Anuvab Das
@anuvab_chem
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Asst. Prof. in CCEB at @NTUsg | Former Postdoc with @francesarnold at @Caltech | PhD in @Powers_Lab at @TAMU | MSc at @IITKgp
Singapore
Joined August 2009
I’m thrilled to share that I have joined the School of Chemistry, Chemical Engineering and Biotechnology (CCEB) at NTU Singapore as an Assistant Professor! https://t.co/i2zgX4C9qg
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Really happy to see this published in its final form @J_A_C_S! 🧬 In this paper, we introduce a new class of biomimetic receptors to host functionality in synthetic cell membranes Elita Peters @dianatanasedt @DiMicheleLAB1
https://t.co/Tv3qUAvU9T
pubs.acs.org
Biological cells use cations as signaling messengers to regulate a variety of responses. Linking cations to the functionality of synthetic membranes is thus crucial to engineering advanced biomimetic...
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We will soon have an opening in our group as part of a joint PhD program between NTU and Sorbonne University (36 months in SG, 12 months in Paris). Start date can be either in Jan or Aug 2026. Reach out if you're interested or know prospective candidates!
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Excited to share that I’ll be joining the University of Tennessee Knoxville as an assistant professor this fall! I’ll be looking for grad students and postdocs—if you’re into theoretical chemistry or materials science, feel free to reach out (sayan@caltech.edu)
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I'm excited to embark on this new chapter of my life — building my own lab, mentoring young scientists and contributing to science.
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A big thank you to @NTUsg for this opportunity and to my mentors — @francesarnold, @Powers_Lab, @Francois_Gabbai, and @SarbajitBanerj1 — for their unwavering support!
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Happy to share that our work on Active Learning-Assisted Directed Evolution is now published in @NatureComms! We show that it's an effective and broadly applicable method to accelerate protein engineering with machine learning. Paper:
nature.com
Nature Communications - Directed evolution is a powerful method to optimize protein fitness. Here, authors develop an active learning workflow using machine learning to more efficiently explore the...
Excited to share our preprint on Active Learning-Assisted Directed Evolution (ALDE)! We present a practical workflow that leverages uncertainty quantification to efficiently navigate protein fitness landscapes. 🧵(1/6) Paper: https://t.co/fME23B3Q0x Code:
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🚨🚨Our lab is hiring a colleague Postdoc on quantitative imaging biology! Join us if you like imaging, biophysics, STED & cell interfaces on complex epithelial tissue! Details below! :) #pdra #hiring #postdoc #condensates #quantitativebiology #imaging # https://t.co/dtvw6qrYji
opportunities.rfi.ac.uk
The Rosalind Franklin Institute is a new national institute, announced in 2017 by the UK government, dedicated to bringing about transformative changes in life science through interdisciplinary...
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🔊Job Alert🔊 #postdocposition PIs #share Interested in Postdoc opportunities in Synthetic Main Group & Organometallic Chemistry? We have a funded #postdoc position available in our group to work on multiple exciting projects on Small Molecule Activation at @iitgn Gandhinagar
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Check out how Edwin has evolved a protoglobin to synthesize non-canonical amino acids/esters. Congratulations to @alfonz___ and the whole team!
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Never underestimate a diiron enzyme. Congrats @sanjoyadak90 for bringing the nitrile synthase AetD to life with @Drennan_lab, Maria-Eirini Pandelia, and Ken Houk labs. Published today @NatureChemistry
nature.com
Nature Chemistry - Nitrile-containing molecules and their biosynthetic enzymes are uncommon in nature. Now, a nitrile-forming diiron enzyme involved in the biosynthesis of aetokthonotoxin—the...
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We are HIRING! Olaf @SECLab_MPI_CEC and I are teaming up together with Serena to hire a postdoc/PhD for projects on Spectroelectrochemistry with metalloenzymes like LPMO and Nitrogenase. Check the link! RTs, please! #hiring #Postdoc #Chemistry #PhD
https://t.co/HINHIefndy
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Happy to share that our work "A combinatorially complete epistatic fitness landscape in an enzyme active site" by myself, @patrickalmhjell, @EllaWD_PhD, Grace Liu, @NJP_Chem, @jsunn_y, and @francesarnold is now out in @PNASNews! (1/15) https://t.co/Xnl6f1mmNM
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Excited to share our preprint on Active Learning-Assisted Directed Evolution (ALDE)! We present a practical workflow that leverages uncertainty quantification to efficiently navigate protein fitness landscapes. 🧵(1/6) Paper: https://t.co/fME23B3Q0x Code:
biorxiv.org
Directed evolution (DE) is a powerful tool to optimize protein fitness for a specific application. However, DE can be inefficient when mutations exhibit non-additive, or epistatic, behavior. Here, we...
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Stop by our poster “Feature Reuse and Scaling: Understanding Transfer Learning with Protein Language Models” tomorrow (Poster Session 5, Thu 11:30 AM - 1 PM, Hall C 4-9 #313) @icmlconf #ICML2024 Paper: https://t.co/6DxRJKuYjp
@avapamini @yisongyue @KevinKaichuang @alexijielu
proceedings.mlr.press
Large pretrained protein language models (PLMs) have improved protein property and structure prediction from sequences via transfer learning, in which weight...
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Special shoutout to my brilliant co-authors @Shilong_Gao, @raviglal, @HicksChemistry and @PaulOyala for helping me get this project across the finish line, and to @francesarnold for giving me the opportunity to work on such exciting bioinorganic problems!
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The {FeNO}7 species also prompted us to investigate metabolic pathways that contain NH2OH and NO as intermediates, such as the nitrite reductase pathway. This ultimately led to the discovery of using nitroxyl (HNO), nitric oxide (NO), and nitrite (NO2–) as new aminating reagents.
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During our investigation of the NH2OH-mediated aminase cycle, we characterized an S = ½ species using EPR, identifying it as a six-coordinate iron-nitrosyl {FeNO}7 intermediate. The selective amination reactivity indicates that the {FeNO}7 species is an on-pathway intermediate.
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On our venture to mechanistically understand the NH2OH-mediated C–H amination, we found that the catalysis goes through a nitrenoid radical intermediate, as evidenced by room temperature spin-trap EPR and HR-ESI-MS of the aminated spin-trapped product.
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I am excited to share our latest discovery which is out now in @J_A_C_S! This study uncovers how engineered hemoproteins can leverage biological nitrogen cycle intermediates for enzymatic C–H amination, opening new paths towards sustainable synthesis. https://t.co/H3jzx6c49h
pubs.acs.org
Engineered hemoproteins can selectively incorporate nitrogen from nitrene precursors like hydroxylamine, O-substituted hydroxylamines, and organic azides into organic molecules. Although iron-nitre...
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