Stephen Sykes
@TheSykesLab
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Sykes Lab focused on the study of healthy and malignant hematopoiesis.
Missouri, USA
Joined May 2019
Happy to see our study finally published in @BCD_AACR! π Thanks again to the lead authors @mp_hartmann, Maximilian SchΓΆnung and all collaborators who helped to put together the bits and pieces of this exciting story! ππ
Just published in @BCD_AACR: Molecular Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in JMML, by @mp_hartmann @dlipka1 Check out new insights into cell-of-origin, and repurposing anti-CD52. https://t.co/q7XTNFXmzI
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Dr. Ross Levine (@rosslevinemd), Senior Vice President of Translational Research at MSK, has been named MSK's new Chief Scientific Officer (CSO). Dr. Levine will be responsible for setting and leading strategy for basic and translational research, including programs, centers,
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How it started (undergrad who thinks grant writing is funπ€) vs how itβs going (A PAPER IN BLOODπ©Έ!) excited to share the FULL ATF6 story with the world! Thank you to my amazing co-authors and mentor @TheElfLab for helping my six year long dream come true! https://t.co/hArUnguTo9
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Read our latest #research on #extramedullaryAML published with @SpringerNature in @BloodCancerJnl Thanks to the @LeukemiaRF for funding this work! β¬οΈβ¬οΈβ¬οΈ https://t.co/XYAtBJOkZD
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I am deeply honored and immensly grateful to the scientific community at ISEH for receiving this award! And a big shoutout and thank you to all the brilliant and hard-working former and current members of my lab who made the progress possible that led to this award! π π
ISEH is thrilled to announce the recipients of the 2025 Society Awards, which will be presented at the ISEH 54th Annual Scientific Meeting. Read more about each award recipient on https://t.co/2NCQisaloN
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Unsolicited advice to new PIs and my opinion only not fact: As a new Assistant Professor, you have a 1-1.5 year window where you can get an R01 without a corresponding author paper IF you have a high impact 1st author paper from your postdoc. After that, it seems no amount of
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Thrilled and honored to have received an @AIRC_it StartUp grant to support my leukemia research here at @unipr !
Biomarcatori tumorali e lotta alle #leucemie acute Due nuovi progetti di ricerca di #unipr finanziati da @AIRC_it per la Ricerca sul Cancro βΆοΈMy First AIRC Grant ad Alessandro Bertucci e Start-Up Grant a Orsola di Martino #RicercaUnipr #StudiareAParma
https://t.co/zpjoLN8uug
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Our preprint using EGFL7 to expand HSCs is FINALLY out ππ» π π©Έ
biorxiv.org
Understanding the pathways regulating normal and malignant hematopoietic stem cell (HSC) biology is important for improving outcomes for patients with hematologic disorders. Epithelial Growth Factor...
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Delighted to see our CLN1 & CLN2 Enteric Nervous System gene therapy paper published in @ScienceTM today! Big team effort with many great colleagues @HeuckerothLab @WashUMedPeds & directly inspired by Batten families @BDSRA @NIH_NINDS @noahs_hope1
https://t.co/yTQSRXGY66
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Excited to share our latest work published today in @SciImmunology and featured on the cover! This study demonstrates that thrombospondin-1 (Thbs1) is a driver of hematopoietic aging and that targeting Thbs1 suppresses inflammaging and restores systemic and HSC healthspan.
Science #Immunology's January issue is out! This month's cover depicts how deleting #thrombospondin1 can reverse aging-associated defects known as #inflammaging in hematopoietic stem cells in mice. Read this research and more: https://t.co/ahHsEjdd3D
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@c_constan Entirely the wrong spin. A positive spin is that LLMs can be used to integrate interrelated findings to develop research questions to be tested. Until the experiment is run it is foolish to assume we know the outcome no matter who is doing the predicting.
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Very fun and productive collaboration with Bobby Bowman & @rosslevinemd modeling mutation order and oncogenic dependency in AML. I've always wanted to do this but we were previously limited by available tools... this is a huge step forward!
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My very talented graduate student @nsarellano9 wrote a highlight in @eLife on beautiful work by first author Rebecca Warfvinge that links cellular heterogeneity in CML stem cells to TKI response. Check both out below! https://t.co/q3rylWgvFS
https://t.co/yi8kq9HEic
elifesciences.org
Single-cell analysis of CML patients bone marrow at diagnosis reveals coexistence of CD26-CD35+ healthy stem cells and CD26+CD35- CML stem cells, and how the ratio between these impacts TKI response.
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T-48 hrs until the start of our 3rd Annual @WashUHeme Retreat! Excited to hear about the latest research from our trainees & faculty, and especially thrilled to welcome @aswolberg for the Evan Sadler Special Lectureship! #hematology @WashUDeptMed
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Here's the workshop I really want to attend: "how to use ChatGPT to fill out mindless university bureaucratic paperwork"
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BM Fibroblasts -say what π Our paper is finally out!! Using our unique model of AML with long latency to investigate changes in BMM before disease onset: https://t.co/l1ZHsD12m2 𩸠𧬠π§ͺ #AML #Leukemia #Fibroblasts #microevironment
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You truly wonβt believe your eyes when you come to Sundance for #WBC25!!!!
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