Jianhan (Johnson) Zhou
@chou15_johnson
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somewhere between home, the box, or my hood @HarvardCCB RLiu Lab
Joined December 2022
đ¨My first solo paper out in @J_A_C_S! đ¨ We deleted sulfur from a range of S-heterocycles (C, Si, O, N) using Ni catalysis. đ§ Avoids catalyst deactivation! đ Offers a unique retrosynthetic disconnection! https://t.co/MQf67RjKsw
@HarvardCCB @RichrdLiu #JACS
pubs.acs.org
The construction of CâC bonds by contractive âdeletionâ of the sulfur atom from a CâSâC motif is a useful transformation for the synthesis of complex heterocycles. The transformation allows a user to...
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Our latest cobalt catalysis paper is out now in JACS ASAP! See Mingxin and Vibhaâs work on asymmetric E/Z alkene synthesis below 𧪠https://t.co/7RUrsnTYgw
pubs.acs.org
Catalytic asymmetric reactions are primarily used to install new stereogenic centers highly enriched in either the R or the S configuration. Here, we demonstrate that chiral catalysts can also be...
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Application of Asymmetric Catalysis in the E/Z-Stereodivergent Synthesis of Alkenes | Journal of the American Chemical Society
pubs.acs.org
Catalytic asymmetric reactions are primarily used to install new stereogenic centers highly enriched in either the R or the S configuration. Here, we demonstrate that chiral catalysts can also be...
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Pd-cat. azidation of ArâBr and âOTf using NaNâ efficiently forms aryl azides. Bulky phosphine ligands enable catalysis by promoting reductive elimination and preventing catalyst deactivationď˝Pd-Catalyzed Azidation of Aryl (Pseudo)Halides https://t.co/0nQ27yze82
pubs.acs.org
Organic azides are powerful tools in organic synthesis, chemical biology, and drug discovery. Pd catalysts have become general tools for CâN bond formation from aryl electrophiles, but azide stands...
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Mechanism of Redox-Neutral Radical Cross Coupling (another fun collaboration with the Blackmond Group), out today in @ChemRxiv : https://t.co/OD6HK6HTiY
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Final version out today in @Nature : https://t.co/eOALiKCxRL Thanks to the Roberto and Cravatt labs for biological evaluations!
SAXITOXIN simplified: Appearing today in @ChemRxiv is a short, highly scalable, convergent approach to this entire natural product family using a tactical combination of radical retrosynthesis, biocatalysis (in collaboration with Merck), and CâH functionalization logic:
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In our total synthesis of psathyrin A fresh @J_A_C_S, we challenged the MHAT radical chemistry to build four-membered ring and it worked! Total Synthesis of (â)-Psathyrin A Enabled by Radical Cyclization | Journal of the American Chemical Society
pubs.acs.org
We report herein an enantioselective total synthesis of (â)-psathyrin A, an antibacterial diterpene natural product possessing a unique 6/4/5/5 tetracyclic carbon skeleton and seven contiguous...
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Arylboration of Cyclic Enones via Cooperative Copper/Palladium Catalysis (@JOC_OL): https://t.co/wZr8joDnTn.
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Adding to the growing toolbox of aryl azide syntheses: From @Shangyu_Li on @ChemRxiv, Pd-catalyzed coupling of ArBr/ArOTf with NaN3. This reaction is trickier than it looks: as we show, [LPd-N3]2 dimers form with many L's & the pdt can inhibit Pd(0). https://t.co/w8Req4nD39
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#TotalSynthesis of (â)-Neocucurbol C Enabled by Pattern Recognition and MHAT Cyclization by Li-Ping Zhong, Cyrus Gudeman, Jingsong Zhen (@jzhe265), Oshani A. Wanasinghe, Jacob Hellmig, Michael J. E. Collins, John Bacsa, Alexander Adibekian, @MingjiDai at @EmoryChem in @J_A_C_S
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Our neocucurbol C total synthesis is out @J_A_C_S! Total Synthesis of (â)-Neocucurbol C Enabled by Pattern Recognition and MHAT Cyclization | Journal of the American Chemical Society
pubs.acs.org
We report an asymmetric total synthesis of (â)-neocucurbol C, a diterpene natural product possessing a unique and complex 6/6/5/5/6 polycyclic skeleton and nine stereocenters. Pattern-recognition...
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Clever use of Ramberg-Backlund!
Base-Mediated Alkylation of Pyrimidines via Sulfur Deletion | Organic Letters
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Remote-Markovnikov Hydrobromination and Hydrochlorination of Allyl Carboxylates via Dual Photoredox/Cobalt Catalysis https://t.co/XGYFZ6jSrj
pubs.acs.org
Alkyl halides are ubiquitous motifs in pharmaceuticals, agrochemicals, and materials, yet direct access to regioisomeric variants remains limited. Conventional hydrohalogenation of alkenes proceeds...
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Direct NâSF5 and NâSF4CF3 Bond Formation through Strain-Release Functionalization of 3-Substituted [1.1.0]Azabicyclobutanes | Journal of the American Chemical Society @CRP_Laboratory @ucdavis
pubs.acs.org
In comparison to modern methods for carbonâSF5 bond formation, methods for direct heteroatomâSF5 bond formation are exceptionally scarce, rendering motifs such as âNâSF5â virtually unexplored in the...
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My labâs next paper is out in JACS! Our electrode-orthogonal self-assembled layers can "self-heal" after degradation -- the key is a dynamic linkage we can molecularly tune! Hats off to Nico! https://t.co/KF8XTQaEwa
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From Alex in the @ChirikGroup . Site-selective Co-catalyzed borylation of electron-rich arenes, now out in @J_A_C_S.
pubs.acs.org
A method for promoting highly active and site-selective cobalt-catalyzed C(sp2)âH arene borylation is described. Addition of tert-butyl ethylene (TBE) increased the activity of the cobalt-catalyzed...
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Ni-Catalyzed Reductive Ring Contraction via Desulfurative Cross-Coupling | Journal of the American Chemical Society @TotalSyntheses @Harvard @HarvardCCB
pubs.acs.org
The construction of CâC bonds by contractive âdeletionâ of the sulfur atom from a CâSâC motif is a useful transformation for the synthesis of complex heterocycles. The transformation allows a user to...
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https://t.co/vRcAE8GtYB Photoinduced Thia-Baeyer Villiger oxidation. Found this gem while doing some lit searches.
nature.com
Nature Communications - The development of thia-Baeyer-Villiger reactions has been elusive so far due to competitive oxidation of sulfoxides to sulfones. Here, the authors show a...
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