Alex
@alexwong2023
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Light-Deactivated Fluorescent Probes (FLASH-Off) for Multiplexed Imaging @MGH_RI
@HMS_SysBio @elias_halabi_ @harvardmed @harvard @MGHMedicine @WeisslederLab #Fluorescent #Probes #Multiplex #Imaging
pubs.acs.org
Highly multiplexed, cyclic fluorescence imaging has advanced our understanding of the biology, evolution, and complexity of human diseases. Currently available cyclic methods still have considerable...
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Nonnegative spatial factorization: a general framework for spatially-aware and interpretable dimension reduction for high-dimensional spatial data, and its application to spatial transcriptomics analysis. @BeEngelhardt @will_townes OA paper:
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From the Kerr lab: A light-weight three-photon miniature microscope allows imaging neuronal activity throughout the cortex in freely moving mice. https://t.co/0oGHjxLUGP
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Very excited to share my latest publication: "Deep learning enables reference-free isotropic super-resolution for volumetric fluorescence microscopy" https://t.co/Uz9LNHJBqU……. We demonstrated our method using confocal FM and light-sheet FM. #MachineLearning #Microscopy
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In between all the amazing lectures and labs, found a little bit of time to play with this old timey centrifuge at @MBLScience. Very cool and slightly frightening. #Embryo22
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scMinerva: a GCN-featured Interpretable Framework for Single-cell Multi-omics Integration with Random Walk on Heterogeneous Graph https://t.co/gj7rw9nSDR
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I made some time to write two mini-tutorials on how to analyze action potentials in Clampfit and Python. I hope this can be useful for beginners. Let me know if you have any suggestions to improve these tutorials. Thanks! https://t.co/MvhRPwSijl
spikesandbursts.wordpress.com
— Last updated on December 15, 2024 — The patch-clamp technique was initially designed by Neher and Sakmann (1976) to study the currents going through single ion channels. The technique was later i…
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Out today from @bewersdorflab! Two-color fluorogenic DNA-PAINT introduces self-quenching, kinetics-optimized probe designs. This approach improves imaging speed 26-fold and eliminates the need for optical sectioning. https://t.co/Q7edlPba4w
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📢 @MurthyLab @shaevitz and I are excited to announce 📢: SLEAP, our multi-animal pose tracking system, is now out in @naturemethods! Paper → https://t.co/lO53o4jCga Download + docs + data + more → https://t.co/Ue7pccY6Tm Read on to learn what’s new!
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#LAMAs are out! A new molecular tool for controlling proteins.
Check it out: a nanobody for GFP that can be switched on and off with small molecules, from the Johnsson group. https://t.co/XqMTb9yWu1
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Work from my PhD @HilliardLab @stcoakley is out! In collaboration with @AnggonoLab and Rumelo Amor, QBI microscopy manager. We identified a new target for axonal fusion, which is a rapid and efficient mode of axonal repair in worms. @QldBrainInst 🧵 1/5 https://t.co/8m4EWVFNXo
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Mitochondria (blue) and intermediate filaments (vimentin, orange) in a tissue culture cell. 7ish minute loop. Imaged with airyscan.
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Rivers could generate thousands of nuclear power plants worth of energy, thanks to a new ‘blue' membrane
science.org
Boron nitride nanotube membrane creates power by controlling the flow of electrically charged ions in water
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For so long, I’ve looked for MD/PhD students & professionals who don’t want to pursue the typical academia/paper pushing route—people who care about connecting with communities & redefining success in research. But maybe I should stop looking and just be what I haven’t seen.
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Going to mix ‘n’ match your booster shot? According to the NIH, these are the results to expect depending upon what your initial vaccine was, and what booster you go with.
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Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging https://t.co/TzmeOhLtnj
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#humansinimaging - Meet Tim Hanson: @m8ta is a senior scientist at @HHMIJanelia’s jET. He builds tools 🔬🔧 for biomedical research 🧬🦠🧫. Here, he stands next to his latest microscope, a compact & modular #adaptiveoptics (AO) unit for high-resolution imaging of 🐁😀 #microscopy
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