Kaustubh Wagh
@WaghKaustubh
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Postdoctoral Fellow @NCIResearchCtr, @NIH. Tracker of single molecules.
Maryland, USA
Joined May 2013
🎯 The multimerization pathway of the glucocorticoid receptor
academic.oup.com
Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf
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(1/8) Excited to see our collab w. @ViraatGoel Ed Banigan @ngaboreden James Jusuf, Leonid Mirny and Gerd Blobel out in @NatureSMB
https://t.co/2Ri3nom8jt This was co-submitted with A Schooley and Job Dekker's preprint https://t.co/0Y6CmePM1Z which should also be online soon.
(1/n) From @ViraatGoel @Irate_Physicist et al. collab w @blobelgroup @leonidmirny
https://t.co/CdI7n2P31a RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry Sims reveal chromosome compaction as key regulator
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(1/2) Super excited to post our updated pre-print showing RNAPII clusters during Drosophila embyrogenesis are simply collections of polymerase molecules stably engaged at single genes and do not require higher-order assembly mechanisms. Check it out at: https://t.co/fiirHs38Gv
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The preprint of our latest research paper is out: Chromatin organization modulates cytoskeletal remodeling in T cells. Check it out!
Nuclear morphology and chromatin organization modulate T cell cytoskeletal remodeling and immune synapse formation https://t.co/ZUymtHD9Sj
#biorxiv_biophys
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Check our recent pre-print! A thorough study on chromatin organization around trans-splicing acceptor sites in trypanosomatids: https://t.co/3GudrGcpnD
@JOcampoLab, @SMATryps, @psmircich
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📢 Read our new bioRx in colab with Gordon Hager NIH @PabloFuentesP #FRecio @aguslafuent @PresmanLab @WaghKaustubh #IGoldstein et al where we found glucocorticoid receptor GR self-assembly, chromatin binding & activity is modulated by bile acids binding to a novel druggable site
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Super excited that Expansion In Situ Genome Sequencing (ExIGS) is out now in @ScienceMagazine ! Check out the paper to see what can be revealed by sequencing the genome in its native position and high-res imaging its interactions with nearby proteins. https://t.co/weVnIz7RD1
science.org
Microscopy and genomics are used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. Here, we describe expansion...
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Our latest article made the cover @NAR_Open! Read about how transcription factors guide NIPBL/MAU2 to enhancers here:
academic.oup.com
Abstract. While the cohesin complex is a key player in genome architecture, how it localizes to specific chromatin sites is not understood. Recently, we an
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Do Glucocorticoid Receptor (GR) condensates play a role in transcription? Check out our latest paper, where we explore this key question - relevant for understanding how glucocorticoids work. 🔬 https://t.co/HL4kEmNT1N
@belen_ben843 @PresmanLab @stortzmd
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Excited to share our preprint on a long-term (3yrs) follow-up study on epigenetic memory at an engineered naïve chromosome site modulated by transcription of an Oncogenic lncRNA. We show cells initiate various epigenetic silencing mechanisms to suppress a neocentromere formation.
Oncogenic lncRNA transgene transcription modulates epigenetic memory at a naive chromosomal locus. https://t.co/05Yz5qyXSm
#biorxiv_genetic
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Our pre-print is finally out in iScience! (@iScience_CP) Go check it out here 👇 https://t.co/DZsdWXOEu8
@ifibyne @iquibicen @CONICETDialoga @Exactas_UBA
cell.com
Biochemistry; Cell biology
Pre-print Alert! 🚨🚨 Do Glucocorticoid receptor (GR) condensates have a role in transcription? Check out the opera prima from PhD student @belen_ben843 at @PresmanLab and @VLeviLab
@ifibyne @iquibicen @Exactas_UBA 👇 https://t.co/RWolGeQJhk 1/7 Thread below 🧵🧵
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Our paper showing that transcription factors form a ternary complex with NIPBL and MAU2 is now published in Nucleic Acids Research: https://t.co/Xx9C0Fejkd
academic.oup.com
Abstract. While the cohesin complex is a key player in genome architecture, how it localizes to specific chromatin sites is not understood. Recently, we an
Our latest preprint is online! Read about how transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers Collaboration with @GregoryFettweis, @AlbaJimP1, Diana Stavreva, @Eva46653369, Hager and Dequiedt labs https://t.co/tJ5RSVK1wu
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Our latest preprint presents a new post-processing methodology to improve the resolution of microscopy data for when many different loci are imaged, like chromatin tracing data (I think its a cool idea):
biorxiv.org
Numerous functions hinge on the spatial dynamics of different genomic loci. Hence, microscopy techniques, such as chromatin tracing, have been developed to localize multiple loci in living and fixed...
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Glucocorticoids are powerful anti-inflammatory drugs, but with serious side effects. Here, we review how fluorescence fluctuations methods deepen our understanding of the glucocorticoid receptor's role https://t.co/3pfAkMhobv
@PresmanLab @stortzmd @aguslafuent @camioses_
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Exciting news! 🎉 After a long journey, my postdoctoral research is finally published! 🌟 While we often hear about telomere depletion with age, have you ever wondered what happens to our centromeres? 🤔 In this study, we show how centromeres weaken and ways to reactivate it !!
Online Now: Centromere inactivation during aging can be rescued in human cells https://t.co/ilkCAdYZ4v
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Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology @RamLabUW
https://t.co/E5N0JCtB8j
science.org
Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein...
m7GpppNm - VERY EXCITED to share my postdoctoral work in with @RamlabUW, now out @bioRxiv. We found that cellular RNA interacts with MAVS, the adaptor protein of the RIG-I-like receptor pathway, to promote antiviral signaling. "🧵": https://t.co/Ik5yYQsLaP
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🎯 On the importance of collaborating with awesome scientists but most importantly amazing people who honor teamwork @PabloFuentesP G.Hager @AlirezaMashaghi @PresmanLab @PalomaPerez_IBV @Andrea_AlegreM @AlbaJimP1 @aguslafuent @GregoryFettweis @WaghKaustubh @VSheikhhasani ✨️
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🎯 Our new laboratory preprint is out! Awesome collaboration with the labs @PabloFuentesP Gordon Hager, Juan F. Recio @PalomaPerez_IBV @PresmanLab and lead by incredibly talented @Andrea_AlegreM @AlbaJimP1 @aguslafuent
@montseabella7 Tom Johnson 🎉🥳✨️ https://t.co/aOkIh4W5wg
biorxiv.org
The glucocorticoid receptor (GR) is a leading drug target due to its anti-inflammatory and immunosuppressive roles. The functional oligomeric conformation of full-length GR (FL-GR), which is key for...
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