Svenja Saile
@SvenjaSaile
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Walter Benjamin fellow @PHIM_Research; interested in plant-microbe interactions 🌱; Former PhD student @ZMBP_Tuebingen
Joined June 2018
Fungal effector-mediated PTI suppression from the apoplast!
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I am excited to share my research is now published! 📚 An apoplastic fungal effector disrupts N-glycosylation of ZmLecRK1, inducing its degradation to suppress disease resistance in maize https://t.co/quqwkMZLtB
@SN and #SNAuthor.
nature.com
Nature Plants - This study reveals that a fungal apoplastic effector dampens plant immunity by disrupting the N-glycosylation of a cell-surface immune receptor, thereby promoting its...
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⚠️Excited to share my latest in @ThePlantCell🌱! We show that chloroplasts form membrane contact sites (MCS) with the pathogen interface to drive focal immunity, mediated by a tethering complex🔗! Full story 👉 https://t.co/LE3SVlxp5i
#PlantScience #PlantImmunity
academic.oup.com
Chloroplast tethering to the pathogen interface via membrane contact sites promotes focal callose deposition and strengthens plant immunity.
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Our latest paper is now online at New Phytologist! Phosphorylation-dependent association of a bacterial effector with plant 14-3-3 proteins enhances effector stability and bacterial virulence https://t.co/E4eiTqEcQf
@NewPhytol
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New preprint! We report the largest plant resistosome ever described. We revealed the wheat NLR WAI3, a member from the mysterious CCG10-NLR clade, forms an unprecedented octameric assembly with a unique channel architecture. And the well-known RPS2 might work the same way!
An activated wheat CCG10-NLR immune receptor forms an octameric resistosome https://t.co/iPwdmmx6yu
#biorxiv_plants
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The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard
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Fascinating effector mechanism to undermine host immunity. Plus a very cool effector 🎯: TOL9a 😎
An effector from the potato late blight pathogen bridges ENTH-domain protein TOL9a to an activated helper NLR to suppress immunity https://t.co/8W1MhZWuiP
#biorxiv_plants
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Plz RT. We are looking for a postdoc to join our collborative project on AI-guided bioengineering of plant immune receptors @Tolga_Bzkrt and @JiorgosKourelis labs:
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I’m excited to share our latest preprint on the cell biology of plant hypersensitive cell death! 🌱💥 We used live-cell imaging to unravel what happens after resistosome activation—one of the least understood phases of plant immune responses. https://t.co/WMy5AMjg0u
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In Arabidopsis, overexpressing BIR1 triggers immune responses and cell death, much like its loss. EDS1 and SOBIR1 are key players in this hypersensitive response, linking BIR1 to NLR surveillance. https://t.co/DHBKVEZ8gh
@wileyplantsci #OpenAccess
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A plant dual-kinase protein traps a pathogen effector to trigger immunity. https://t.co/btqAr5KIJN
nature.com
Nature Genetics - Tandem kinase proteins (TKPs) are key regulators of plant immunity. We found that RWT4, a wheat TKP, confers resistance to the fungal pathogen Magnaporthe oryzae by directly...
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The NLR immune receptor Roq1 recognizes the Pseudomonas syringae HopAG1 effector via its Nudix domain https://t.co/Fi3uvSd8tl
#biorxiv_plants
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Ever wondered where NLRP3 needs to be in the cell to activate the inflammasome? Turns out, it does not really matter. Check out our latest study in @NatureComms: https://t.co/sWVK5gWhYq See 🧵👇 1/9
nature.com
Nature Communications - NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants...
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The Magnaporthe oryzae effector Pwl2 alters HIPP43 localization to suppress host immunity (Vincent M Were , Xia Yan , Andrew J Foster , Jan Sklenar , Thorsten Langner , Amber Gentle , et. al.) https://t.co/dLNoleoGfk
@vinniman @ASPB #PlantSci
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“Science has no passport, no gender, no ethnicity, no political party” President @vonderleyen, with a new €500M initiative to attract top global talent. In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, & shared by all humanity.
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We have discovered plant cell penetrating peptides! Tag your protein of interest with these small peptides for direct protein delivery to plants! https://t.co/RRBB0Iugot
@plantae_org | #NIFAImpacts
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🚀 Exciting news for early-career researchers! The new Max Planck #Postdoc Program offers a guaranteed contract of at least 3 years, targeted mentoring, and career workshops. Applications are open now! https://t.co/mU5NBXMsDU
#ScienceCareer #PostdocProgram
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DISPATCH - Are you interested in intercellular communication and plasmodesmata? Take a look on the recent dispatch article from Rishikesh Bhalerao in @CurrentBiology: https://t.co/nwftwAPCjl
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🚀 Excited to share our latest preprint on engineering PRRs to enhance broad-spectrum disease resistance in diverse plant species! 🌱✨ Big thanks to all our collaborators! @ZMBP_Tuebingen @ThorstenNrnber1 @sardineboy_DING @jonathandgjones @Steidele_Tina
biorxiv.org
Conventional plant resistance breeding has primarily focused on intracellular immune receptors, while cell-surface pattern recognition receptors (PRRs) have been underexplored due to their comparat...
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Our new collaborative paper with @EmmanuelleBayer and her dream team is out: Regulation of plasmodesmata flow by the membrane lipid PI4P and ER/PM tether MCTP https://t.co/Z6oNEsBNYO
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