Sumeet Khetarpal
@SumeetKhetarpal
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Cardiology fellow @MGHHeartHealth. s/p IM residency @MGHMedicine and MD-PhD @PennMedicine. lipids, metabolism, genetics. Tweets my own.
Boston, MA
Joined February 2018
RT @cholsoon_jang: Happy to share our new story published in @Cell_Metabolism regarding oral fructose tolerance test and blood glycerate me….
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RT @PLOSGenetics: Does endothelial lipase (EL) contribute to triglyceride #metabolism?. Khetarpal et al show that EL collaborates with lipo….
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RT @pnatarajanmd: Our study led by @SumeetKhetarpal @MGHCVFellows & D Rader @PennGenetics uses human & murine genetic studies to show that….
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Lastly, I appreciate the tireless mentorship of @danrader333 (for 14 years and counting!), @pnatarajanmd, @PennGenetics, @MGHHeartHealth, collaboration of @JoeInGenes @MGLevin @akhilp2301 and all the coauthors. Excited to explore new facets of #metabolism with @LabSpiegelman! 😊.
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It also furthers our understanding of the physiological regulation of TG rich lipoprotein catabolism as inspired by human genetics (8/n).
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This work is relevant to ongoing therapeutic efforts seeking to inhibit EL as a means to increase “functional” HDL ( @AstraZeneca (7/n).
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We show in vitro and in vivo that EL likely “collaborates” with LPL to promote efficient TG rich lipoprotein breakdown, possibly through phospholipid and TG lipolysis of PUFAs which allows more TG lipolysis by the predominant TG lipase LPL (6/n).
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Our study shows that EL inactivation in mice and humans delays breakdown of polyunsaturated fatty acids on TG rich lipoproteins (5/n).
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We further show in mice lacking endothelial lipase and biochemical studies in vitro that EL is a key contributor to TG rich lipoprotein catabolism through TG lipolysis (4/n).
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Here we mined large human genetics studies (@uk_biobank, Million Veterans Program, and the global lipids genetics consortium) to show that a LOF missense variant in LIPG is associated with increased TGs in humans (3/n).
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Endothelial lipase (EL) is a key regulator of HDL through breakdown of phospholipids. Prior work from from @danrader333 @CDG_MDPhD @skathire @bvoight28 and many others have shown that genetic loss of LIPG/EL is a key regulator of HDL-C in humans (2/n).
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Thrilled to share our human and murine genetics work showing that endothelial lipase is a key enzyme in the breakdown of blood triglycerides: CC @danrader333 @pnatarajanmd @PennMedicine @PennMedicine @MGHHeartHealth @MGHMedicine (1/n).
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Fun to work on this editorial piece on an important question that has come up often as a fellow with the marvelous mentorship of @pnatarajanmd and @mchonig. Many gaps in how we assess risk of ASCVD that don’t fall cleanly in primary vs secondary buckets and impact therapy.
When a patient has subclinical coronary artery calcification, is that ‘primary’ or ‘secondary’ prevention? @SumeetKhetarpal @mchonig & I discuss this as it relates to premature onset in a Viewpoint @JAMACardio
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Excited to work with and learn from these stars and make exciting discoveries together and have fun along the way. In the words of @kobebryant, we don’t hang division banners 🐐.
Meet our new Postdoctoral Fellows! @KBlack2018 @SumeetKhetarpal @HageSprenger @AubreyMichi @DanaFarber @HarvardCellBio
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RT @danleisman: Friends don’t let friends write the Response to Reviewers’ Comments while hungry.
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RT @CircAHA: #OriginalResearch: Dysregulated phenylalanine catabolism abrogates healthy cardiac aging in a mouse model. A potential risk ma….
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RT @MarcusDGon: A couple years ago, we showed that dietary fructose enhances intestinal tumor growth. Today, I’m excited to expand these re….
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I’m not sure what’s harder to pronounce: farxiga or quinoa - thoughts?.
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