Finally, published @JExpMed after a decade of work. Through multidisciplinary approaches, we found that components of #cigarrete & #vaping smoke (CS) modulate #MR1- #MAIT cells axis in the lung with a major implication for COPD, the third leading cause of death worldwide See 🧵

The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites @JExpMed @DrNGPhD @Jamie_Rossjohn @WaelAwadMoh @MonashUni https://t.co/2WwERKtkTC

.@Jamie_Rossjohn and @WaelAwadMoh group show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation https://t.co/jPx2HwKZlU

Mitochondria produce nucleobase ligands for T cells. Our recent paper was published today in PNAS. @Jamie_Rossjohn @Jamie_Rossjohn Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells https://t.co/UpYbAeBgYX

Our recent review on MR1/MAIT axis Molecular Insights Into MR1‐Mediated T Cell Immunity: Lessons Learned and Unanswered Questions https://t.co/JfRrHvmsBC @Jamie_Rossjohn @Jamie_Rossjohn @Monash_FMNHS

Commentary @Cancer_Cell @Schumacher_lab Learning the language of T cell receptors through large-scale screening https://t.co/9wulXGsSOm

🔓Now on Peeref: Cigarette smoke components modulate the MR1–MAIT axis 🔗: https://t.co/Gdqw1GYl8l 👁️: Altmetric: 314 @WaelAwadMoh @MayallJemma @HansbroResearch @Jamie_Rossjohn @JExpMed @RockUPress

Happy to share our #MAIT lab @TsinghuaSIGS latest review on our favourite cell homing in intestinal homeostasis and inflammation! @ScienceAdvances https://t.co/ZHoyHemv5i

Happy to share our latest findings out today in @PNASNews by @C_Boulouis showing how human mucosal-associated invariant T (#MAIT) cells rapidly adapt their functional response profile to cues in the microenvironment https://t.co/gzJhaj39lY @karolinskainst @CIM_Sweden #immunology

.@WaelAwadMoh, Mayal, Xu, @HansbroResearch @Jamie_Rossjohn et al. @MonashUni show that cigarette smoke can impair MAIT cell function by diverse mechanisms, and potentially contribute to infection susceptibility and disease exacerbations. https://t.co/V3kDiSDh7f #MucosalImmunology

Cigarette smoke components harm MAIT cell function, increasing infection risk and exacerbating diseases like chronic obstructive pulmonary disease. by Awad W, Mayall JR (...) Rossjohn J et 22 al. in J Exp Med https://t.co/fP2Bn1dqMZ #MedX #MedResearch

Cigarette smoke components modulate the MR1–MAIT axis, say Wael Awad (@WaelAwadMoh), Jemma Mayall, Weijun Xu, Jamie Rossjohn (@Jamie_Rossjohn) and colleagues @MonashUni: https://t.co/xJU3mgA79L #COPD

Cigarette Smoke Impairs Lung Immune Cells, Elevates Infection Risk https://t.co/DwVIwdg1Vz via @karmactivealive

How Cigarette Smoke Cripples Key Lung Defenders

Cigarette smoke alters immune cell function in the lungs https://t.co/wKs1DnfiWI

Have you been thinking about trying vapes or e-cigarettes? Think again! Most e-cigarettes contain nicotine and other harmful substances. Some products claiming to be nicotine-free have been found to contain nicotine. Nicotine is highly addictive and has damaging effects on the

#PressRelease 📰 Australian researchers have discovered that multiple chemicals found in cigarette smoke & e-cigarettes alter the function of a key type of immune cell found in the lungs. In our News Release: https://t.co/SJhpF1m93t Original paper in JEM: https://t.co/aZ0AtSI8OW

.@WaelAwadMoh, Mayal, Xu, @HansbroResearch @Jamie_Rossjohn et al. @MonashUni show that cigarette smoke contains a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mechanisms. https://t.co/p34qgrGLcy

Original paper 👇👇 https://t.co/55ffqJYfwG

My interview with the Australian Researchers find clue to how smoke causes disease https://t.co/xCNGpbEFIN via @australian

Cigarette smoke chemicals bind MR1 and modulate MAIT cell function in the lung through diverse mechanisms, impacting their ability to respond to respiratory infections and potentially contributing to disease @JExpMed @RossjohnLab @MayallJemma @WaelAwadMoh https://t.co/Vqn5e6tlU8