
Fern Koay 郭
@_fernace
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👩🏼🔬🇲🇾🇦🇺🇺🇲🔬 Scientist in immunology @TheDohertyInst @UnimelbMDHS
Melbourne, Victoria
Joined October 2014
RT @atptour: Someone call a historian, this match is one for the BOOKS 📚. #RolandGarros #sinner #alcaraz
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RT @LabWaggoner: Role for γδ T cell-derived IL-4 in initiating CD8 T cell immunity to Plasmodium.@Lynette_Beattie h….
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RT @TheDohertyInst: 💪 New immunity research published in the Journal of Experimental Medicine highlights how the body keeps its prompt immu….
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RT @WaelAwadMoh: Sharing our latest work @PNASNews.MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells.We pos….
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We're incredibly stoked and honoured to have Fabio Grassi's commentary on our paper - this work has built on many of his team's findings and body of work, in the nexus of purinergic control of T cell activation and function! 🌟.
Grassi @LaStatale discusses new study by Xu, @_fernace et al ( which defines NAD-induced cell death via purinergic P2RX7 receptor in type 1 unconventional T cells, particularly intrahepatic MAIT cells pivotal in liver homeostasis
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Huge thanks to all our collaborators including @LMackayLab @Lynette_Beattie @JeffreyYWMak and those not on here, across @TheFlorey @UQ_News @UniMelbMDHS labs!.
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@JExpMed Our data indicates that upon insult, release of tissue damage metabolites drives this P2RX7-mediated depletion of T-bet+ innate-T cells, +uncovering more numbers & subsets (CD4 innate-like IFNg/IL-4++ anyone?) than we thought originally exists. Also raising the q of 'why them'?.
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@JExpMed This all started in the quest of trying to recover enough numbers of NKT/MAIT/gdT cells ex vivo, why do (some) of them die so easily?? We followed the literature & the correlation of P2RX7 (not other P2RX's) expression on innate-like T cells was a key, in both mice and humans.
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Sharing our latest work @JExpMed! We've uncovered that P2RX7 regulates unconventional T cells selectively, particularly subsets that co-produce IFN-γ & IL-4. Hoping this helps more discoveries in the role of these innate-like cells, using inhibitors from the P2RX7/ARTC2 field!.
In @JExpMed, Xu, @_fernace et al. @TheDohertyInst reveal that the ARTC2–P2RX7 regulatory axis is a key modulator of unconventional T-cell survival, showing how this pathway selectively influences innate-like, IFN-γ and IL-4 co-producing T cells.
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RT @JExpMed: Xu, @_fernace et al. @TheDohertyInst reveal that the ARTC2–P2RX7 regulatory axis is a key modulator of unconventional T-cell s….
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RT @SomeBlondeSci: Such an inspiring morning spent celebrating the 2024 @LOrealAustralia @UNESCO Fellows! For 26 years now, L'Oreal have su….
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RT @lynchielydia: Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolis….
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RT @lynchielydia: A fantastic collaborative Department to work in, on a beautiful campus. Join us!.
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Thank you Lucie and @JExpMed team for sharing our contributions, I've always enjoyed this illuminating series from many inspiring colleagues!.
The final instalment of our 2024 #WomenInSTEM Viewpoint series is now live! Get insights from women researchers across multiple research fields discussing their science and the process of setting up a lab 👉
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