Alexander L. Nielsen
@alexanderln91
Followers
591
Following
2K
Media
105
Statuses
525
find me on the friendlier platform https://t.co/ORQTOwhQLJ
Copenhagen, Denmark
Joined January 2018
goodbye X happy science-twitter seems to have finally found peace on 🔵☁️ find me on the other side:
0
0
0
We have two fully funded PhD opportunities in medicinal chemistry and chemical biology through the EASTBIO BBSRC DTP. Deadline 17th Jan 25 More details and apply below https://t.co/v5VD1kl8DP https://t.co/isfazFDYKU
findaphd.com
PhD Project - EASTBIO-Peptide-based precision anti-infectives for prophylaxis and treatment of foodborne listeriosis at University of Edinburgh, listed on FindAPhD.com
1
15
22
Happy to share the latest preprint from my PhD studies on the discovery of de novo macrocyclic inhibitors of HDAC11. This was a great collaboration between @christianaolsen lab (@carlosmyruela, @tnhansen) and Christian Heinis lab (@alexanderln).
New preprint @ChemRxiv on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis @EPFL_CHEM_Tweet. @DankovaDaniela, @alexanderln91, @CarlosMYruela, @HanseNrby, @UCPH_health We thank @ERC_Research, @novonordiskfond, @DFF_raad for 💶 https://t.co/poyRhtpJKZ
3
3
11
The macrocycle is therefore fully validated as a potent, selective and cell-permeable probe of HDAC11. We hope that it can shed some light on HDAC11 biology of which we still understand very little. Huge thanks to all the co-authors, this project was a great collaborative effort.
0
3
5
Herein, we developed selective HDAC11 inhibitors using high-throughput peptide synthesis in 384-well plates, along with library formation and screening in 1536-well format. This work highlights the power of automation, miniaturization, and liquid handling robots in chemistry.🦾
0
0
1
Check out our latest preprint! A fun collaboration from my time in postdoc times in the Heinis lab 😎
New preprint @ChemRxiv on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis @EPFL_CHEM_Tweet. @DankovaDaniela, @alexanderln91, @CarlosMYruela, @HanseNrby, @UCPH_health We thank @ERC_Research, @novonordiskfond, @DFF_raad for 💶 https://t.co/poyRhtpJKZ
1
0
15
One of my last posts before migrating to 🔵☁️ But can't help but share this amazing work by my colleagues. Now out in Nature Comms! https://t.co/C5Zz0mMLBr
nature.com
Nature Communications - C-terminal α-amidated peptides are attractive therapeutic targets, but preparative methods to access amidated pharmaceuticals are limited both on lab and...
0
2
47
Exciting paper from my colleagues at @novonordisk. Just published in @nature! https://t.co/JEZgZbyyHb
nature.com
Nature - NNC2215 is an insulin conjugate that can reversibly adjust its bioactivity in response to a diabetes-relevant glucose range in vivo.
1
7
47
Very excited for this collaboration with @NinaHartrampf for which we are looking to fill a PhD position in the Hartrampf group at the University of Zürich with research visits to Novo Nordisk in Denmark! More information here:
Are you looking for a PhD position in peptide synthesis, automation, and computational analysis? 🧪 💊💻 We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: https://t.co/amkdtbVBTC ⏰ Application deadline = November 15
0
3
17
I am really excited to share our latest #sirtuin research on @biorxivpreprint! We used mechanism-based crosslinking to solve the structure of SIRT7 and its interaction with biological substrates on the nucleosome. More details to follow 🙂
Structural basis of SIRT7 nucleosome engagement and substrate specificity https://t.co/y9qJQVaMBO
#biorxiv_biophys
1
6
30
Are you looking for a PhD position in peptide synthesis, automation, and computational analysis? 🧪 💊💻 We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: https://t.co/amkdtbVBTC ⏰ Application deadline = November 15
0
42
108
It was a pleasure to host this year’s Novo Nordisk Chemist of the Future Symposium. Such a high level of talks from the invited and talented PhD students/postdocs in chemistry. Thanks for some wonderful days of science!
0
3
29
Small N-terminal macrocycle with a D-amino acid can stabilize alpha-helices. RaPID doesn't just generate new individual molecules, it can also summon up intriguing chemical motifs. Now out in JACS: https://t.co/FZUVJYWOhh
@fabian_hink
@daviddesancho
@novonordiskfond
@UCPH_health
pubs.acs.org
Interactions between proteins and α-helical peptides have been the focus of drug discovery campaigns. However, the large interfaces formed between multiple turns of an α-helix and a binding protein...
6
12
55
We are looking for a new Department Manager in Research Chemistry. 🇩🇰🧑🔬 #chemjobs
https://t.co/Yn1cjT27oY
novonordisk.com
Check out this open position at Novo Nordisk. Starting a career with us is your opportunity to improve the lives of millions of people.
0
2
15
Here is the job posting to join the Heinis lab as a PhD student in this consortium:( https://t.co/csTM4wMFFO)
#PhDposition
Very excited for this consortium!
0
1
5
Very excited for this consortium!
MC4DD: New EU consortium on drug discovery dedicated to macrocycles. 8 universities and 6 industry partner join forces to advance the science of macrocycles as drugs. More information: https://t.co/jUiqIkEzVd
0
0
10
Become our future colleague! 🇩🇰Extensive display-experience required. https://t.co/fENQpEtskW
0
1
12
Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation (Christian Heinis and co-workers) @alexanderln91 @EPFL_CHEM_tweet #openaccess
onlinelibrary.wiley.com
Macrocycles are promising for drug development due to their good binding properties and the potential to cross membranes. A synthetic strategy and chemical building blocks are developed to produce...
3
5
23
Now out in its final, edited, version. https://t.co/QWovpJ2q18
Very pleased to share one of my postdoctoral works from the Heinis lab. Now published in @angew_chem #openaccess #macrocycles
https://t.co/9Doa451TdA
1
2
40
Excited and proud to see the main work from my PhD and postdoc on the development of "GLP-1 directed NMDA receptor antagonism for obesity treatment" out in @Nature today! https://t.co/LLDn8oVbph 1/7 🧵
nature.com
Nature - Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.
8
30
171