Excited to share my work revealing that functional organization of human cortex is reflected in the spatial variability of different cell types. w/@AvramHolmes @KevinMAnder Hao-Ming Dong @SidChop @elvisha9  Prashant Emani @MarkGerstein @DanielMargulies! https://t.co/BudtvYgNCz

Latest @HolmesLab_BHI preprint! Here, integrating genetic 🧬, post-mortem, and diffusion MRI 🧠 data, @ChinERowena examines the heritability and cellular associates of late-life decline in white matter integrity. Check it out!

Excited to share this new work - especially grateful to collaborators @XihanZhang1 @KevinMAnder @nastasiayendiki !

I will give a virtual talk at MGH (Center for Precision Psychiatry Seminar Series) on our recent NBME paper to discuss cross-disease heterogeneity and overlap using AI and imaging genetics: https://t.co/t1svQp43fc. Registration link is here: https://t.co/6VB3kiHMXS

I love this sentence from a Nature paper: “Overall, all six modules exhibited distinct activity patterns along psudotime but comparable patterns across trajectories.” The take-home point: there are differences and similarities. Bravo, feels like learned a lot 😆

Scientists identify distinct brain patterns linked to mental health symptoms

New paper by Lydia Qu @laurant_lydia et. al out now in Nature @NatMentHealth 📰 Here, we show that predictive network features are distinct across internalizing and externalizing traits/behaviors. With @carrisa_cocuzza,@bttyeo,@elvisha9, and more 🌟 https://t.co/YzuoTCq4Ln

Holmes Lab newest paper from @OrchardWinnie highlighted in @nypost about the impacts of parenthood on the brain. 🤰👨‍👩‍👧🧠 Read the full paper here:

We are thrilled that Holmes lab recent paper by @XihanZhang1 et al. has been featured on the cover of @_TheTransmitter! Check out the paper here: https://t.co/nXaf11Eg5K And the article 🖇️ 🧬

Our latest out now in @BiologicalPsyc1 , a collab led by R Petrican, w/ @SidChop and C Murgatroyd looking at how physiological aging relates to psychiatric risk and brain changes in males and females: https://t.co/8xmdqEYBmt

Mapping neuropeptide signaling in the human brain | https://t.co/ciazq7op2Z Neuropeptides are among the functionally diverse signaling molecules in the brain and body. We curate an atlas of neuropeptide receptors and relate it brain function 🧩🧠⤵️

I am absolutely stoked to share our new study on multiscale neural dynamics across species and behaviour + network simulations exploring their benefits! The best lab going around! Captained by THE @jmacshine 🙌

“A simulated annealing algorithm for randomizing weighted networks” | https://t.co/z5BJ6QSlGY How do we randomize brain connectomes (and other networks) with biological edge weights? @NatComputSci ⤵️

Just published🔈 "Structurally informed models of directed brain connectivity" Read: https://t.co/8Ry7Uf4CQf We review how structural connectivity constrains directed connectivity models 🧠 Lead by @matthewdgreaves w/ @novelli_leo, @Sina_Mansour_L and @AndrewZalesky

Multimodal data from 98 individuals: neuroimaging, genetics, dendritic spine morphometry, proteomics, and gene expression; identifies 100s of proteins that explain individual differences in MRI measures @HerskowitzLab https://t.co/JW0xxRnhxT

Dec 6th 4:30-6:30 at Standard University

@AvramHolmes @KevinMAnder @SidChop @elvisha9 @MarkGerstein @DanielMargulies @AllenInstitute @bogglerapture @KonradWagstyl @YaleNeuro @WuTsaiYale @YalePsychDEI @YalePsychology @GraduateYale

@AvramHolmes @KevinMAnder @SidChop @elvisha9 @MarkGerstein @DanielMargulies @AllenInstitute @bogglerapture @KonradWagstyl Behind the scenes: I have only been in the silent meditation retreat three times in my life, but each time hearing back from the journal was during one of these retreats. Finally, this three-year project has turned into my first first-author paper. So much appreciation to amazing

@AvramHolmes @KevinMAnder @SidChop @elvisha9 @MarkGerstein @DanielMargulies @AllenInstitute 7/7 Wondering what this means for the field? Review article by @bogglerapture and @KonradWagstyl discusses how my paper adds to converging evidence for the organization of the cortex along the sensory-association axis. https://t.co/VcjW1JQiyJ

@AvramHolmes @KevinMAnder @SidChop @elvisha9 @MarkGerstein @DanielMargulies @AllenInstitute 6/7 Consistent with these patterns, functional network assignment can be predicted by cell-type abundances in post-mortem tissue. Besides unimodal somato/motor, visual, and transmodal limbic networks, ventral attention/salient network can be well-predicted. Default,

@AvramHolmes @KevinMAnder @SidChop @elvisha9 @MarkGerstein @DanielMargulies @AllenInstitute 5/7: Large-scale networks possess distinct cellular profiles, hinting at computing motifs for specialized functions. For example, dorsal attention network is enriched by layer 2/3 and layer 5 ITs, whereas ventral attention/salient network is enriched by layer 6 neurons.