vaibhav shukla
@bhu_vaibhav
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I am a structural biologist using NMR spectroscopy to understand the drug target protein.
London, England
Joined January 2016
Here is our latest manuscript on the significance of protein enzyme #dynamics in the #cancer drug target Histone de-acetylase 8, studied by #NMR CPMG experiments. 🧲🧪 @ismb_london @uclbiosciences @ucl
In our latest paper @PNASNews a tour-de-force analysis of #NMR CPMG data by @bhu_vaibhav shows, for mutants of HDAC8, that changes in enzymatic activity and inhibitor potency are all captured in the structural dynamics. @UCLLifeSciences @SiemonsLucas
https://t.co/oLFSarDh7b
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P-035 is the poster number @euromar2023 and page number is 238. Looking farward to discuss with the protein NMR enthusiasts.
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Excited to share my poster titled "Conformational dynamics dictate Histone de-acetylase activity and inhibitor potency" to be presented @euromar2023
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Our new manuscript. An NMR application to IDP-Drug interaction.
Need to drug an intrinsically disordered protein (#IDP)? Why not try 19F #NMR transverse spin-relaxation? Check out our most recent work, now on @biorxivpreprint. @DFlemmingHansen @bhu_vaibhav @FigueiredoAm #NMRchat 🍝 💊 🧲 A 🧵👇🏽: (1/14) https://t.co/GDvM3HyI0h
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Check out our latest paper, now online in @eLife! Together with @hofmann_hagen we characterized Hsp40's binding to tau, affecting fibrillar aggregation. https://t.co/Orl3V7XRZy
elifesciences.org
Chaperones from different families and classes synergistically target different stages of tau aggregation, thus preventing pathological amyloid formation.
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