Ever wondered why nucleoli often have such complex shapes—despite behaving like liquids? If liquids tend to form spheres, why don’t nucleoli? What shapes them? We explore this in our latest preprint @embl. Great work led by Daja Schichler & @YH_YukiBio! https://t.co/Gtu72hUkOc

All this would not have been possible without all the help from our great team: @CuylenLab, Daja, @AHA_Alberto, Letitia, Mariam, Faba (Beate), Sara!

🧩 We propose that amphiphilic Ki-67 tethers chromatin inside and outside the nucleolus, controlling its irregular shape.

Just disrupting chromatin is enough to round the nucleolus, highlighting chromatin’s mechanical role in shaping it.

Ki-67 uses two distinct domains—one for chromatin, one for the nucleolus—to localise right at their interface.

Conversely, over-expressing Ki-67 causes the nucleolus to become more irregular and draws in excess chromatin.

Depleting Ki-67 makes the nucleolus rounder and, unexpectedly, reduces chromatin enrichment within its interior.

Ki-67 isn’t just a proliferation marker and mitotic chromosome surfactant. Our high-throughput imaging screen reveals it’s key to nucleolar shape.

Excited to share our new preprint on @biorxivpreprint from our great team @EMBL! https://t.co/JaeFubrQWd If the nucleolus is liquid-like, why does it often appear irregularly shaped in proliferating mammalian cells? What controls the nucleolar shape? #PhaseSeparation #Nucleolus

日本政府が本当にばら撒くべき人たちは、研究者たちである。良い研究に関する議論は必要やけど、言葉選ばずに言うと、とにかくばら撒け。

Interested in rapid imaging-based screening or sorting of rare cell populations? A new era of cell sorting has begun! Check out our latest review in @TrendCellBio on novel flow cytometers with imaging capabilities. Congrats, @terrabyte21! https://t.co/51R7BEXGXm

Online Now: A liquid-like coat mediates chromosome clustering during mitotic exit https://t.co/nPNlTwRKAX

Our latest paper is out today @MolecularCell! Led by a @AHA_Alberto and with important contributions from @SaricLab & @EllenbergLab! We show how chromosomes shift from being repulsive to becoming attractive during mitosis. Read all about it here: https://t.co/nXRWXkgJRc

Our new preprint describing how Ki-67 switches from a chromosome surfactant to a chromosome glue is online! Fantastic work lead by @AHA_Alberto @embl. Many thanks to our great collaborators from @SaricLab and @EllenbergLab. https://t.co/7wFuowAfTJ

I am extremely happy to share my @biorxivpreprint of my PhD work @EMBL! 🔬👨🏽‍🎓 A liquid-like coat mediates chromosome clustering during mitotic exit https://t.co/FjukpI7XBu

Exciting new work on genetically encoded multimeric tags for subcellular protein localization in cryo-EM from the Cuylen-Haering & Mahamid labs. https://t.co/3sDWPlYpkR

Great imaging Post Doc available!

Excited to share our new paper @ScienceAdvances: https://t.co/0LVVQy2dbF Dual-color imaging of two neighbor nucleosomes reveals that nucleosomes in euchromatin form condensed domains with ~150 nm diameter. Nucleosomes locally fluctuate in the condensed domain like a liquid. 1/

#IBSevents : Friday 27/01 at 11am, seminar @IBS_Grenoble by Hermann Fung (@embl Heidelberg) entitled "Cryo-correlative strategies and genetically encoded multimeric particle tags for protein localisation in cellular cryo-ET": https://t.co/Vl2KMBtrMS

We have 20 labs taking part in the @viennabiocenter Summer School 2023 call. @ShotaroOtsuka (Max Perutz Labs) is offering a position for this exciting program! Check out our website: https://t.co/kVA4rRnbET @IMPvienna @IMBA_Vienna @gmivienna @MaxPerutzLabs @CeMM_News