Manuel Carminati
@_M_Carminati
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Postdoc at EPFL Lausanne
Lausanne, CH.
Joined September 2021
Our work on Pol II dephosphorylation and its connection to transcription regulation and mRNA 3' end processing by the Cleavage and Polyadenylation Factor (CPF) is now out in @MolecularCell!.
Online Now: A direct interaction between CPF and RNA Pol II links RNA 3′ end processing to transcription
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RT @palconh: Our latest work on FANCD2-FANCI (D2-I), a complex that helps resolve DNA crosslinks and replication stress, is out!. https://t….
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RT @LabThoma: Check out our latest review on Pioneer Transcription Factors (TFs) by @_M_Carminati, Luca Vecchia, and @lisastoos_ in Current….
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RT @edeon: “cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers.” Amazing story by @matthieu….
nature.com
Nature Structural & Molecular Biology - Here, the authors show that the canonical BRG/BRM-associated factor (SWI/SNF) chromatin remodeler generates subnucleosomes containing...
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RT @LucasFarnung: New preprint! 🧬🖥️ With the @FrogWalterLab, we created a predictome of nucleosome acidic patch binders using AlphaFold. Ou….
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RT @emateobonmati: I am thrilled beyond words to share with you all that our work, previously posted as @biorxivpreprint, is now out in @Mo….
cell.com
Mateo-Bonmatí et al. report on how transcription termination influences local chromatin environment. They describe an Arabidopsis CPF-like phosphatase module containing APRF1, a homolog of Swd2/WDR...
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RT @WojtekGalej: I am delighted to share our latest paper on the Integrator complex assembly and association with transcription factors. Gr….
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RT @palconh: Join us in this adventure in beautiful Aarhus! PhD and postdoc positions available! If you're passionate about DNA repair and….
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RT @LucasFarnung: Very exciting! The future is bright but the scientific community needs access to the model to run large scale efforts.
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RT @isaac_fianu: Excited to share our work showing how the Integrator complex terminates RNA polymerase II (Pol II) transcription i.e. remo….
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RT @gallini_sara: Thrilled to announce the Gallini lab ( will open the door this October @epflSV. Excited to start….
gallinilab.com
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RT @CarolineDeanLab: COOLAIR and PRC2 function in parallel to silence FLC during vernalization - out now! 🌱❄️Great effort by all the author….
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RT @mpgpresident: Comparison of four transcription elongation factors reveals conserved regulatory mechanisms. New review by @YingChen_P….
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RT @Eileen_Furlong: By making small genetic deletions that remove the loop anchor on one end, we show that it breaks the loops and impacts….
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RT @MapelliMarina: We are hiring!! 📢 A Predoc position is available in the lab to bridge toward Ph.D. fellowships by Oct. 2024. All at the….
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The dimer could be involved in polymerase recycling between multiple rounds of transcription, and/or in gene looping.
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We envision that this could be the allosteric change postulated by the ‘allosteric model’ of transcription termination, where dimerization would turn Pol II into a termination competent enzyme, incompatible with elongation factors.
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Together, we propose that after cleavage and polyadenylation of the mRNA, CPF dephosphorylates Pol II and triggers its dimerization.
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Juan quantified the accumulation of Pol II beyond the TES as a ‘Retention Index’, and found that impairment of Pol II dimerization affected 70.5% of the genes being analyzed.
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