Luke McAlary
@LukeMcAlary
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Researcher from Molecular Horizons and UOW trying to find out cause and cure for MND
Joined September 2012
New research from our lab lead by Dr Christen Chisholm and supported by our team. We developed a biological degrader that targets misfolded forms of the SOD1 protein involved in MND. Check it out! https://t.co/ruhbkVSptm
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Great to see this work by our team, lead by PhD student Thomas Walker. We found that the heat shock protein HSPB5 is a powerful chaperone that prevents TDP-43 fibrillation AND maintains TDP-43 condensate fluidity even more than its sibling HSPB1.
Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP-43 low complexity domain https://t.co/2BjRUIb7SB
#biorxiv_biochem
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Excited to share our new review on biomolecular condensates in Adv. Mater.! We explore the latest insights from both computational and experimental perspectives. Huge thanks to collaborators across QUBIC nodes for making this possible! Read here:
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Very proud of this work and fantastic collaborative effort! @TheFlorey @neuraustralia @nervecentrals @WolfVucic @MonashBDI @MAPP_latrobe @FightMND @MND_RIA
https://t.co/UWY2hPSSjl
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A large-scale analysis of U.S. water quality data reveals that most toxic chemicals remain poorly characterized or undetected in routine monitoring. The findings in Science suggest that the true scale of chemical risk to biodiversity and ecosystems may be significantly
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Dr. Bedlack is known in the ALS community for his rockstar suits, and his non-conventional wardrobe is also a reflection of his out-of-the-box approach to finding a cure for ALS. To watch a trailer for his Stitching Strength documentary, visit https://t.co/AnJweegh1t
@DukeU
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š§ The #LongitudePrizeOnALS is now live! This Ā£7.5M challenge invites innovators across #biotech, #AI, and #data science to help accelerate #ALS treatment discovery. Join us in bringing AI to the fight against ALS. Learn more: https://t.co/ZnMcBIi7jT
#LPALS #MND
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New cocktail š¹ in town - in collaboration with @BenLehner : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait šØ of an amyloid transition state. Read about it in this great thread by co-first author @immunobananna
Alzheimerās disease š§ starts with a molecular domino effect - but what triggers the first piece to fall? In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. š§µš https://t.co/PQZcE4bGwN
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We love you, Neale š The Dees and Pies form a guard of honour for the great Neale Daniher. Donate to support @FightMND at https://t.co/2IbisnZiU1.
#BigFreeze11
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MND&NR Lab getting ready to sell FightMND Big Freeze 11 Beanies at the Adelaide oval Crows versus Lions @FightMND @Adelaide_FC
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Proteomics Analysis of the TDP- 43 Interactome in Cellular Models of ALS Pathogenesis https://t.co/RkdSC01uQd
onlinelibrary.wiley.com
Cytoplasmic aggregation and nuclear depletion of TAR DNA-binding protein 43 (TDP-43) is a hallmark pathology of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS),...
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Great New Work from Molecular Horizons at UOW led by Reuben Young in Shane Ellis' lab. Reuben amazingly got Mass Spectrometry Imaging of lipids down to sub-micron resolution!!! This allows intricate examination of cell lipid profiles in tissues. https://t.co/61ae5Dn2F4
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Big Freeze 11 Beanie is here! The future of MND is yet to be written. It's now time for us to write it. Live it forward and grab your Big Freeze 11 Beanie from Coles, Bunnings, select Shell Reddy Express stores and online at https://t.co/jN0Q0oiUTh š§ #LiveItForward #BigFreeze11
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New publication. We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With @Bennibolo @CRGenomica @sangerinstitute @IBECBarcelona
science.org
xAI trained on >100,000 random peptides predicts and elucidates primary sequence determinants of aggregation.
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Tomorrow is #ALSAwarenessMonth! Help make ALS history and amplify the voices of those affected by #ALS. Urge your lawmakers to officially recognize May 2025 and support the fight against this devastating disease. Take action: https://t.co/Q2QvaVajxH
#ALSAdvocacy
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TDP-43 toxic gain of function links ALS/FTLD-TDP and Alzheimerās Disease through splicing:
biorxiv.org
Loss of nuclear TDP-43 splicing activity is a common feature across neurodegenerative diseases, but its relevance to Alzheimerās disease (AD) remains unclear. Here, we show that TDP-43 pathology in...
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I am the 3rd person in the world to receive the @Neuralink brain implant. 1st with ALS. 1st Nonverbal. I am typing this with my brain. It is my primary communication. Ask me anything! I will answer at least all verified users! Thank you @elonmusk!
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Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement:
molecularneurodegeneration.biomedcentral.com
Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects the motor neurons, causing progressive muscle weakness and paralysis. While research has focused...
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ā©Most people with ALS lack known mutations, making early detection tough. We built an AI model using data from 47k+ people in 13 countries to spot risk, even without family history. Proud to support this with @AlfredoIacoange ā¦ā¦@AmmarAlChalabiā©
medrxiv.org
A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected...
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8/8 What does this mean though? It means 3 things. 1. this polytherapy could be a new treatment for SOD1 ALS 2. That other drugs can be added to this formulation 3. That other researchers might consider multidrug approaches in their own work
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