Enoch Lok Him Yuen
@EnochYuen
Followers
459
Following
987
Media
30
Statuses
210
Researcher at @imperialcollege with @Tolga_Bzkrt l Plant Immunity l Alumnus @CambridgeJBS l 100+ countries l Quizzer l Puzzler
London, UK
Joined May 2020
⚠️Excited to share my latest in @ThePlantCell🌱! We show that chloroplasts form membrane contact sites (MCS) with the pathogen interface to drive focal immunity, mediated by a tethering complex🔗! Full story 👉 https://t.co/LE3SVlxp5i
#PlantScience #PlantImmunity
academic.oup.com
Chloroplast tethering to the pathogen interface via membrane contact sites promotes focal callose deposition and strengthens plant immunity.
2
45
114
Let's keep in touch: How membrane contact sites drive immune responses
academic.oup.com
Inside every cell, a pulsating network of molecular messengers orchestrates life's most critical conversations. While vesicular trafficking facilitates lon
0
10
33
Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses (Enoch Lok Him Yuen, Zachary Savage, Vojtěch Pražák, et al) https://t.co/8XS5lhr6Cc
@EnochYuen @ASPB #PlantSci
1
17
45
New opportunity to undertake a PhD in my group @JohnInnesCentre - if you’re interested in plant immunity and evolution check out the link!
biodtp.norwichresearchpark.ac.uk
The fossil record demonstrates that filamentous microbes invaded ancient plant cells with intracellular hyphal structures over 450 million years ago. To this day, a rich diversity of extant land...
4
47
104
Massive thanks to everyone involved and thanks to all our amazing collaborators!🙏☺️ @Tolga_Bzkrt @SchattatLab @imperialcollege @ImperialLifeSci @CUHKofficial @UniHalle @zacdsavage @Freddie_King00 @cristina_vuolo @TarhanEI @YYuanyang_Zhou @ysntmts @JennyPrautsch @CianDuggan
1
1
7
🌿 Building on our earlier work showing that chloroplasts reshape and gather at the pathogen interface during Phytophthora infestans infection 🦠 https://t.co/4DsmdUVPNv
onlinelibrary.wiley.com
For the first time, we show that epidermal chloroplasts are focally deployed towards the host–pathogen interface during infection by the potato blight pathogen Phytophthora infestans, implicating...
1
2
12
Here is the simple summary figure 🌿 It shows how chloroplast–pathogen interface contact sites form via a CHUP1–KAC1 tethering complex, anchoring chloroplasts to the extrahaustorial membrane.
1
0
4
New preprint! We report the largest plant resistosome ever described. We revealed the wheat NLR WAI3, a member from the mysterious CCG10-NLR clade, forms an unprecedented octameric assembly with a unique channel architecture. And the well-known RPS2 might work the same way!
An activated wheat CCG10-NLR immune receptor forms an octameric resistosome https://t.co/iPwdmmx6yu
#biorxiv_plants
4
23
94
Big cheers to Edward on his last day with us . Thanks for being an awesome BSPP summer intern — we’ll miss having you around! #BSPP #PlantScience
8
3
36
#2025ISMPMI @Tolga_Bzkrt introduces the effector and immune processes occurring at Phytophthora haustoria. The helper NRC4 localises to haustoria and upon activation inserts itself into the extrahaustorial membrane forming punctuate foci. It seems activated NLRs beep annoyingly.
1
21
69
Thrilled to share our latest @biorxivpreprint! This work started during my PhD and was finished together with @JMadhuprakash. We found a Phytophthora infestans L-shaped effector that bridges a host TOL protein to activated NLRs to suppress immunity! https://t.co/1o24A1Rp2s 1/15
1
46
111
Effectors still rock 🎸 10 years after they were declared dead 😵 #EffectorWisdom
An effector from the potato late blight pathogen bridges ENTH-domain protein TOL9a to an activated helper NLR to suppress immunity https://t.co/8W1MhZWuiP
#biorxiv_plants
4
6
41
An effector from the potato late blight pathogen bridges ENTH-domain protein TOL9a to an activated helper NLR to suppress immunity https://t.co/8W1MhZWuiP
#biorxiv_plants
biorxiv.org
Pathogens counteract central nodes of NLR immune receptor networks to suppress immunity. However, the mechanisms by which pathogens hijack helper NLR pathways are poorly understood. Here, we show...
0
16
43
Excited to share that our preprint is out! We’ll be at IS-MPMI presenting two posters on this project: 💥7/14 – P-387: Calcium & resistosome dynamics during cell death 🍃7/16 – P-449: Organelle dynamics during cell death Feel free to stop by!
I’m excited to share our latest preprint on the cell biology of plant hypersensitive cell death! 🌱💥 We used live-cell imaging to unravel what happens after resistosome activation—one of the least understood phases of plant immune responses. https://t.co/WMy5AMjg0u
2
6
26
I’m excited to share our latest preprint on the cell biology of plant hypersensitive cell death! 🌱💥 We used live-cell imaging to unravel what happens after resistosome activation—one of the least understood phases of plant immune responses. https://t.co/WMy5AMjg0u
3
49
125
Massive #NLRbiology paper drop by Yi-Feng @YiFeng_eYFP Chih-Hang @AdamWu9527 and colleagues 👏 "Single-cell-resolved calcium and organelle dynamics in resistosome-mediated cell death." https://t.co/OWNrsnGuK0
1
14
64
Single-cell-resolved calcium and organelle dynamics in resistosome-mediated cell death https://t.co/rXHs1pz7BZ
#biorxiv_plants
biorxiv.org
Plant nucleotide-binding domain leucine-rich repeat-containing (NLR) proteins act as intracellular immune receptors that assemble into resistosomes to execute immune responses. However, the subcell...
0
31
50
New Postdoc position (2yrs) available in our #EvoMPMI lab @JohnInnesCentre. Come and work with on harnessing the diversity of immune mechanisms to protect plants. https://t.co/oEUXWMK0ZN
0
61
102
1/🚨 New preprint alert! Can mutualists and pathogens co-colonise the same living plant cell and what does that do to the plant membranes that surround these microbes?
3
43
119