Hiroshi Yasuda (保田浩志)
@Yash25571056
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Scientist & Professor (科学者&教授). Tweet is a soliloquy based on my personal views (ツィートは個人の見解に基づく独り言です).
Hiroshima, Japan (広島, 日本)
Joined March 2019
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The advanced intelligence of humans is given to improve the status of future generations.
If we use this prominent power only for our own generation, we will undergo degeneration.
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"[The main symptoms of the new Omicron strain EG.5.1] are a sore throat, a runny nose, a blocked nose, sneezing, a cough without phlegm, a headache, a cough with phlegm, a hoarse voice, muscle aches and pains and an altered sense of smell..
However, shortness of breath, a loss…
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We are observing that more people are dying with COVID under the slogan of "living with COVID."
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Let me post a gentle reminder.
SARS-CoV-2 is a novel virus repeats wave-like successive attacks with 4-6 months intervals.
The damage from the first infection may look mild, but the cumulative damage from the repeated attacks could be deadly.
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"Of more than 665 million cases worldwide, nearly 1 in every 2 people with COVID-19 is at risk of developing Post-COVID-19 Neurological Syndrome (PCNS).. PCNS mimic some of the symptoms after a stroke and younger adults seem to be at particular risk."
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The current COVID-19 viruses are neurotropic.
Every infected person will probably experience a progressive weakness to a greater or lesser extent.
If the (re)infections continue at this rate, we will see a progressive weakness of the human society in not-so-distant future.
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Mass cognitive decline, i.e., loss of collective intelligence, causes a dramatic societal collapse of our society.
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SARS-CoV-2 takes the lives mostly of aged people and ages the bodies mostly of young people.
As a consequence, we would see a gradual but significant drop of humans' life expectancy over next decades.
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Those who got vaccines and are attending crowded gatherings look similar to those who got diabetic medications and are eating large cakes.
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The brain damage caused by SARS-CoV-2 may not be recognized as a serious problem for the person who hasn't used much the frontal lobe.
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As a gentle reminder, let me write down below what we don't know yet about COVID-19 as of August 2022.
- Symptoms that could appear more than 3 years after infection;
- Exact durations & progressions of various long COVID symptoms;
(continued)
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I think that the most dreadful effect of COVID-19 for humankind is mass cognitive decline which leads to a collapse of our civilized society.
It is hard to prevent its progression, because the people who have got cognitive declines unrecognize that they have cognitive declines.
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We may not die of COVID but will die earlier with COVID.
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Most common symptoms of the post-COVID-19 neurologic syndrome reported from 3,762 participants were as follows:
- Brain fog (85%)
- Difficulty thinking (65%)
- Short-term memory loss (65%)
- Long-term memory loss (36%)
- Difficulty with word finding (46%)
(continued)
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Let me post another gentle reminder:
Those who got COVID-19 have increased risks of
350% Alzheimer's disease;
260% Parkinson's disease;
270% ischemic stroke; and
480% intracerebral hemorrhage (bleeding in the brain).
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Previously, I envisaged that the modern civilization could collapse by either a nuclear war or a deadly infectious disease.
Currently, I presume that the collapse will be caused by the secular decline of cognitive functions of those infected repeatedly with the "mild" viruses.
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Wearing a mask indoors when the virus is spreading is like wearing a hat outdoors when the sun is shining.
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Any society where children cannot grow in good health is already unsustainable.
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At a high school in Fukuoka, Japan, a quarter of the students (238 out of 939) are absent as of today (July 18). Of these, 39 students have been confirmed to be positive for COVID-19, and the other 199 have some symptoms such as fever. The school has decided to close over this…
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"..fungal infections appear to have increased as a result of Covid.. Because these infections are more common in people with suppressed immunity or lung damage, doctors suspect they are capitalising on the physical damage wreaked by Covid."
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COVID-19 is a communicable disease that causes non-communicable diseases (heart failure, stroke, diabetes, etc.).
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People will gradually weaken and shall gradually recognize that COVID gradually ruins their health.
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I'd say EG.5 (Eris) is the worst virus ever.
