James Thaventhiran
@Thav_Lab
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Clinical Immunologist, studying how genetic or therapeutic loss of an immune checkpoint leads to disease.
MRC Toxicology Unit
Joined November 2015
We show that vaccine protection and neutralising antibodies wane more rapidly in people with obesity. https://t.co/arCZUe8lcE Huge collaborative effort from my lab in @MRC_TU with @Farooqi_Lab @DrAzizSheikh @LintermanLab supported by @UKCovidVaxHub
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Now she’s teaching me about pandemics and symptoms: Helen Thaventhiran · No Dose for It at the Chemist: William James’s Prescriptions
lrb.co.uk
William James was acutely sensitive to both his own disabling pain and the wriggling ironies of his super-subtle family...
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It is a lovely study demonstrating something that affects many of us now.
Our analysis of cognitive changes during the Wildtype SARS-CoV-2 Human Challenge Study is now out. We observed subtle memory, executive and attentional performance decrements post-pre infection in mild cases. https://t.co/uPGruMikJu
@ImperialBrains @eClinicalMed @iamcognitron
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Really great to be able to help @hollfelderlab with this great project. Really excited to continue using this technology.
nature.com
Nature Biotechnology - Antigen-specific antibodies secreted by plasma cells are rapidly identified using microfluidics and fluorescence-activated cell sorting (FACS).
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The mRNA therapeutic potential is huge: Combined COVID-flu vaccines are coming: Moderna jab clears major test
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🎉New paper🎉Introducing #StrandInteractions, the sequel to #LesionSegregation, published today @Nature Strand-resolved mutagenicity of DNA damage and repair https://t.co/VTP3h139Q4 Here’s what we discovered about (a)symmetry in replication, transcription & #mutagenicNER [1/13]
nature.com
Nature - How strand-asymmetric processes such as replication and transcription interact with DNA damage to drive mechanisms of repair and mutagenesis is explored.
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I hope lots of people will use it!
An antigen signaling fate-mapping mouse reveals that intratumoral antigen signals trap CD8+ T cell clonal populations in tumors @SciImmunology @Thav_Lab
https://t.co/3cVIecyQZv
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This just out. Really hard work from Munetomo and Ty. Summary to come. Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site | Science Immunology
science.org
An antigen signaling fate-mapping mouse reveals that intratumoral antigen signals trap CD8+ T cell clonal populations in tumors.
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The first student I supervised in the Fearon lab — makes me proud — The pressing need for allyship - Cancer Research UK - Cancer News
news.cancerresearchuk.org
Building a truly inclusive research environment is more than a moral imperative says Dr Ed Roberts, it is vital for research success…
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Very impressive research studying the impact of obesity on immunity in a resource poor environment under difficult circumstances with a lot of determination! Really enjoyable day for me.
Many congratulations to our fab student Mohammad Ali @AliMdKochi for passing his DPhil viva today on impact of DM & obesity on COVID immunity in Bangladesh. Many thanks to examiners Helen McShane & James Thaventhiran @Thav_Lab. Ali is now off to postdoc for @PKlenermanLab
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Many congratulations to our fab student Mohammad Ali @AliMdKochi for passing his DPhil viva today on impact of DM & obesity on COVID immunity in Bangladesh. Many thanks to examiners Helen McShane & James Thaventhiran @Thav_Lab. Ali is now off to postdoc for @PKlenermanLab
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A great time to be a clinical immunologist.
@BSI_CIPN Steering Group: Dr Emma Callery @LancsHospitals – #HealthcareScientist Representative Dr Leman Mutlu @LemMutlu – #PatientGroup Liaison Dr James Thaventhiran @Thav_Lab – Conference Programme Lead 5/6 🧵
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SEMINAR: The Immunity scales – how obesity weighs in on immunity, Dr James Thaventhiran @Thav_Lab @MRC_TU Tuesday 27th February, 1.30-2.30pm Details: https://t.co/KAyOdo2Ze2
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Had an incredible experience collaborating on the "Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments" project. Truly groundbreaking work with an amazing team!
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This study highlights the resilience of the gut microbiome to host immune changes triggered by COVID-19 vaccination and suggest minimal, if any, impact on microbiome-mediated processes https://t.co/pmIMzXDYBJ
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Our research in this report is important for patients with primary immunodeficiency.
Does COVID-19 vaccination affect gut microbiome? We find minimal, if any, impact, even under immunodeficiency. Results encourage vaccine acceptance esp. considering large microbiome shifts observed during infection 🙏🏽 brilliant lab members + @Thav_Lab @MRC_TU @Cambridge_Uni ++
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New 2-year postdoc position available in my lab @TheCrick to test novel therapies for #IBD and related diseases by targeting a master regulator of #macrophage-driven inflammation using antibody-drug conjugates and related tools. Apply here: https://t.co/RXAUM2x7JQ Pls retweet!
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👁️🗨️ Curious about Age-Associated B Cells? 🧐 Dive into the video to understand why they are VITAL in the world of vaccine research. 💉🔍 Unlock the secrets behind immune response and protection for ALL ages! #VaccineResearch #AgeAssociatedBCells #ScienceExplained #StayInformed
🔬Dr @Thav_Lab investigates ways of improving therapies for autoimmune diseases such as lupus to decrease the risk of immunodeficiency after treatment. He also looks at responses to the #COVID19 vaccine in immunodeficient patients. @Cambridge_Uni #Autoimmunedisease #Lupus
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🔬Dr @Thav_Lab investigates ways of improving therapies for autoimmune diseases such as lupus to decrease the risk of immunodeficiency after treatment. He also looks at responses to the #COVID19 vaccine in immunodeficient patients. @Cambridge_Uni #Autoimmunedisease #Lupus
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