An integrative characterisation of proline cis and trans conformers in a disordered peptide https://t.co/sNXLXxrIjg #biorxiv_biophys

Protein fractals are a thing! BUT their beguiling looks can be deceiving - these have the hallmarks of being accidentally (and neutrally) evolved... Such interesting and beautiful work - congratulations @SendkerFL and the whole team!!

If there are two things I love they are protein dynamics and NMR - such a ferocious study - really beautiful and well done to the whole team! @DFlemmingHansen @bhu_vaibhav @SiemonsLucas

In our latest paper @PNASNews a tour-de-force analysis of #NMR CPMG data by @bhu_vaibhav shows, for mutants of HDAC8, that changes in enzymatic activity and inhibitor potency are all captured in the structural dynamics. @UCLLifeSciences @SiemonsLucas https://t.co/oLFSarDh7b

Our #NMRchat DNNs are now able to transform crowded HSQC spectra of large proteins (<350 kDa) into spectra akin to Methyl-TROSY (methyl-TROSY-fication). Read the full story on bioRxiv: https://t.co/4hQvq8IPDV @EPSRC #DeepLearning @UCLLifeSciences @gogulan_k @bhu_vaibhav

We used #nativeMS electrospray ion beam deposition (ESIBD) to make samples for #cryoEM: mass-filtered, soft-landing deposition, cold substrate, in-situ ice growth, clean+cold transfer...we find... @ESIBDLab with many colleagues @OxfordChemistry @KavliOxford #structuralbiology

If you’re gonna see Queen Beyoncé you must know the lyrics to Heated.

Certain structures (e.g. some carbohydrates) are notoriously immunorecessive. Check out our latest preprint describing a germline ‘reach-through’ model for glycan-specific B cell activation. https://t.co/b86IAEOtrs (1/4)

https://t.co/ShVDKYnBS3

BT made £1.3bn, gave £750m to shareholders and the CEO got £3.5m. We have members using foodbanks. Today BT announced £400m profit for 1/4 year. Tomorrow our members strike for the first time since 1987 and have been subjected to extreme intimidation. RT if you back them.

Royal Mail Group profits £758m Shareholder payout £400m Paying TWO CEOs £2m + Imposed 2% on loyal postal workers who kept the country connected during the pandemic. They’re using Swiss banks whilst our members use foodbanks. Ballot result Tuesday. RT if you back us.

@charliebuchanan’s (and other colleagues/collaborators) work being described by Ben Davis. @KavliOxford

Pembroke Chemistry Tutors, Prof Andrew Baldwin & Prof Ben Davis have collaborated with DPhil student @charliebuchanan on a new research paper which has been published in @ScienceMagazine! Read more here: https://t.co/qa0vMHEd4g

A study of #SARSCoV2 finds evidence for a sialoside binding site in the early-pandemic B-origin lineage. Binding is lost in later, more transmissible variants, consistent with hypotheses that such sites can vary and may contribute to fitness. #glycotime https://t.co/fTIxPjrNmf

This was a huge international collaboration with far too many people to thank individually so please forgive me for a broad thank you to everyone involved! #glycotime #NMR @nmr900 @ScienceMagazine @RosFrankInst @KavliOxford @OxfordChemistry @PembrokeOxford @UniofOxford

We are making the uSTA workflow openly available to academics - we hope it becomes a widespread tool to unpick interactions between big and small molecules.

We think this might be related to how the virus hops species. There’s tonnes more in the paper including genetics, heparin and a lot of NMR... You have a choice of abstract, summary or the full paper (+ supp!) so have a read!😁

When the variants of concern became prevalent, we noticed mutations around our binding site, so probed them with uSTA: sugar binding vanished!

A crack team at the @RosFrankInst got a super high-resolution structure of spike with sialic acid (the sugar of interest) bound to the NTD. Comparison of cryo-EM and NMR poses gave excellent agreement.

uSTA is easily scalable, so we studied a panel of natural/unnatural sugars. These showed an ‘end-on’ binding pose for sialoside ligands in spike, which was remarkably similar to the influenza HA pose. But how did we confirm our new method was accurate?