The Khetarpal lab at UVA is seeking a research associate (postdoc)! Please see the posting and reach out with any questions!

We have a job opening in the @SumeetKhetarpal lab! Research Associate, The Robert M. Berne Cardiovascular Research Center https://t.co/MdET8tQnPx

New! Online now: Paternal exercise confers endurance capacity to offspring through sperm microRNAs https://t.co/qD1eentGzQ

Honored to begin this week at @CleClinicHVTI leading new initiatives in CV genomics as: • Section Head, Haslam-Bailey Family Section of CV Genomics & Precision Medicine • Director, Center for CV Genomics & Data Sciences • William E. Macaulay Endowed Chair

Here is @Rongtian2's News & Views article: https://t.co/GgJkymqTkT @LabSpiegelman @rosenzweig_a

Thank you @Rongtian2 for the excellent News & Views article in @NatureCVR on our recently published article! Your piece nicely positions our findings in the context of cardiac metabolism and highlights key unanswered questions on PGC-1α, GDF15 and cardiac atrophy. 👏

Ever wonder what makes your heart get stronger with exercise? @SumeetKhetarpal uncovered a gene and secreted factor that make all the difference between the heart getting stronger and actually getting weaker. As always, really elegant work. With @LabSpiegelman and @rosenzweig_a.

Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.

@LabSpiegelman @rosenzweig_a @DanaFarber @harvardmed @BidmcCvi Oh and of course the @mghcvrc!

Please DM me or reach out on our website:

We are a budding young group looking to grow with your support and are recruiting for several positions (postdoc/fellow, grad/MSTP, undergrad, research specialists).

We apply a variety of approaches including molecular physiology in animal and cell models, proteomics, and genetics.

The Khetarpal lab is active as of Sept 2025 and is hiring at all levels! We study cardiac metabolism, lipids, and find new mediators of metabo-communication in exercise and heart diseases!

The CVRC welcomes new resident member @SumeetKhetarpal, MD, PhD. Dr. Khetarpal joins us from MGH, recently received the Burroughs Wellcome Fund Career Award, and just published his first @MedicineUVA-affiliated paper in @NatureCVR! Read more: https://t.co/ZiHGvAl1VX

Cardiac PGC1a is required for adaptations of the heart to exercise (in mice). A wonderful collaboration with the lab of Tony Rosenzweig. Sumeet is off to start his won lab at UVa (congrats!)

Thankful for the invaluable mentorship from @LabSpiegelman and @rosenzweig_a, along with several formative collaborations with @DanaFarber, @harvardmed, @BidmcCvi colleagues.

Our work may have implications for new actions of GDF15 on cardiomyocyte metabolism and in conditions of suppressed PGC-1α function, such as heart failure, aging, cachexia and others.

We find that PGC-1α, a critical transcriptional coactivator regulating oxidative metabolism, is crucial for exercise adaptations in the heart, in part through suppression of the stress-induced myokine GDF15.

Happy to share our manuscript published today on regulation of cardiac adaptation to exercise training by PGC-1α and GDF15 in @NatureCVR!

@CircRes Compendium on #Cardiopulmonary Disease and #Exercise Shen et al Research Letter "Exercise Mitigates #Diabetic #Cardiomyopathy by Suppressing #Ferroptosis via N-acetyltransferase 10" https://t.co/JhwSIgHQHE @lihabo @sumeetkhetarpal