Aishwarya Prakash
@_AishPrakash
Followers
216
Following
944
Media
2
Statuses
83
PhD scholar @JNCASR trying to understand the origin of blood stem cells in mammals| Hematopoiesis, Mitochondria, Embryos | Zoologist from @hrcduofficial |
Bengaluru, India
Joined June 2023
.@jncasr researchers led by Dr. Maneesha Inamdar show that the mitochondrial protein Asrij/OCIAD1, a conserved regulator of hematopoietic homeostasis, contributes to HSC heterogeneity. 👉 https://t.co/DFuB6P10Fa
0
1
3
Happy to share our latest work in Experimental Hematology @ISEHSociety! We show that Asrij, a mitochondrial protein tunes hematopoietic stem cell fate, uncovering a new layer of blood stem cell diversity! 🩸 @InamdarManeesha
@jncasr @DBT_inStem
https://t.co/l60nyyxDUQ
7
5
37
Delighted to share that our work is published in @FrontNeurosci! 😁 We show that Asrij/OCIAD1 facilitates microglial immune responses and neuroinflammation during aging in mice. 🧠🔥 https://t.co/nE8sqxvPMT
@InamdarManeesha @govindaraju_tgr @MADHUR1022 @DBT_inStem @jncasr
frontiersin.org
Aging is characterized by chronic low-grade neuroinflammation, which increases the risk of neurodegenerative disorders. Neuroinflammation, driven by the acti...
4
6
21
It was an absolute pleasure to attend the #EMBO-LD Workshop at Girona, Spain from 21-26 Sept. Thrilled to share that I got the EMBO travel grant and the best poster award! Grateful to the organizers @MariaBohnert
@BiancaSchrul and Robin for the wonderful meeting & the venue! 😍
5
3
15
.@_AishPrakash and Dr. @InamdarManeesha show that during the endothelial-to-hematopoietic transition in the mouse embryo, dynamic changes in mitochondrial activity drive the production of hematopoietic stem and progenitor cells with differing potencies. https://t.co/JSytGZVIrL
0
7
21
Mitochondrial-activity-driven hematopoietic stem cell fate and lineage choice is first established in the aorta-gonad-mesonephros
cell.com
Prakash and Inamdar show that mitochondrial remodeling during the endothelial-to-hematopoietic transition (EHT) drives hematopoietic stem and progenitor cell (HSPC) formation. Differential mitochon...
1
11
38
Excited to share that a major part of my PhD work is out now in @CellReports!! We show that mitochondria shape blood stem cell formation and function during embryogenesis, setting the stage for healthy blood production throughout life. @InamdarManeesha
https://t.co/hIVnY9LsB1
5
5
44
Bend it like Bendless!! We are on the Rxiv @biorxivpreprint this month with our new story on the role of K63 ubiquitination in regulating signalling during hematopoiesis! Congrats team 👏🎉 Wish us luck :) @biopatrika @VoicesofIndAcad
https://t.co/Pdt3OU3WPL
biorxiv.org
Ubiquitination is a reversible modification whose traditional role has been associated with K48-linked poly-ubiquitination involved in proteasomal degradation. However, the role of K63-linked...
4
13
51
Now out in the July 10th issue of @CellCellPress LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs: Cell
1
20
108
Officially Dr. Prathamesh Dongre! 🎓✨ Thrilled to share that I have completed my PhD in Cellular and Molecular Biology from @jncasr. Huge thanks to my family, friends, and lab members for unwavering support! 🧪 🔬 Onto the next one! ❤️
6
2
44
Online now: Eomes directs the formation of spatially and functionally diverse extraembryonic hematovascular tissues
cell.com
Theeuwes, Harland, et al. show that an ESC-derived differentiation system mimics the formation of extraembryonic mesodermal tissues, including the yolk sac and allantois. Using this system alongside...
0
4
21
Happy to share our work led by @Kishalay_ish & Rohit where we show how localized & systemic genetic modulation of cellular ageing can impact organ homeostasis. Accepted version out now! @Co_Biologists
https://t.co/Smt8SwwChm
@biopatrika @VoicesofIndAcad
21
14
127
Delighted to share our recent study now out @embojournal; https://t.co/hHc3s2elj5. We characterized the hematopoietic niche in adult spleen, a lesser known host for hematopoietic stem cells.
embopress.org
imageimageThe spleen contains a rare population of hematopoietic stem cells (HSCs), but their homeostatic niche and functional regulation remain unclear. This study applies spatial proximity imaging...
28
14
92
It brings us great joy to share that our PhD student, Mr. Yash Acharya, has been selected for the prestigious ASM Future Leaders Mentorship Fellowship (FLMP) by @ASMicrobiology Congratulations @yash_amr
@NCU_JNCASR @jncasr
#ASM #FLMP #AMR
9
4
54
Excited to share our latest publication in @eLife: Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development https://t.co/2PFv2S6fgR Huge thanks to all the amazing co-authors @InamdarManeesha @PreetiJ89839688 and Ronak 🙂
elifesciences.org
The precise integration of endothelial TGFβ signaling and microtubule stability directs cardiovascular development.
5
10
28
How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. https://t.co/SUx8ZninUo
embopress.org
imageimageHow alterations in cell metabolism translate into specific developmental gene programs remains a major question. This study shows that forcing OXPHOS metabolism reprograms mouse embryonic...
2
13
38
🚨 New review out! 🚨 With my amazing PhD student @lydia_pouncey we dive into how the chick embryo has helped shape our understanding of developmental haematopoiesis and the technologies to tackle fundamental questions🩸🧬 Read it here 👇 🔗 https://t.co/88iVWGjinc
0
9
20
Excited to share my co-first author paper from Sunil Laxman's lab, now out in PNAS @PNASNews on mitochondrial activity independent regulation of mito-morphology via ROS. Great working with Gaurav, Aayushee & @a_swagata
#Mitochondria #Metabolism #Redox
pnas.org
Mitochondria are dynamic organelles that constantly change morphology. What controls mitochondrial morphology however remains unresolved. Using act...
6
22
128
1. My postdoctoral work on the non-canonical role of an autophagy-related protein at the spindle pole body (SPB) is now out in @PLOSBiology ( https://t.co/kEp4VoXCKg).
journals.plos.org
Autophagy-related proteins have roles in several cellular processes, but their function in genome stability remains unclear. Here, the authors show that Atg11 has an essential non-canonical function...
15
12
59
Exciting progress in Alzheimer’s research! 🧠 Prof. Maneesha Inamdar’s lab at BRIC-inStem is advancing studies on Asrij/OCIAD1 to reduce neuroinflammation and improve brain health. Congratulation! @DBTIndia @DBT_inStem
0
3
15