Another fascinating year of demonstrations by our group at the IRB Barcelona Open Day. Great to reach out to the community and show off the excitment of chemistry! Many thanks to @IRBBarcelona for organising this fantastic event.

Our PhD student, Sergi Rafael presented his thesis, Heterobifunctional Molecules: PROTACS and beyond. From overcoming degrader resistance to rewiring ERF activity, Sergi discussed his work with fantastic animations. Congratulations Dr. Rafael!!

La setmana passada vaig presentar la feina feta a @URSAchemlab a la @rqo_scq2025. Va ser un plaer poder participar-hi i veure la química fascinant que fem al país!

Congrats to our PhD graduate Dr. Marina Bellido (@marinabellidom) and PhD student Marti Sidro (@martichickpea) for their recent work in developing the p-stereogenic phosphane ligand, MAdPHOS, which provides outstanding enantioselectivities in asymmetric hydrogenation of enamides!

Check out our work preparing 3,3-diarylallyl phthalimides as single diastereomers. we use this approach to synthesise various cyclopropylamines and achieve their highest enantioselectivities reported to date! https://t.co/jlqb4OM4O5 Congrats to Martí Sidro (@Maarti164 ) et al!

Day out with the group before cooling off for August, happy vacations!

Our PhD student Sergi Rafael presented his work at @IRBBarcelona as part of the Research Nodes Seminar series. He explained his exciting research in Proximity-induced Pharmacology and its application toward developing novel treatments for evasive cancers. Well done Sergi!

We report a greener preparation of these chemical intermediates and demonstrate their versatility by incorporating this methodology into the formal synthesis of the pharmaceutical Apremilast. Congratulations to Dr. Marina Bellido (@marinabellidom) and all authors involved! 2/2

☑ 3 Component Synthesis ☑ 2 Step Tandem Reaction ☑ 1 Pot We are delighted to report our novel synthetic approach for synthesising (2-Arylallyl) Aryl Sulfones! 🧪 @AdvSynthCatal Check it out: https://t.co/Q7Lsz2Zo6n 👇(1/2)

#PCBCommunity | @CrisMayorRuiz, group leader del laboratorio de Degradación Dirigida de Proteínas y Descubrimiento de Fármacos del @IRBBarcelona, gana el Premio 60 Aniversario Farmaindustria Jóvenes Investigadores. ¡Felicidades! 👏🔝 @Farmaindustria #cancer

Our recent paper in collaboration with Dr. Cristina Mayor-Ruiz has made the cover of Angewandte! Congratulations to our PhD student/graphic design wizard, #Sergi Rafael and all the authors involved in its design!

#IRBBarcelona scientist @CrisMayorRuiz to participate in the @CancerGrand team #PROTECT, to apply targeted protein degradation against various types of paediatric tumours. @ContraCancerEs is involved in this global funding initiative and supports this project, which will last

En esta convocatoria de @CancerGrand Challenges, en @ContraCancerEs apoyamos a la Dra. @CrisMayorRuiz (@IRBBarcelona) y su participación en el proyecto PROTECT para el desarrollo de tratamientos efectivos para cánceres infantiles. #investigandoencáncer ➡️ https://t.co/yQNOR2kmYR

🆕Chemical rewiring of ubiquitination by #degraders and their selectivity routes. ✍️Rory Whelan & @CrisMayorRuiz 📰🎂@NatureSMB’s 3⃣0⃣th anniversary issue! 🔗 https://t.co/idFNyeoSX6 📌 https://t.co/UVwOW15Mto #IRBScience #TPD

💊New drug reveals a key mechanism to overcome resistance to #ProteinDegraders. ✍️ @BarbMGBarbosa @KarenSfyaki @ferran_jose99 Sergi Rafael @CrisMayorRuiz @URSAchemlab et al. 📰 @angew_chem ➡️ https://t.co/CzvCF8rZ1r 📌 https://t.co/gzR41WRuqX #IRBScience #TPD

A great day at the @_BIST Forum 2024! Congratulations to Dr. Antoni Riera and Dr. @SaraSdelci who presented their project EXPLODE-TNBC. This work aims to apply targeted protein degradation to find treatments for the elusive breast cancer type, Triple-Negative Breast cancer.

📢We are hiring! #PhDposition at @VHIO 🎯We aim to uncover novel patterns of chromosome instability in #cancer using 💻multi-omic analyses 🧬functional validations 💊to impact in patients My group▶️ https://t.co/4ud5b46zdS Apply▶️ https://t.co/icA3Q33e32 Questions? DM or email!

We apply this wide-scope reaction toward the synthesis of curcuquinone and the σ1 receptor agonist RC-33. Special congratulations to Dr. Marina Bellido and Carlos Riego! (@carlosriego_99) (2/2)

A busy week for publications in @URSAchemlab! Check out our accepted article in @AdvSynthCatal. We report an aluminum-catalyzed regioselective isomerization of 2,2-disubstituted oxetanes to yield homoallylic alcohols. https://t.co/9ngrysKYwM 👇(1/2)

Thrilled about our collaboration with @CrisMayorRuiz lab. This work identifies synthetic lethal vulnerabilities of cancer cells that exhibit widespread #resistance to #degraders! Congrats to Sergi Rafael and Dr. Carolina Sanchez (@URSAchemlab) and all co-authors!