As it causes only mild acute symptoms (dry cough, running nose, etc.), many people don't realize their infections to SARS-CoV-2, don't go to hospitals/get PCR tests, don't care about spreading the virus, and then get seriously ill…
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You may have no problems in living with COVID, if you don't mind losing some of your body or brain functions.
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One of my biggest concerns as to repeated SARS-CoV-2 spreading is the brain damage of children, more exactly the impaired development of their central nervous systems.
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The Chinese experts seem to have known well what would really happen later if they allowed the SARS-CoV-2 virus to spread.
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Keep your friends close, and your N95 masks closer.
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The SARS-CoV-2 variants seem to have a common mission of shortening the healthy life expectancy of humankind.
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In near future, we will get a novel SARS-CoV-2 variant which does not induce any symptoms (fever, cough, nausea, etc.) at the time of infection, but causes chronic health problems (fatigue, poor sleep, mental disorder, etc.) from few weeks later.
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At a clinic in Okinawa, "a hospital for an emergency patient cannot be found even after visiting 7 or 8 hospitals. The life-threatening situation is continuing, which can be called a medical collapse rather than a medical crisis.. Two-thirds of the patients are fevered older…
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Our current situation with the COVID-19 virus is similar to that with microplastics.
We cannot remove what has already been spread, but can reduce what is being spread from now on.
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In Okinawa, Japan, the number of hospitalized COVID-19 patients has reached the level of medical care crisis in the week of June 5-11 and are currently approaching the upper limit above which a collapse of the medical care system would occur.
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The variant which does not kill us makes us weaker.
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I'm now worrying about the new pandemic, so-called "Covian flu", caused by combination of SARS-CoV-2 and H5N1 which would mutate to be a human-transmissible, highly pathogenic avian flu virus.
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n 2021, the main meaning of "Living with COVID" was "Living with more deaths".
In 2022, it has changed to "Living with more disabilities".
In 2023 or later, it will change to "Living with more societal collapses".
I like to avoid the next stage, honestly.
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In the long run, the smartest way of living for humans is to keep clean air, safe water, rich soil and the ecosystem that provide those.
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Long COVID has 4 major subtypes dominated by:
1. heart, kidney & circulation symp. (34%);
2. respiratory & sleep problems, anxiety, headache & chest pains (33%);
3. musculoskeletal & nerve symp. (23%); and
4. combined digestive & respiratory symp. (10%).
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If you are cognitively damaged, you would not recognize that you are cognitively damaged.
That's the problem right there.
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SARS-CoV-2 gradually make us dumber, but we cannot realize it well because we have gradually become dumber.
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The spread of Eris (EG.5.1) would divide the people into two groups: those who say we should be more careful not to catch COVID-19 and those who say we don't need to care since COVID-19 is just a cold.
I should note that Eris is the goddess of strife and discord.
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"People with shingles have an approximately 80% higher risk of stroke.. this risk stays elevated for up to a year.. Stroke risk is nearly doubled for those with the rash on their face, and tripled for those under the age of 40."
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"At least 65 million individuals around the world have long COVID.. the number is likely much higher due to many undocumented cases.. Long COVID is associated with all ages..the highest percentage of diagnoses between the ages of 36 and 50 years."
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This morning I heard as a shock that my colleague in Tokyo passed away on January 5th at the age of 63 after having contracted COVID-19 on December 23rd (12 days before).
I've had a hard time believing it, since he was so active and energetic in a web meeting one month ago.
He…
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As of yesterday (July 25), the number of COVID-19 cases in Japan was estimated to be nearly120,000, and its positivity rate was nearly 50%.
I should note that other infectious diseases (herpangina, RSV, hand-foot-and-mouth disease, etc.) also have been notably increasing in…
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Cognitive impairment will be more difficult to be recognized by yourself if you get the cognitive impairment.
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As you may have heard before,
"..more than three-quarters (nearly 80%) of people with long COVID we studied had POTS (Postural orthostatic tachycardia syndrome). Multiple studies, including our own, have shown viral infection is the most common trigger for POTS.
We suspect some…
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In Japan, the excess deaths have notably been incerasing and the population has notably been decreasing.
