Recently, I had the privilege of competing in the 3 Minute Thesis competition at Yale. Truly honored & humbled by all the support, and thank you again to everyone who came out! If by any chance you want to hear me talk about my favorite virus, please check out the link below. 💜

Honored beyond words to receive the 2023 @LEOFondet award for region Americas - this will be a huge boost to our groups efforts to help patients suffering from inflammatory granulomatous disorders. Congrats to the other winners @LMackayLab @drpaternoster !!

Excited to see my postdoctoral work published @ScienceMagazine! We know that certain commensal bacteria stimulate T cells upon colonization. We wondered, what are these T cells capable of? 1/5

Congratulations to Dr. Strine ⁦@madisonstrine⁩ on her outstanding thesis defense today! We couldn’t be more proud! ⁦@YaleIBIO⁩ ⁦@Yale_LabMed⁩

So grateful and overjoyed that @ScienceChow and I will be continuing our physician-scientist training at @PennMedicine! Thank you so much to all our mentors at @YaleMed @YaleMDPhD @YaleIBIO @YaleGenetics @yalederm @YaleCancer for their support! #Match2023

Excited (and a bit nervous) to share my first study as senior author! @ericsongg and I took a deep dive into whether IFNg signaling gene mutations indeed confer resistance to immune checkpoint blockade (ICB). Letter in @Cancer_Cell:

Excited to share our paper out today in @NatureGenet identifying the mSWI/SNF chromatin remodeling complex as a host-directed drug target for SARS-CoV-2 infection. Great collaboration with @CKadoch @kadochlab. Led by @JinWei0911 & @ajinkyapatil00

Big thanks to my amazing mentor & dermatologist-scientist role model @billdamsky as well as wonderful @yalederm collaborators Michael Murphy, @KatieRSingh, @alicew0624, @ScienceChow, Sarah Kim, Dr. Jeffrey Cohen, and @ChristineJKoMD! (end)

Ultimately, we are excited about how cytokine profiling can provide further biological insight into inflammatory skin diseases and help inform the selection of targeted therapies for our patients! (8/n)

Our findings therefore suggest a unique immunology of psoriasis and eczema on acral sites – this may underlie the often-overlapping morphologic features seen in these conditions as well as their incomplete response to biologics that target a single cytokine pathway. (7/n)

However, we were surprised to find that IFNG and IL13 were both expressed in PP as well as HPE. This contrasted with the divergent expression of these cytokines in non-acral psoriasis (IFNG predominant, no/low IL13) and non-acral eczema (IL13 predominant, no/low IFNG). (6/n)

We found that IL17A mRNA staining distinguished PP from HPE, similar to how IL17A expression distinguishes non-acral psoriasis from non-acral eczema. (5/n)

We evaluated expression of IL17A, IFNG, and IL13 in acral biopsies using RNA in situ hybridization (RISH). Our lab previously showed that RISH for these cytokines effectively distinguishes psoriasis (IL17A+IFNG) from eczema (IL13) on non-acral skin: https://t.co/DoYKehSgZ5 (4/n)

Example pics of HPE (left) and PP (right) from https://t.co/VBLXqE4Va7 (3/n)

Our goal was to determine whether cytokine biomarkers could augment diagnosis of acral dermatoses such as hyperkeratotic palmoplantar eczema (HPE) and palmoplantar psoriasis (PP), which can at times be difficult to classify clinically and histopathologically. (2/n)

So excited to share our work mentored by @billdamsky in @jidinnovations using cytokine biomarkers to distinguish psoriasis and eczema on acral skin! https://t.co/WV8GiTUoih (1/n)

Congrats @tianyangmao and @BenIsraelow!

Awesome work by @ScienceChow and @ericsongg!!

My first podcast! A bit nerve wracking but a lot of fun

Honored to have the opportunity to present our work using cytokine RNA in situ hybridization to characterize acral dermatoses at #ASDP22! Thank you @billdamsky for all his mentorship on this project!