Xingyu Liu 刘星宇
@Xingyuu_Liu
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Joint postdoc between the Yu and Cravatt lab @Scrippsresearch; PhD in LCSO @EPFL
Lausanne, Switzerland
Joined February 2020
The review of @Xingyuu_Liu on the group work on peptide/protein functionalization and macrocyclization published at Acc. Chem. Res. https://t.co/L2xPd99SON What next? With all these nice tools developed, we are eager to collaborate with chemical biologists for applications!
pubs.acs.org
ConspectusAlkynes are one of the most fundamental functional groups in organic synthesis due to the versatile chemistry of the triple bond, their unique rigid structure, and their use in bioconjuga...
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The work of Xingyu Liu @Xingyuu_Liu in collaboration with Wei Cai in Beat Fierz @Beatfierz group @LCBM_EPFL and Anne-Sophie Chauvin on peptide-cyanoarenes used as photocatalysts is now accepted in @angew_chem ! https://t.co/ej5I529HuE
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Not So Bioorthogonal Chemistry | Journal of the American Chemical Society @maxplanckpress @DominikSchauen1 @WeilTanja @mpi_polymer #JACSPerspective
pubs.acs.org
The advent of bioorthogonal chemistry has transformed scientific research, offering a powerful tool for selective and noninvasive labeling of (bio)molecules within complex biological environments....
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Big thanks to Wei @WeiCaiWell for help with western blotting and cell experiments, Beat @Beatfierz for insightful discussions on biological applications, and Anne-Sophie for photophysical property measurements!
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Additionally, the high excited-state energy of the Cz(I)PN core enabled aryl azide excitation. We designed conjugates with functional peptides serving as ligands for target-specific labeling of integrin αvβ3 in live cells. 5/5
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To demonstrate their utility, we applied these conjugates in photo-mediated transformations on biomolecules: 1. Peptide C-terminal decarboxylative alkynylation 2. Thiol-ene reactions on cysteine residues in aqueous media. 4/5
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Both methods produce peptide-dye conjugates with broad redox potential, strong delayed fluorescence, and high excited-state energy, making them highly promising photocatalysts for biological applications. 3/5
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1.Photo-mediated peptide C-terminal decarboxylative substitution: This approach links peptides to Cz(I)PN, forming CzBn-peptide conjugates. 2.Selective SNAr reaction with Cys residues on CzFIPN precursor. 2/5
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Excited to share the last part of my PhD work! Carbazole-based organic dyes like Cz(I)PN are one of the most privileged photocatalysts due to their high quantum yield and long-lived delayed fluorescence. We developed two efficient methods to incorporate peptides into them. 🧵 1/5
Have a look @ChemRxiv on a new class of peptide-cyanobenzene dye photocatalysts developed by @Xingyuu_Liu in collaboration with Dr. Anne Sophie Chauvin and Wei Cai/ @Beatfierz @LCBM_EPFL - https://t.co/wljBQhGnvF
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Congrats to Xingyu @Xingyuu_Liu for wining a runner-up oral presentation award at the Peptide Therapeutics Forum 2024 of @SwissChemistry with the support of @HelvChimActa (photo from @SwissChemistry )
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I am so proud of being a member in LCSO for the past four years, surrounded by a group of truly amazing people who have inspired and supported me all the way !!
Congratulations to Xingyu Liu @Xingyuu_Liu for becoming the 27th doctor of the group! 🎓 We wish you all the best for the future!
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Hypervalent Iodine Amino Acid Building Blocks for Bioorthogonal Peptide Macrocyclization (Jerome Waser and co-workers) @LcsoLab @EPFL_CHEM_Tweet @Xingyuu_Liu #openaccess #bioorthogonalchemistry
onlinelibrary.wiley.com
The development of non-proteogenic amino acids (NPAAs) containing hypervalent iodine reagents -ethynylbenziodoxoles (EBxs)- is described. These NPAAs were compatible with both solid phase peptide...
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Happy to share my PhD work on peptide-hypervalent iodine conjugates at the 18th Chinese International Peptide Symposium (night views taken from the Hong Kong Observation Wheel) !! #CPS2024
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Congratulations to the winners of the Best Poster Awards during the @SNE_ChemBio retreat! 🏆 Xingyu Liu (@Xingyuu_Liu, @LcsoLab) 🏆 Terézia Dorčáková (@ZampieriLab) 🏆 Henriette Lämmermann (@RiveraChemLab) Sponsored by @spirochrome, Milian Dutscher group & Witec 🙌
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From one orthogonal EBx handle, we are able to form structurally diverse cyclic peptides with various native residues (Cys, Lys and Trp). We are happy to send the amino acid on demand!
Xingyu @Xingyuu_Liu with the help of Olha and Adriana @adriana_faraone developed new non-natural amino acids containing a EBx reagent for solid and solution phase peptide synthesis, leading to new ways towards macrocycles, now accepted @angew_chem
https://t.co/ZZjDZjktFV
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.@CarolynBertozzi is a scientific celebrity. But as a young chemist, Bertozzi struggled to make her way into the field. C&EN follows how the culture of chemistry has changed throughout Bertozzi’s career—and how she, in turn, has changed the culture. https://t.co/6Bg5GGsHQT
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Finally I read this viewpoint in @ACSMedChemLett. I do not disagree that successfully crafting a total synthesis is a good medicinal chemisty training ground, but how the over-competitive culture in total synthesis groups has stiffled chemistry innovation can't be ignored. (1/x)
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Excited to have played a small role in this massive work of @ManuelLMerz in the pursuit for orally available cyclic peptides. Now out in @nchembio #openaccess
https://t.co/1kNoBDMlIO
nature.com
Nature Chemical Biology - Cyclic peptides show promise for modulating difficult disease targets; however, they often cannot be administered orally. The authors developed a method to synthesize and...
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Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization | Journal of the American Chemical Society @LCSOLab
@EPFL_Chem_tweet @TotalSyntheses #Fluorescent #Cyclic #Peptides #Au #Macrocyclization
pubs.acs.org
Rapid and efficient cyclization methods that form structurally novel peptidic macrocycles are of high importance for medicinal chemistry. Herein, we report the first gold(I)-catalyzed macrocyclizat...
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