RT @atptour: Someone call a historian, this match is one for the BOOKS 📚. #RolandGarros #sinner #alcaraz

RT @CD1MR1: Our third webinar from the AUS/APAC region, will feature Nick Gherardin and Sho Yamasaki. Thursday, June 12th at 17:00 AEST (8….

RT @CD1MR1: Our second webinar hosted from USA, will be by Laurent Gapin and Antonia Rotolo. Thursday, February 6th at 16:00 GMT (8:00 Pac….

RT @LabWaggoner: Role for γδ T cell-derived IL-4 in initiating CD8 T cell immunity to Plasmodium.@Lynette_Beattie h….

RT @TheDohertyInst: 💪 New immunity research published in the Journal of Experimental Medicine highlights how the body keeps its prompt immu….

RT @JExpMed: Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling. New study from Calvin Xu,….

RT @WaelAwadMoh: Sharing our latest work @PNASNews.MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells.We pos….

We're incredibly stoked and honoured to have Fabio Grassi's commentary on our paper - this work has built on many of his team's findings and body of work, in the nexus of purinergic control of T cell activation and function! 🌟.

Huge thanks to all our collaborators including @LMackayLab @Lynette_Beattie @JeffreyYWMak and those not on here, across @TheFlorey @UQ_News @UniMelbMDHS labs!.

Conceptually, non-peer review'd diagram here: Within T cells at least, integrating thoughts posed by labs of P.Brennan, B.Jabri, perhaps the extent of tissue damage sensitivity could be a hallmark of the ‘T cell-innateness’ theory.

Overall, these have implications to how we should move away from studying our T cell lineages in isolation, and the role of T cell IL-4 production that is now getting resurged attention.

For discussion, this sensing of damage metabolites may act to prevent excessive tissue inflammation and injury as a way to maintain tissue homeostasis from the explosive cytokine production from these innate-T cells, UNTIL there is cognate antigen for them involved.

@JExpMed Our data indicates that upon insult, release of tissue damage metabolites drives this P2RX7-mediated depletion of T-bet+ innate-T cells, +uncovering more numbers & subsets (CD4 innate-like IFNg/IL-4++ anyone?) than we thought originally exists. Also raising the q of 'why them'?.

@JExpMed This all started in the quest of trying to recover enough numbers of NKT/MAIT/gdT cells ex vivo, why do (some) of them die so easily?? We followed the literature & the correlation of P2RX7 (not other P2RX's) expression on innate-like T cells was a key, in both mice and humans.

Sharing our latest work @JExpMed! We've uncovered that P2RX7 regulates unconventional T cells selectively, particularly subsets that co-produce IFN-γ & IL-4. Hoping this helps more discoveries in the role of these innate-like cells, using inhibitors from the P2RX7/ARTC2 field!.

RT @JExpMed: Xu, @_fernace et al. @TheDohertyInst reveal that the ARTC2–P2RX7 regulatory axis is a key modulator of unconventional T-cell s….

RT @SomeBlondeSci: Such an inspiring morning spent celebrating the 2024 @LOrealAustralia @UNESCO Fellows! For 26 years now, L'Oreal have su….

RT @lynchielydia: Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolis….

RT @lynchielydia: A fantastic collaborative Department to work in, on a beautiful campus. Join us!.

Thank you Lucie and @JExpMed team for sharing our contributions, I've always enjoyed this illuminating series from many inspiring colleagues!.