🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/5 https://t.co/Z4FqTvFE8X

In honor of Richard Slayman, the first pig kidney recipient, we hosted a workshop gathering global experts in xenotransplantation to explore unpublished clinical and ethical advances in kidney, heart, and liver transplantation. #Xenotransplantation #TransplantInnovation

Scientists have found that C/EBP⍺ activates an IRF8 #enhancer, driving its expression in early myeloid progenitors and specifying type I conventional #DendriticCell lineage. @washu_pathology @JingNeticist Read more in Science #Immunology: https://t.co/stvtqL9ZPb

He’s thriving nearly 4 months after receiving a gene-edited pig kidney at @mgh_transplant @MGHSurgery @MGHKidneys @harvardmed. “He was tired of just surviving. A pig kidney gave him a shot at living.” @CNN 🔗

@LVRiella @MGHSurgery @AST_info @karinarlima @CrisBonorino

💡 Takeaway: Innate immune checkpoints like Siglec-E/7/9 are emerging as crucial regulators of transplant rejection. 4/5 📄 Newsroom @MGBResearchNews:

✅ Blocking NF-κB or TNF-α in Siglec–E–deficient models restores graft survival. ✅ In humans, higher expression of SIGLEC7/9 (homologs of Siglec-E) is linked to better allograft outcomes—highlighting their potential as biomarkers or therapeutic targets. 3/5

✅ Siglec-E suppresses dendritic cell activation, limiting NF-κB signaling and TNF-α production. ✅ Loss of Siglec-E accelerates rejection in murine heart, kidney, and skin transplants through heightened T cell–mediated immunity. 2/5

🚨 Great Opportunity! 🚨 The @LVRiella lab, @mgh_transplant, is seeking a Postdoc in Transplant Immunology with expertise in Microsurgery. 📍 Apply now! #Postdoc #Microsurgery #TransplantResearch

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🚨 Breaking Records Again! 🚨 For 13 years in a row, our transplant teams have saved more lives through #OrganTransplantation than any hospital in New England. 👏 Shoutout to our patients, care teams and researchers for an amazing year in 2024! #TransplantInnovation #DonateLife

Hot off the press 👇🏼👇🏼

🚨BREAKING: Our report on the first-ever pig kidney xenotransplant in a living human with ESRD is now published in @NEJM! A major milestone in transplantation, paving the way for a new era of organ replacement @mgh_transplant @MGHKidneys @eGenesisBio more:

Cotransplanting hearts with kidney and donor bone marrow transplants in nonhuman primates achieves long-term tolerance of hearts without immune suppression, according to new @ScienceTM research that could inform future transplantation strategies. 📄: https://t.co/SpwcIvkLKT

1/5 🚨 Which exercise modality works best for patients with kidney disease? 🔬 Our latest study, published in @FrontPhysiol investigates the impact of various exercise modalities on chronic kidney disease.Check out our findings! 🧵👇 @mgh_transplant @hugodlcorrea @ThiagoJborges

An opportunity! Please consider

Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading

Great opportunity! I learned a lot 👇🏼👇🏼👇🏼👇🏼

Excited to share our latest review on C-type lectin receptors @emboreports ! From expression & ligand recognition to their crucial roles in immune function, this incredible family of PRRs has so much more to reveal! @gordon_d_brown @MRCcmm https://t.co/WzKT7Vut2A

Bringing CRISPR diagnostics for pointofcare genetic testing of kidney disease. Great collab with Michael Kaminski. From my lab, kudos to @lapeisa for all her major contributions