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Jianhan (Johnson) Zhou Profile
Jianhan (Johnson) Zhou

@chou15_johnson

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somewhere between home, the box, or my hood @HarvardCCB RLiu Lab

Joined December 2022
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@chou15_johnson
Jianhan (Johnson) Zhou
@chou15_johnson
2 months
🚨My first solo paper out in @J_A_C_S! 🚨 We deleted sulfur from a range of S-heterocycles (C, Si, O, N) using Ni catalysis. 🔧 Avoids catalyst deactivation! 🔁 Offers a unique retrosynthetic disconnection! https://t.co/MQf67RjKsw @HarvardCCB @RichrdLiu #JACS
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pubs.acs.org
The construction of C–C bonds by contractive “deletion” of the sulfur atom from a C–S–C motif is a useful transformation for the synthesis of complex heterocycles. The transformation allows a user to...
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@BaranLabReads
Baran Lab
@BaranLabReads
18 days
Final version out today in @Nature : https://t.co/eOALiKCxRL Thanks to the Roberto and Cravatt labs for biological evaluations!
@BaranLabReads
Baran Lab
@BaranLabReads
7 months
SAXITOXIN simplified: Appearing today in @ChemRxiv is a short, highly scalable, convergent approach to this entire natural product family using a tactical combination of radical retrosynthesis, biocatalysis (in collaboration with Merck), and C–H functionalization logic:
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@MingjiDai
Mingji Dai
@MingjiDai
19 days
In our total synthesis of psathyrin A fresh @J_A_C_S, we challenged the MHAT radical chemistry to build four-membered ring and it worked! Total Synthesis of (−)-Psathyrin A Enabled by Radical Cyclization | Journal of the American Chemical Society
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pubs.acs.org
We report herein an enantioselective total synthesis of (−)-psathyrin A, an antibacterial diterpene natural product possessing a unique 6/4/5/5 tetracyclic carbon skeleton and seven contiguous...
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@Boron_Chemistry
Boron-Chem-Research
@Boron_Chemistry
22 days
Arylboration of Cyclic Enones via Cooperative Copper/Palladium Catalysis (@JOC_OL): https://t.co/wZr8joDnTn.
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@RichrdLiu
Richard Liu
@RichrdLiu
1 month
Adding to the growing toolbox of aryl azide syntheses: From @Shangyu_Li on @ChemRxiv, Pd-catalyzed coupling of ArBr/ArOTf with NaN3. This reaction is trickier than it looks: as we show, [LPd-N3]2 dimers form with many L's & the pdt can inhibit Pd(0). https://t.co/w8Req4nD39
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@TotalSynthesis
Total Synthesis
@TotalSynthesis
1 month
#TotalSynthesis of (−)-Neocucurbol C Enabled by Pattern Recognition and MHAT Cyclization by Li-Ping Zhong, Cyrus Gudeman, Jingsong Zhen (@jzhe265), Oshani A. Wanasinghe, Jacob Hellmig, Michael J. E. Collins, John Bacsa, Alexander Adibekian, @MingjiDai at @EmoryChem in @J_A_C_S
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@MingjiDai
Mingji Dai
@MingjiDai
1 month
Our neocucurbol C total synthesis is out @J_A_C_S! Total Synthesis of (−)-Neocucurbol C Enabled by Pattern Recognition and MHAT Cyclization | Journal of the American Chemical Society
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pubs.acs.org
We report an asymmetric total synthesis of (−)-neocucurbol C, a diterpene natural product possessing a unique and complex 6/6/5/5/6 polycyclic skeleton and nine stereocenters. Pattern-recognition...
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@chou15_johnson
Jianhan (Johnson) Zhou
@chou15_johnson
1 month
Clever use of Ramberg-Backlund!
@jacsoljoc
Jacsol Joc
@jacsoljoc
1 month
Base-Mediated Alkylation of Pyrimidines via Sulfur Deletion | Organic Letters
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@chou15_johnson
Jianhan (Johnson) Zhou
@chou15_johnson
2 months
Remote-Markovnikov Hydrobromination and Hydrochlorination of Allyl Carboxylates via Dual Photoredox/Cobalt Catalysis https://t.co/XGYFZ6jSrj
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pubs.acs.org
Alkyl halides are ubiquitous motifs in pharmaceuticals, agrochemicals, and materials, yet direct access to regioisomeric variants remains limited. Conventional hydrohalogenation of alkenes proceeds...
