Vikram Shende
@VikShende
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Assistant Prof. @occidental by way of @moorelabsio and @davidhsumich. Enjoyer of dark beer, podcasts, and natural product biosynthesis. he/him/his
La Jolla, CA
Joined August 2013
In addition to being a proud member of @moorelabsio, my time at @Scripps_Ocean allowed me to collaborate with natural products legends. Thrilled to see this in print, and huge congratulations to @holland_dch who did all the heavy lifting. https://t.co/knmlntEg38
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I hope you’ll watch this short video from @BradMoore_SIO on the valuable impact federal funding has on basic science research that leads to the discovery of new, life-saving medicines.
🔬 At @ucsandiego, scientists like Brad Moore–Distinguished Professor at Scripps Oceanography and @ucsdpharmacy–are leading the charge to source and develop compounds from nature that are being used to develop the next generation of medicines. 🧵⬇️
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Huge congratulations to Casandra Hurtado in @davidhsumich's research group for finishing this really incredible project! https://t.co/V8hZXcaCz3
pubs.acs.org
The privileged fused-ring structure comprising the bicyclo[2.2.2]diazaoctane (BDO) core is prevalent in diketopiperazine (DKP) natural products that exhibit potent and diverse biological activities....
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I learned so much watching @sanjoyadak90 work on this project during our postdocs, and a huge congrats to him and @BradMoore_SIO for getting this out in print! Absolutely worth a read!
Single-Enzyme Conversion of Tryptophan to Skatole and Cyanide Expands the Mechanistic Competence of Diiron Oxidases by @sanjoyadak90, Logan Calderone, @august_krueger, Maria-Eirini Pandelia, @BradMoore_SIO @moorelabsio @Scripps_Ocean in @J_A_C_S
https://t.co/PtA6UVcbik
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Congrats @qingydan1991!
Excited to share our latest in Nature Catalysis led by @qingydan1991! We developed a modular polyketide-based platform for biosynthesizing diols, amino alcohols & hydroxy acids—key industrial chemicals used in solvents, polymers & pharma. Read more (1/3): https://t.co/09Q1Q3boWU
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Standing-room only as Professor Bradley Moore (@BradMoore_SIO) accepts @UCSanDiego’s prestigious Distinguished Research Award. The award is a sign of respect from his peers for his groundbreaking research mining the ocean for new medicines.
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We always knew @moorelabsio alum @kdbauman_ was going to make it big, and huge congrats to her and the team for this really excellent work!
New work from @mfgrp lab! It was such an honor to work with the insanely talented @DjenetBousbaine and so fun to see it all come together here!
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We're looking for a new Assistant Professor in Marine Natural Products/Marine Biotechnology @Scripps_Ocean. Come join us -
apol-recruit.ucsd.edu
University of California, San Diego is hiring. Apply now!
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I had the great fortune of overlapping with the great @JeanieTan10 while she was an undergraduate researcher with @davidhsumich and it’s wonderful to see her continue to thrive! Congratulations Jeanie!
New work from our lab: @JeanieTan10 leads a partnership with middle school students from the Boys & Girls Club Chicago @BGCChi to discover new bioactive natural products. High-end NP discovery and outreach can coexist! https://t.co/9pUanuLONF
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Need to get this laminated and glued to my hood and bench immediately.
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A single diiron #enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile by @sanjoyadak90, @naike_y, Calderone, Duan, Lubeck, Schäfer, @AprilLukowski, @houk1000, Pandelia, @Drennan_Lab, & @BradMoore_SIO @moorelabsio in @NatureChemistry
https://t.co/pOXkcegAIv
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Never underestimate a diiron enzyme. Congrats @sanjoyadak90 for bringing the nitrile synthase AetD to life with @Drennan_lab, Maria-Eirini Pandelia, and Ken Houk labs. Published today @NatureChemistry
nature.com
Nature Chemistry - Nitrile-containing molecules and their biosynthetic enzymes are uncommon in nature. Now, a nitrile-forming diiron enzyme involved in the biosynthesis of aetokthonotoxin���the...
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I am very proud of a first year PhD student in my lab, Xianghu Wang, for his paper on how to improve molecular networking with graph topology algorithms just published in @J_ASMS! The whole process was both helpful for improving the manuscript and smooth.
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A new paper in Science details the largest protein discovered to date. The protein, dubbed PKZILLA-1 by the paper’s authors, comes from the haptophyte alga called Prymnesium parvum: https://t.co/lMq6GShMFJ .
cen.acs.org
To make a giant molecule, nature devised a similarly giant solution
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Thank you to @cenmag for highlighting our work! https://t.co/sITFQrY8DC
cen.acs.org
To make a giant molecule, nature devised a similarly giant solution
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It was an honor to be a part of this. It was a GIANT team effort and I'm incredibly proud of this work and everyone involved. A big highlight for me was getting to work with my officemate @photocyte to divine how these GIANT enzymes generate these GIANT molecules.
Out today at @ScienceMagazine - giant PKZILLA proteins spew huge polyketide marine toxins, just like #Godzilla! Witnessed by @photocyte & @VikShende at @Scripps_Ocean
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I am happy to share our latest review article on bile acids and the microbiota modulating host immunity. Great effort by Mike Lee, together with Sean-Paul Nuccio, Ipsita Mohanty, Lee Hagey, @Pdorrestein1, and @theChuLab. Here is a link with the full text:
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