney functions in vitro and in vivo. Online now in Cell Stem Cell: https://t.co/pOojmHNUnh

New research results on kidney transplant rejection 🎉 Dr Daniyal Jafree and Professor David Long, with their research teams, have been looking at the role of the lymphatic system in kidney transplantation to see if it is good or bad. Using a powerful 3D imaging technique to