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@J_A_C_S
J. Am. Chem. Soc.
@J_A_C_S
2 months
Direct N–SF5 and N–SF4CF3 Bond Formation through Strain-Release Functionalization of 3-Substituted [1.1.0]Azabicyclobutanes | Journal of the American Chemical Society @CRP_Laboratory @ucdavis
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pubs.acs.org
In comparison to modern methods for carbon–SF5 bond formation, methods for direct heteroatom–SF5 bond formation are exceptionally scarce, rendering motifs such as “N–SF5” virtually unexplored in the...
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@anna_wuttig
Anna Wuttig
@anna_wuttig
2 months
My lab’s next paper is out in JACS! Our electrode-orthogonal self-assembled layers can "self-heal" after degradation -- the key is a dynamic linkage we can molecularly tune! Hats off to Nico! https://t.co/KF8XTQaEwa
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@pchirik
Paul Chirik
@pchirik
2 months
From Alex in the @ChirikGroup . Site-selective Co-catalyzed borylation of electron-rich arenes, now out in @J_A_C_S.
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pubs.acs.org
A method for promoting highly active and site-selective cobalt-catalyzed C(sp2)–H arene borylation is described. Addition of tert-butyl ethylene (TBE) increased the activity of the cobalt-catalyzed...
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@J_A_C_S
J. Am. Chem. Soc.
@J_A_C_S
2 months
Ni-Catalyzed Reductive Ring Contraction via Desulfurative Cross-Coupling | Journal of the American Chemical Society @TotalSyntheses @Harvard @HarvardCCB
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pubs.acs.org
The construction of C–C bonds by contractive “deletion” of the sulfur atom from a C–S–C motif is a useful transformation for the synthesis of complex heterocycles. The transformation allows a user to...
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@chou15_johnson
Jianhan (Johnson) Zhou
@chou15_johnson
4 months
https://t.co/vRcAE8GtYB Photoinduced Thia-Baeyer Villiger oxidation. Found this gem while doing some lit searches.
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nature.com
Nature Communications - The development of thia-Baeyer-Villiger reactions has been elusive so far due to competitive oxidation of sulfoxides to sulfones. Here, the authors show a...
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@J_A_C_S
J. Am. Chem. Soc.
@J_A_C_S
4 months
A Catalytic Asymmetric Intramolecular [4 + 1]-Cycloaddition for the Total Synthesis of Terpene Alkaloid Natural Products | Journal of the American Chemical Society @UyedaLab @Research_Purdue @TotalSyntheses
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pubs.acs.org
Intramolecular Diels–Alder reactions are privileged strategic disconnections in the synthesis of polycyclic natural products containing six-membered rings. The analogous [4 + 1]-cycloaddition may...
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@MingjiDai
Mingji Dai
@MingjiDai
4 months
Check out our illisimonin A total synthesis @J_A_C_S and find out how we make an olefin dance around the ring! Total Synthesis of (−)-Illisimonin A Enabled by Pattern Recognition and Olefin Transposition | Journal of the American Chemical Society
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pubs.acs.org
We report an asymmetric total synthesis of (−)-illisimonin A, a sesquiterpene natural product with neurotrophic activity. Illisimonin A possesses a unique cage-like 5/5/5/5/5 pentacyclic scaffold...
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@TotalSynthesis
Total Synthesis
@TotalSynthesis
4 months
#TotalSynthesis of (−)-Illisimonin A Enabled by Pattern Recognition and Olefin Transposition by Bo Xu, Ziyao Zhang, and @MingjiDai at @EmoryChem in @J_A_C_S https://t.co/HjQwzpeU2F
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@J_A_C_S
J. Am. Chem. Soc.
@J_A_C_S
5 months
Light- and Heat-Responsive Frustrated Lewis Pair Enables On-Demand Fixation of Ethylene | Journal of the American Chemical Society @osaka_univ_e @osaka_univ
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pubs.acs.org
Frustrated Lewis pairs (FLPs) have been widely utilized as useful reagents and catalysts for activation of small molecules (SMs) through thermally controlled equilibrium formation of FLP–SM adducts....
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