I'm sure that Japan is now in a state of war against SARS-CoV-2, with a concern that many people seem to be cognitively impaired.
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The only thing better than preventing reinfections is preventing the first infection.
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More and more people seem to forget that SARS-CoV-2 infection can cause memory impairment.
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Preventing is more effortless than recovering, generally.
Pretending looks more effortless but will have more distressing consequences, actually.
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In the middle of the COVID-19 pandemic, I see a general tendency that politicians are caring about the past, citizens are concerning about the present, and scientists are worrying about the future.
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"SARS-CoV-2 is a highly neuroinvasive neurotropic virus.. SARS-CoV-2 could cause damage to the CNS that may substantially increase the incidence of neurodegenerative diseases and accelerate the progression.."
It's a risky gamble to repeat infections.
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Now I feel that the main target of SARS-CoV-2 virus is the advanced intelligence of humans.
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The more people sicken due to SARS-CoV-2 infection, the less people care due to cognitive decline.
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According to Dr. Koichi Hirahata, Director of the Hirahata Clinic (Shibuya, Tokyo), who has treated about 6,000 Long COVID patients, he has treated about 100 patients per day, feeling that there are no signs of decline.
At the Clinic, the main symptoms of Long COVID caused by…
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Omicron increases brain fog.
So, many people easily forget that Omicron increases brain fog.
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It must be the first attempt in human history to adopt the mass infection policy in the middle of pandemic.
And it will be the last attempt.
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- Infectivity & virulence of new (sub)variants;
- Exacerbation caused by reinfections;
- Possible synergistic effects of infections with other virus/bacteria;
- Long-term effects on the physical, mental & social development of small children.
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"Less than six months after the infection, some (COVID-19) patients had lost up to 2% of brain volume & gray matter thickness.. 2% is almost ten times greater loss than that experienced every year by older adults due to normal aging."
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Currently in Japan, more and more people are feeling sick. They don't get tested and come to office/school with coughs after a ~3 days off from work.
On the other hand, it is reported that the viral load in the body after an Omicron infection peaks on the 4th/5th day after the…
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Long Covid cannot be overcome by the warrior spirit.
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According to a systematic review on the COVID-19 survivors, "Seventy-nine percent of COVID-19 survivors at 1 months and 75% at 3- and 6-month follow-up showed cognitive impairment.."
3 in 4 is a quite high ratio.
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この記事によれば、オミクロンの新しい亜種EG.5.1の主な症状は、喉の痛み・鼻水・頭痛・痰のある咳・しわがれ声等であって、発熱は主な症状ではないとある。
この情報が正しければ、新型コロナ患者を発熱外来で検査・同定している現在のやり方は不適切であると思う。
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These days I feel that "living with COVID" could be rephrased as "killing by omission".
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It is highly recommended to avoid infection with a novel virus unless you know how to recover.
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Saying "COVID-19 is like flu" is similar to saying "monkeypox is like chickenpox".
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SARS-CoV-2 appear to have been given a master key by nature to enter any cells of human as they like.
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”When scientists infected brain organoids with the virus that causes COVID, they found that not only does it spread in neurons in the brain, it also accelerates the destruction of connections between neurons called 'synapses'..
Synapses are responsible for all the functions of…
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After getting COVID, I've realized that rushing makes my life shorter.
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WHO released an updated laboratory biosafety guidance related to COVID-19.
In this interim guidance, SARS-CoV-2 is classified as a Biosafety Level 2 (BSL-2) agent.
Moderate-risk agents such as HIV and Salmonella, are assigned to this level.
This implies that modern people are no…
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People tend to forget that SARS-CoV-2 infection causes memory impairment.
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We need to find a way to repair the brain function damaged by SARS-CoV-2, before all of our brains become non-functional.
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"SARS-CoV-2, the virus that causes COVID-19, can directly infect the arteries of the heart and cause the fatty plaque inside arteries to become highly inflamed, increasing the risk of heart attack and stroke..
the virus infects and replicates in the arteries no matter the levels…
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"Given these findings, I am confused as to why the Centers for Disease Control and Prevention and our local public health authorities..are not widely sharing information about the risks of long covid, encouraging us to prevent every possible infection..
