Adam Glaser
@adam_k_glaser
Followers
3K
Following
3K
Media
152
Statuses
2K
Developing hardware + software tools for large-scale imaging @AllenInstitute for Neural Dynamics.
Seattle, WA
Joined August 2016
How do you image the large and the small at the same time? We developed new 🔬 technology to image centimeter-scale specimens - including whole mouse brains 🧠 - with diffraction-limited resolution and without sectioning. #mesoscale #imaging. 🧵 (1/n)
30
197
617
First 3200 MP images from the LSST at the Vera C. Rubin Observatory!.
nature.com
Nature - The Rubin Observatory in Chile will map the entire southern sky every three to four nights.
1
0
7
RT @RetoPaul: The MOSAIC reconfigurable microscope by @Eric_Betzig et al is finally out! . MOSAIC integrates multiple advanced imaging te….
0
54
0
High-throughput line scanning confocal microscopy.
biorxiv.org
Recent advances in high throughput optical microscopy have achieved whole-organism scale imaging at diffraction-limited resolutions. Current microscopes, however, require making compromises between...
0
6
29
We are excited to share our development of a new 10X lens with NA=0.50 over a 7.2 mm FOV and a 35 mm working distance (water), fully corrected from 400-850 nm. This lens will power our upcoming ExA-SPIM "2" and is available for dissemination - please get in touch if interested!
7
19
124
To look into: a Python alternative to ZEMAX.
github.com
Comprehensive optical design, optimization, and analysis in Python, including GPU-accelerated and differentiable ray tracing via PyTorch. - HarrisonKramer/optiland
0
17
58
New review out on imaging 3D cell cultures. Congratulations to Huai-Ching and @jonliu123 on leading this excellent new review!
nature.com
Nature Methods - This Review discusses current 2D and 3D microscopy methods for imaging three-dimensional cell cultures and emerging strategies to address key challenges.
0
6
39
Thermal Lensing Effects in Light-Sheet Microscopy.
arxiv.org
In light-sheet fluorescence microscopy (LSFM), the axial resolution is governed by the illumination beam profile, motivating the development of advanced beam-shaping techniques to enhance imaging...
0
2
13
RT @thisisEJKoh: I’m catching up on good news. THE LIBERATORS is a 2025 Pacific Northwest Book Award Finalist for Fiction. Thanks to @paci….
0
4
0
Sound-sheet microscopy - in this study, we introduce nonlinear sound-sheet microscopy (NSSM), a method to image targeted biological functions across cubic centimeters of opaque living tissue.
science.org
Light-sheet fluorescence microscopy has revolutionized biology by visualizing dynamic cellular processes in three dimensions. However, light scattering in thick tissue and photobleaching of fluores...
0
12
46
Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue.
biorxiv.org
Light sheet microscopy is the ideal technique for multiscale imaging of large and cleared tissues, and it is desirable to achieve the highest possible isotropic resolution across the entire sample....
1
11
54
RT @JohanWinn: 🚀 We are looking for Image Data Scientists to join our mission to advance connectomics towards whole brain scale for humans….
0
36
0
New 410 MP camera sensor coming in 2025 from Canon
global.canon
TOKYO, January 22, 2025—Canon Inc. announced today that it has developed a CMOS sensor with 410 megapixels, which is the largest number1 of pixels ever achieved in a 35 mm full-frame sensor.
2
0
13
Software folks. What web based multi scale image viewers exist? Aware of neuroglancer, viv, openseadragon, zoomify, are there others?.
0
1
3
RT @RetoPaul: Okay, here is the belated Xmas present for OPM and SCAPE drivers. Deliberate aliasing and recovery to speed up 3D acquisitio….
0
5
0
First imaging experiment with our new ExA-SPIM software… fingers crossed for no dropped frames or crashes! 😅
1
4
36
Christmas came early. Thank you to @ximeagmbh for sending this prototype camera with the upcoming 246 MP Sony IMX811 sensor! Excited to start testing.
2
3
33
Very exciting updates from @Andrew_C_Payne and @E11BIO. Excited to see future developments and progress and how imaging/microscopy advances can help push this to the exascale!.
E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 🧵
0
6
18
RT @hiroking1975: #拡散希望 当研究室からNature Protocols誌に新しい透明化技術論文を発表。ハイスループットな透明化・染色・解析パイプラインが可能に。秋山さん、松本さん達の仕事です。おめでとうございます。興味がある方は、PR→. https://t….
riken.jp
理研らの共同研究チームは、ハイスループットで簡便なマウス臓器まるごとの透明化、染色、3Dイメージング、データ解析手法を開発しました。
0
52
0