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Enoch Lok Him Yuen Profile
Enoch Lok Him Yuen

@EnochYuen

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Researcher at @imperialcollege with @Tolga_Bzkrt l Plant Immunity l Alumnus @CambridgeJBS l 100+ countries l Quizzer l Puzzler

London, UK
Joined May 2020
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@EnochYuen
Enoch Lok Him Yuen
1 month
⚠️Excited to share my latest in @ThePlantCell🌱! We show that chloroplasts form membrane contact sites (MCS) with the pathogen interface to drive focal immunity, mediated by a tethering complex🔗! Full story 👉 https://t.co/LE3SVlxp5i #PlantScience #PlantImmunity
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academic.oup.com
Chloroplast tethering to the pathogen interface via membrane contact sites promotes focal callose deposition and strengthens plant immunity.
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@EnochYuen
Enoch Lok Him Yuen
1 month
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@EnochYuen
Enoch Lok Him Yuen
1 month
🌿 Building on our earlier work showing that chloroplasts reshape and gather at the pathogen interface during Phytophthora infestans infection 🦠 https://t.co/4DsmdUVPNv
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onlinelibrary.wiley.com
For the first time, we show that epidermal chloroplasts are focally deployed towards the host–pathogen interface during infection by the potato blight pathogen Phytophthora infestans, implicating...
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@EnochYuen
Enoch Lok Him Yuen
1 month
Here is the simple summary figure 🌿 It shows how chloroplast–pathogen interface contact sites form via a CHUP1–KAC1 tethering complex, anchoring chloroplasts to the extrahaustorial membrane.
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@GuanghaoGuo
Guanghao Guo
2 months
New preprint! We report the largest plant resistosome ever described. We revealed the wheat NLR WAI3, a member from the mysterious CCG10-NLR clade, forms an unprecedented octameric assembly with a unique channel architecture. And the well-known RPS2 might work the same way!
@biorxiv_plants
bioRxiv Plant Bio
2 months
An activated wheat CCG10-NLR immune receptor forms an octameric resistosome https://t.co/iPwdmmx6yu #biorxiv_plants
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@miangoar
GAMA Miguel Angel 🐦‍⬛🔑
2 months
1/13 🧵 Today, Bindcraft was published in @Nature , one of the most famous AIs in biology for designing protein–protein interactions (PPI). In my opinion. Bindcraft represents one of the most important advances in the post–AlphaFold2 era.
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@Tolga_Bzkrt
Tolga Bozkurt
2 months
Big cheers to Edward on his last day with us . Thanks for being an awesome BSPP summer intern — we’ll miss having you around! #BSPP #PlantScience
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@dromius
Sebastian Schornack
3 months
#2025ISMPMI @Tolga_Bzkrt introduces the effector and immune processes occurring at Phytophthora haustoria. The helper NRC4 localises to haustoria and upon activation inserts itself into the extrahaustorial membrane forming punctuate foci. It seems activated NLRs beep annoyingly.
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@mpcontreras4
Mauricio Contreras
3 months
Thrilled to share our latest @biorxivpreprint! This work started during my PhD and was finished together with @JMadhuprakash. We found a Phytophthora infestans L-shaped effector that bridges a host TOL protein to activated NLRs to suppress immunity! https://t.co/1o24A1Rp2s 1/15
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@KamounLab
Sophien Kamoun
3 months
Effectors still rock 🎸 10 years after they were declared dead 😵 #EffectorWisdom
@biorxiv_plants
bioRxiv Plant Bio
3 months
An effector from the potato late blight pathogen bridges ENTH-domain protein TOL9a to an activated helper NLR to suppress immunity https://t.co/8W1MhZWuiP #biorxiv_plants
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@YiFeng_eYFP
Yi-Feng Chen
3 months
Excited to share that our preprint is out! We’ll be at IS-MPMI presenting two posters on this project: 💥7/14 – P-387: Calcium & resistosome dynamics during cell death 🍃7/16 – P-449: Organelle dynamics during cell death Feel free to stop by!
@AdamWu9527
Chih-Hang Wu
3 months
I’m excited to share our latest preprint on the cell biology of plant hypersensitive cell death! 🌱💥 We used live-cell imaging to unravel what happens after resistosome activation—one of the least understood phases of plant immune responses. https://t.co/WMy5AMjg0u
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@AdamWu9527
Chih-Hang Wu
3 months
I’m excited to share our latest preprint on the cell biology of plant hypersensitive cell death! 🌱💥 We used live-cell imaging to unravel what happens after resistosome activation—one of the least understood phases of plant immune responses. https://t.co/WMy5AMjg0u
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biorxiv.org
Plant nucleotide-binding domain leucine-rich repeat-containing (NLR) proteins act as intracellular immune receptors that assemble into resistosomes to execute immune responses. However, the subcell...
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@KamounLab
Sophien Kamoun
3 months
Massive #NLRbiology paper drop by Yi-Feng @YiFeng_eYFP Chih-Hang @AdamWu9527 and colleagues 👏 "Single-cell-resolved calcium and organelle dynamics in resistosome-mediated cell death." https://t.co/OWNrsnGuK0
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@Phil_Carella
Philip Carella
3 months
New Postdoc position (2yrs) available in our #EvoMPMI lab @JohnInnesCentre. Come and work with on harnessing the diversity of immune mechanisms to protect plants. https://t.co/oEUXWMK0ZN
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@AlexWGuyon
Alex Guyon
4 months
1/🚨 New preprint alert! Can mutualists and pathogens co-colonise the same living plant cell and what does that do to the plant membranes that surround these microbes?
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@mpcontreras4
Mauricio Contreras
4 months
I’m thrilled to share that I’ll be joining @ZMBP_Tuebingen as a Junior Group Leader in October 2025! My lab will explore the functional and structural diversity of plant immune receptors. 1/2 #NewPI #PlantImmunity #NLRs #PlantScience #StructuralBiology
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@KamounLab
Sophien Kamoun
5 months
Tweeps, please spread the word. We're still looking at recruiting a structural biologist (any level) @KamounLab to study plant-pathogen protein complexes especially in the context of coevolution. Direct inquiries welcome. Please include a cover letter. Applicant from US
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