César Serrano García
@DrCeSarcoma
Followers
3K
Following
13K
Media
391
Statuses
4K
Physician-scientist · #sarcoma #GIST @VHIO | External Group Leader @IRBBarcelona | #SanidadPública | #SinCienciaNoHayFuturo | @MyEsmo Faculty. Tweets are my own
Barcelona / de Salamanca
Joined June 2018
🤩 Ha sido todo un honor recibir la beca CRIS de Excelencia dotada con 1.25M€ para diseccionar a un nivel sin precedentes los mecanismos moleculares de los #Sarcomas #GIST - y poder avanzar en el tratamiento de nuestros pacientes 🧬💊 🙏🏼 Muchas gracias a la #CRIScontraelcáncer
🔴 Para el Dr. @DrCeSarcoma del @VHIO de Barcelona por el Proyecto CRIS de Sarcomas Gastrointestinales. ➡️ Entrega el Dr. Kevin Harrington, jefe del servicio de Radioterapia e Imagen del @CTI_ICR. #CRIScontraelcáncer #OtraOportunidad #DíaCienciaCRIS24
44
30
218
🧬 Secondary Genetic Alterations in Translocation-Associated Sarcomas 📊 SGAs detected: 51% (88% in myxoid liposarcoma) 🧪 Most frequent: TP53 (ES 11%, SFT 26%) ⚠️ Prognosis: SGAs → ↑ metastasis & worse PFS/DSS 💡 TERT promoter mutations also linked to poor outcomes 🔗
ascopubs.org
PURPOSETranslocation-associated sarcomas (TASs) encompass a wide spectrum of pathologic entities and clinical behavior. Driven by the oncogenic fusion, TASs typically show a stable genome and a low...
0
5
10
🧬 Recientemente publicado en @JAMAOnc: un grupo internacional de expertos, liderado por @DrCeSarcoma (#VHIO), publica la primera guía de recomendaciones del uso de la secuenciación genómica en el manejo de pacientes con #sarcoma ➡️ https://t.co/hLFjyiJgnq
0
3
8
Abierta la 1ª convocatoria de la Beca ENARAK BEHAR ZAITU 28.000 € + 2.000 € para gastos indirectos, para proyectos de investigación en sarcomas retroperitoneales. 📅 Plazo: hasta el 15 de noviembre de 2025 📩 secretaria@grupogeis.org 👉 Más info: https://t.co/Y24VMCtF38
0
3
3
📣 New VHIO-@CaixaResearch Scientific Seminar‼️ 🔹 Transcriptional Dysregulation in Cancer 👩🔬 Dr. Ping Chi, @MSKCancerCenter & @WeillCornell 🗓 Friday, 31st October at 12h Hosted by: @DrCeSarcoma Register at 👉 scientific.seminars@vhio.net
0
2
5
Long-term Nirogacestat in Desmoid Tumors — DeFi Trial 📊 Ph III, ≥4y follow-up ✅ ORR 45.7% (↑ CR + PR) ⏱️ mPFS not reached 📉 Ongoing tumor shrinkage + QoL benefits 💊 TEAEs ↓ incidence/severity ➡️ Nirogacestat maintains efficacy & tolerability 🔗 https://t.co/VyDdsMU77c
0
8
20
9,606 Chinese physicians joined virtually for the “Dialogue on Bone and Soft-tissue Tumor Standard of Care” during ESMO 2025. A heartfelt thank you to all the speakers for making this event a success! @herbloong @CUHKMedicine @DrCeSarcoma @VHIO @seppobauer #bone #sarcoma
1
2
4
💬 Sara Cervelló, paciente y miembro @CMMetastasico, y @DrCeSarcoma, jefe de grupo #VHIO, te invitan a la Jornada de Participación de Pacientes en la Investigación Oncológica del VHIO. 🗓️ 5/11 ⏰ 9 h 📲 Inscríbete ➡️ https://t.co/mt337Um8Sq
#SOMMVHIO
https://t.co/K11sT8tF1o
0
3
4
