This was a long time coming and was spearheaded by the amazing @pradeepvpr! Congratulations to Pradeep and all our talented crew that helped us along the way. Thank you to @ClaireOlingy and all the reviewers for making this a great experience.

Excited to share our latest work published today in @SciImmunology and featured on the cover! This study demonstrates that thrombospondin-1 (Thbs1) is a driver of hematopoietic aging and that targeting Thbs1 suppresses inflammaging and restores systemic and HSC healthspan.

We would like to thank the Editors at @NatureComms for making this process painless and smooth. As well as our reviewers, particular @ChuteLab, for their constructive comments. Your suggestions most definitely improved the manuscript.

In summary, this study defines NTN1 as critical growth factor that regulates aging of the BM niche, and describes a novel role for NTN1 in reactivating DDR within aged BM vascular cells, mesenchymal stem cells and HSCs.

Lastly, NTN1 restores the regenerative capacity of an aged hematopoietic system to endure serial chemotherapy by enhancing hematopoietic recovery and survival. These findings could have tremendous therapeutic impact.

Mechanistically, we found that NTN1 is a regulator of DNA damage responses (DDR) within the BM niche and that NTN1 treatment reactivates the DDR, resolves physical DNA damage, and restores functional potential of the aged BM niche.

Additionally, NTN1 mediated niche rejuvenation was sufficient to restore functional capacity of aged (18 month old) HSCs back to youthful levels (3 month old), as evidenced by stringent assays to evaluate stem cell potential.

When we supplemented aged mice with recombinant NTN1, we were able to restore the fundamental defects of an aged BM niche including restored vascular integrity, oxygenation and MSC activity.

In this study, we demonstrate that deletion of Netrin-1 (NTN1) in LepR+ MSCs and BMECs in young mice results in premature aging of the BM niche including vascular disruption, adipocyte accumulation, and HSC dysfunction.

Very excited to share our recent publication showing that restoring BM niche function rejuvenates aged HSCs @NatureComms ( https://t.co/bTCGRh2KNU)! Congrats to @pradeepvpr, @GusThePolice, @mc_gutty, and the rest of the talented crew!

I'm also so proud of everything we accomplished as one of the founding labs at the Center for Discovery and Innovation @HMHNewJersey. I want to thank everyone for making my time there special. Looking forward to all the great things the CDI will accomplish in the coming years.

Though it feels great to be back home, I will forever miss NYC. The past 16yrs have been spectacular. Thank you to all my past lab colleagues and thank you to my current lab mates continuing this journey with me and those starting new adventures!

Excited to announce the lab has moved to @UFMedicine @ufhealthcancer. Equally excited for my new role as Vice Chief of Research in Hem/Onc. Many thanks to @DrMarkham & @jdlicht for this wonderful opportunity. Looking forward to working with this amazing scientific community!

So delighted to welcome an exceptional physician-scientist, science 🧬 #Vascularbiology pioneer & good friend to AAP - Shahin Rafii ⁦@Cornell⁩ (who needs to get on twitter!)

Check out our new paper in Development! Vascular endothelial growth factor-c regulates hematopoietic stem cell fate in the dorsal aorta | Development | The Company of Biologists

Check it out! Our very own @anu_res Anurag Maganti was 1 of 26 med students across the country to receive the 2021 @ASH_hematology HONORS (Hematology Opportunities for the Next Generation of Research Scientists) Award here at the @HMHSchoolofMed and CDI! https://t.co/6zZFBub8V4

So excited to share our newest paper on R-loops and HSC dev. Way to go @JoshWeinreb1 and collaborators @postdocpotts @GhazaleNoura @Amitvermamds @sloliveira and more

Finally out @CellStemCell! IL33 modulates #EndMT in the human bone marrow during regeneration episodes. How does this relate to #TGFb? Next episode... Thanks to everyone involved, specially M. Raaijmakers @ErasmusMC.

Alright New Yorkers — and those who love NY — let's make this go viral.

Everything always somehow comes back to the vasculature.