High-quality masks and…
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"[Now] at least 65 million people worldwide are estimated to have post-acute sequelae of COVID-19 (long COVID).. On May 5, 2023, WHO announced that COVID-19 no longer constitutes a public health emergency of international concern. However, the post-acute sequelae of COVID-19 are…
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HIV-1 (the most common type of human immunodeficiency virus) and SARS-CoV-2 "target the respective endothelial and hematopoietic stem-progenitor cells to thrive upon the relevant host cellular surrounded stromal microenvironments by adopting reciprocally-driven mechanistic…
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In US, "By the second year of the pandemic, the dramatic increases in heart attacks blew apart the models.. Fatal heart attacks among adults ages 25-44 soared 29.9% over what was predicted."
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In Okinawa, hospitalized COVID patients steadily increase. The hospital beds dedicated to those patients are almost full, making it difficult to accept new patients for many hospitals.
Dr. Yamauchi (Yuai Medical Center in Okinawa), said, "It's like the last year's hellish…
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Those who give up health in order to get free will lose both in the long term.
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I've learned from the pandemic that people learn nothing from a pandemic.
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Humans are getting COVID en masse, like jumping off cliffs en masse.
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Infection occurs in seconds, sequela lasts for years.
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Prof. Hirata (Nagoya Inst. Technol.) reported that COVID infection had increased the health risks as follows:
- Myocardial infarction: 10.7-24.6 times;
- Heart failure: 6.6-10.4 times;
- Venous thrombosis: 26.1-53.1 times;
- Diabetes: 6.3-8.4 times.
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They made it.
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It looks a simultaneous global infection..
The infectivity of BA.5 is astounding.
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In Japan, more and more people are getting sick this summer, with a continuing situation far exceeding the capacity of medical institutions.
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A team in Italy has now identified another receptor (other than ACE2), called RAGE, present on the surface of certain human immune cells, which can bind to SARS-CoV-2 and allow it to enter cells..
the activation of the RAGE receptor in monocytes, a type of white blood cells, was…
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From my experience, I think that SARS-CoV-2 can slightly disturb functioning of the autonomous nerve and then gradually deteriorate the quality of life.
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I presume that the guys who don't like wearing masks don't like wearing condoms either.
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I can imagine with sorrow that our children would say, "The COVID-19 was deadlier than WWII".
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A: "SARS-CoV-2 induces hyperinflammation."
B: "That's scary."
A: "It causes multiorgan failure or death."
B: "Terrible. Why doesn't everyone avoid it?"
A: "Furthermore, the virus causes..."
B: "Excuse me, I have to go for a dinner party. Let's continue after that."
A: "...…
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"A 53-year-old woman was admitted with an altered state of consciousness for 8 hours. Two months earlier, she experienced slurred speech following a COVID-19 infection..
Neurological examination on admission suggested coma, hypertonia of extremities, and bilateral positive…
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The opposite of hospitalization is not recovery. It’s long COVID.
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As of October 2022, where there is a sore throat, there may be SARS-CoV-2.
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"..in the case of frozen beef and mutton, SARS-CoV-2 survived for over two months at -20°C, with only a minimal 0.5 log TCID50 (50% tissue culture infectious dose) reduction in viral load during storage..
The virus has persisted in chicken, salmon, and other seafood for >28…
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From an autopsy study of eyes, "SARS-CoV-2 RNA was found in neuronal cells of the retina, ganglion cells, corneal epithelia, scleral fibroblasts, and oligodendrocytes of the optic nerve in all 21 patients.
Common histopathological findings associated with infection included…
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"The concern is that people will be less able to hold off future bugs and pathogens like influenza, or that unsettled immune systems could lead to an increase in diabetes and other auto-immune diseases.. Their white blood cells were unrecognizable..”
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SARS-CoV-2 can silently infect most of our organs/tissues.
This fact already scares me.
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In the COVID era, the vulnerable people die earlier, the remained ones become vulnerable earlier.
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