‼️🆕 Just published in @JAMAOnc: Consensus guidelines for the use of #NGS in #sarcoma pts: 🤔Little data supporting routine, nonselective use 🔬💊Potential benefit in selected entities 🏥Sarcoma experts are critical 🧬BUT we need more molecular data! ▶️ https://t.co/FZoVvA5EMm
4
23
56
I wish all spider plots from sarcoma trials would look like the one from the recent update of the DeFi trial leading to regulatory approval of nirogacestat in US and Europe for our patients with desmoid fibromatosis. https://t.co/MFHuEfp4Cx
0
7
19
#ESMO25 this couldn't be more timely ! "Guidelines for Next-Generation Sequencing in Sarcoma Diagnosis and Treatment" out in @JAMAOnc
@DrCeSarcoma et al.! @jeanyvesblay See the very wise conclusion! + full paper here: https://t.co/4cwvaZRrXc
1
11
22
📣 @GrupoGeis 2025 STS #Guidelines 🧬 Multidisciplinary mgmt in expert centers 🩻 MRI pre-biopsy; Core needle biopsy in referral units 💊 Surgery w/ clear margins key; RT/ChT select cases 🎯 Systemic tx: Doxo, Ifo, trabectedin, Gem , Eri, TT… 🔗 https://t.co/FtCSV5iEGO
0
5
10
Great lab and outstanding PI!
🚨Open postdoc position at @VHIO - Barcelona! 🧑🔬Willing to pursue an academic career? 🧬Are you passionate about #DNArepair #ChromosomeInstability #TumorEvolution 💊Willing that your research impacts on patients? 💻 https://t.co/4ud5b46zdS Please apply 👉 https://t.co/2Z2xU0GvjM
0
2
1
Highly recommended!! 👇👇
🚨Open postdoc position at @VHIO - Barcelona! 🧑🔬Willing to pursue an academic career? 🧬Are you passionate about #DNArepair #ChromosomeInstability #TumorEvolution 💊Willing that your research impacts on patients? 💻 https://t.co/4ud5b46zdS Please apply 👉 https://t.co/2Z2xU0GvjM
0
2
2
🚨Open postdoc position at @VHIO - Barcelona! 🧑🔬Willing to pursue an academic career? 🧬Are you passionate about #DNArepair #ChromosomeInstability #TumorEvolution 💊Willing that your research impacts on patients? 💻 https://t.co/4ud5b46zdS Please apply 👉 https://t.co/2Z2xU0GvjM
0
10
11
Hot off the press! 📷 Our new article on PRRX1-rearranged fibroblastic tumors. https://t.co/3ZsH7pfAEC
#pathology #BSTPath #oncology
2
16
40
Our REPAIRome study finally out today in @ScienceMagazine !!! https://t.co/LOJHQa4Yqe
science.org
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels)...
14
24
100
Now online in @CD_AACR: Epigenetic and Transcriptional Programs Define #Osteosarcoma Subtypes and Establish Targetable Vulnerabilities - by Eunice López-Fuentes, @ASweetcordero, @SweetCorderoLab, and colleagues https://t.co/QqehgR8Yym
@UCSF
1
9
15
Now online in @CD_AACR: Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase - by Yang Bai, @Samuel_Bakhoum, @mittallab, and colleagues https://t.co/no8n3BGJET
@WeillCornell
0
20
67
Secondary genetic alterations can alter the morphology and behavior of fusion-driven sarcomas - this Ewing sarcoma exhibits variant biphasic morphology correlating with subclonal TP53 mutation (IHC is p53)
4
15
60
Quedan pocos días para la Sarcoma’s Week 📚Curso anual Sarcomas (1-2 Oct) 💪Workshop IMPERAS (1 Oct, 4ª Edición) 🔬2º Curso de Sarcomas de IMPERAS (2 Oct) ✍🏼Curso de Enfermería en Sarcomas (2 Oct) 🙌Simposio de Pacientes (2 Oct) 🌍XXIII GEIS International Symposium (3 Oct)
0
8
9