Tobias Weinberger, MD
@WeinbergerTobi
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cardiologist interested in innate immunity especially resident macrophages
Paris, Frankreich
Joined December 2018
And 2/ thanks to the @Fondation_BS for the Impulscience award to make our dream project possible! Congrats to all my fellow laureates and warmest thanks to the great team at la fondation and @EloScicomm ! What an amazing ceremony last night!
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🚨 Kritik aus der #Herzmedizin: Der neue GOÄ-Entwurf stuft lebensrettende Eingriffe wie Stentimplantationen um bis zu 60 % ab. Folgen: Mögliche Kostenunterdeckung bei #Herzinfarkt-Behandlungen. Mehr in Presseinfo: https://t.co/IY1Ms3v8nU
#DGK #Herzmedizinde #DGKPresse
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@ImmunoPasteur @CPridans @mjoppich @waskowlab @GulcePercin @DenaEsfandyari @AndrsHidalgo16 @TodicaAndrei And of course @EGP_Mac_Lab !
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And of course a big thank you for funding this work! @escardio
@dzhk_germany
@CRC_TRR332
@CRC1123_Athero
@SFB914
@LMU_Uniklinikum
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A big thank you to everyone who contributed to this work! @ImmunoPasteur
@CPridans
@mjoppich
@waskowlab
@GulcePercin
@DenaEsfandyari
@AndrsHidalgo16
@TodicaAndrei And everyone not in twitter (yet…:-)
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6/Taken together we show that resident macrophage play an important role in cardiac remodeling and orchestrate the immune response while recruited macrophages determine infarct size.
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5/Depletion of both, resident and recruited macrophages by CSF1R inhibition led to an absence of macrophages throughout the whole heart including the infarcted area. This had a detrimental effect on cardiac function and infarct size.
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4/While FIRE 🔥 mice showed adverse cardiac remodelling over time we observed no difference in LV-function or infarct size in FIRE 🔥 mice. In line with this the amount of macrophages in the scar area was unchanged in FIRE 🔥 mice.
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3/Absence of embryo-derived macrophages was associated with an impaired crosstalk of immune cells and a proinflammatory phenotype of different subsets of leukocytes e.g. neutrophils.
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2/ScSeq transcriptomics of cardiac leukocytes in 🔥 FIRE mice revealed that the remaining macrophage population differs from control 🐭with a decrease of homeostatic ❤️🩹and antigen-presenting macrophages. Also the phagocytic property of the macrophage population was reduced.
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1/Using different fatemapping approaches we could show that embryo-derived macrophages represent the major macrophage population in the heart. In FIRE 🔥 mice this population is completely absent.
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Very excited to share our latest research on the role of cardiac macrophages in myocardial infarction https://t.co/CPAStSoE0B
@eLife
elifesciences.org
In cardiac ischemia/reperfusion injury, resident macrophages orchestrate the immune response and positively influence postinfarct remodeling, whereas recruited macrophages determine infarct size.
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Do you want to confess with myocardial macrophage monks? Come to this conference in a Bavarian monastery! All religions welcome. 👇 II. Cardioimmunology congress from June 26th, 2024 to June 28th, 2024 ⛪️🔥❤️🔥⛪️ https://t.co/8fuEdThfzu
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Tomorrow #PreprintHub2 w/ Donald Okoye @OGDonaldMSTP & Akerke Altaikyzy @MDC_Berlin will discuss how resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia @WeinbergerTobi @dzhk_germany ❤️🩹🩹👇
biorxiv.org
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of...
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Exciting PhD project! Short-notice opportunity for a fascinating journey at the crossroads of metabolism, developmental biology and immunity in a great team. Apply at https://t.co/zNW1heUEhU
@Cardio_LMU @LMU_Muenchen @LMU_Uniklinikum @YoungDZHK @dzhk_germany
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Health Consequences of Thymus Removal in Adults | NEJM
nejm.org
The function of the thymus in human adults is unclear, and routine removal of the thymus is performed in a variety of surgical procedures. We hypothesized that the adult thymus is needed to sustain...
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The first meeting was one of the best conferences I have been to! Looking forward to the next Cardioimmunology Symposium in Würzburg!
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Our new paper @JExpMed
https://t.co/YA8lmvr3ck Clodronate liposomes deplete mononuclear phagocytes (MoPh) and strongly inhibit arthritis mouse models. We found it weird that none of the genetic models of MoPh deficiency recapitulated CloLip treatment and learned that 1/2
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Please join us tomorrow for an exciting talk. "Organization of the innate immune system" Not to be missed
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New on twitter, thanks for promoting our work on your cover! @LA_NatRes @Cardio_LMU @LMU_Uniklinikum @dzhk_germany #AFib #EPeeps
February is live and the Table of Contents is here: https://t.co/puAKOewJLh On the cover: A practical guide to setting up pig models for cardiovascular catheterization, electrophysiological assessment and heart disease research https://t.co/JAY6XitIyN
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