Alma Zernecke
@ZerneckeLab
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135 Forschende aus der ganzen Welt folgten der Einladung aus Würzburg und trafen sich im Kloster Banz, um sich über die aufstrebende Disziplin #Kardioimmunologie auszutauschen. Details gibt es hier ➡️ https://t.co/oc9hNRx5In
@ImmunoCardioLab @sfb1525 @DZHI_Wuerzburg @medeinsUKW
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A new piece of translational bioimaging with my great collaborator Erik Henke. @HeinzeLab is excited!
nature.com
Nature Communications - Assessing tumour microenvironment-targeted drug candidates remains challenging. Here, the authors develop a comprehensive screening platform that allows for monitoring,...
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Proud to share the second chapter of our joint work on TREM2 - this time in atherosclerosis led by Marie Piollet and @FloPorsch in this fantastic collaboration with the labs of @ClementCochain and @ZerneckeLab.
Research| Piollet, Porsch, et al. report that the myeloid receptor #TREM2 limits necrotic core formation in #atherosclerosis and controls key atherosclerosis-related functions of macrophages, such as efferocytosis, lipid uptake, and foam cell survival. 👉 https://t.co/gDxeDnYZZz
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Integrated single-cell analysis-based classification of #vascular mononuclear phagocytes in mouse & human #atherosclerosis including relevance of study models & refined nomenclature Discover more 👉 https://t.co/re9lheDDTG
@ESC_Journals @escardio #CardiovascularResearch
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Excited to share our new paper on the surprising role of complement factor H (CFH) in atherosclerosis published in @ImmunityCP today. In the study led by Máté G. Kiss and Nikolina Papac-Miličević, we identified a subset of macrophages expressing CFH.
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Numerous participants at the two-day symposium of the @EKFStiftung clinician scientist program #TWINSIGHT at the @Uniklinikum_Wue discuss aspects of systems immunology and high throughput technology. #ICSC_Wue
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Breaking ... the macrophage code. Our editorial on the excellent Zernecke-Cochain human-mouse single cell data integration! @ZerneckeLab @ClementCochain @LabMonaco @KirOxford @CVR_TomaszGuzik @ESC_Journals #AtheroVBfanatics
academic.oup.com
Modelling human atherosclerosis is challenging. Current murine models of atherosclerosis are monofactorial hyperlipidaemia-based models that are considered
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Our freshly printed Clinical Outlook in Nature Reviews in Cardiology on the potential use of scRNAseq for personalized CVD risk prediction. Great times ahead of us! https://t.co/KQ6QhnTvf1
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Am 29./30. Juni 23 wird Würzburg wieder für alle klinisch & wissenschaftlich Tätigen mit Fokus auf immunologischen Prozessen & Therapien zum place to be. Else Kröner-Forschungskolleg TWINSIGHT lädt zum Translational Immunology – From Target to Therapy VIII https://t.co/MSOKniKMew
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📢 We are announcing our Summer School 2023 (July 5-7): Cardio-immune interfaces! ❤️🩹 Please register (until May 1) here: https://t.co/9bojMXL921 We are looking forward to meet you all! 😍
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We also integrated data from 11 patients and performed cross-species data integration showing conserved features of macrophage and dendritic cell populations in atherosclerosis in mice and humans, important for future experimental investigations and their clinical translation. 4/
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Also, distinct populations of dendritic cells were detected. Based on these findings, we propose an updated scRNA-seq data based classification of mouse aortic mononuclear phagocytes in mouse atherosclerosis. 3/
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We integrated data from healthy and atherosclerotic mouse aortas, and identified subpopulations within previously described resident, inflammatory, and Trem2 macrophages. We also identified transcriptomic features distinguishing intimal resident MacAIR from Trem2 macrophages. 2/
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Happy to share our new study on scRNA-seq analysis of mononuclear phagocytes in mouse and human atherosclerosis, now out in Cardiovascular Research ( https://t.co/17aVbmS4ja), led by @ClementCochain in collaboration with @WeinbergerTobi, @AE_Saliba, and others. 1/
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3 days of Cardio-Immune crosstalk are almost over. Great talks today of Burkhard Ludewig and Jürgen Schrader! Thanks to everyone for joining and enjoying! 👏🏻 See you next year! ❤️ @medeinsUKW @DZHI_Wuerzburg @Helmholtz_HIRI @RVZ_Wuerzburg @KantonsspitalSG @UniklinikDUS
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Translational Immunology – From Target to Therapy VII Das int. Symposium des Else Kröner #Forschungskollegs #TWINSIGHT mit Schwerpunkt Systemimmunologie und Hochdurchsatztechnologien findet am 14./15. Juli im Juliusspital/Würzburg statt. @Uniklinikum_Wue
https://t.co/JAUukir15N
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@InstCardReg_FFM @WesleyAbplanalp @AndreasZeiher @YoungDZHK @DimmelerLab Good to know 💡: From now on, the Science on Friday webinars are also open to non-DZHK members. If you want to be added to our invitation list, please send an email to info@dzhk.de.
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Forschungskolleg TWINSIGHT @izkf_wuerzburg mit Schwerpunkt Systemimmunologie und Hochdurchsatztechnologien lädt am 14./15. Juli 2022 alle Interessierten zum internationalen Else Kröner-Symposium im Würzburger Juliusspital ein. https://t.co/9v6hQWobp1
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Happy to share our recent review. Hope that the links to publicly avalaible data from cardiovascular tissues, disease models and human samples may be helpful for your own research! #singlecell #CVdisease
Great new review published today in European Heart Journal @escardio on how to use single-cell technologies to decipher cardiovascular diseases by @WesleyAbplanalp @StefanieDimmel1 and @NR_Tucker Check it out --> https://t.co/bl3v7dUyqT
#singlecell #CVdisease #science
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Outstanding Cardio-immunology meeting, excellent program!
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