Spencer Lab
@Spencer__Lab
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Our long-term goal is to understand the normal functioning of signaling pathways controlling proliferation and to understand how these signals go awry in cancer
University of Colorado Boulder
Joined August 2023
The Spencer Lab has an opening for a postdoc in the area of cell biology, cancer biology, or systems biology! Click below to apply! https://t.co/Vs30KFdzy7
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Our paper on CDK2 inhibition and cell cycle plasticity has been highlighted by the EACR as one of the most interesting and impactful recent publications in cancer research. See the full list here: https://t.co/77vyVx078n…
@EACRnews
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In the Spotlight from the March issue— A highly anticipated selective therapeutic agent against CDK2: INX-315, by @LotteWatts and Sabrina L Spencer. https://t.co/ium1G8ch8z
@CUBoulder
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https://t.co/O2A607jE0J Check out our In the Spotlight article - published today!
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Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids
cell.com
Amino acids are key inputs for cell growth and proliferation. Using time-lapse single-cell microscopy, Rong et al. found that cell-cycle arrest upon methionine and leucine starvation is mainly...
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Excited to share some of my PhD work in Spencer lab @lab_spencer355 on the control of proliferation versus quiescence by amino acid signaling! Special thanks to my collaborators @amcdarnell @ksapp17 of the @mvh_lab for making this project possible! ❤️
Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids
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Bands of cancer cell “escapees” allow several types of cancers to tolerate targeted therapies, a detailed subcellular map tracks the path of a signaling protein over time, and more in this week’s issue of #ScienceSignaling. https://t.co/H6CWN87Kic
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Small groups of “escapee” #cancer cells that mount replication stress responses may enable tumors to tolerate #MAPKInhibitors, shows a new study involving cell lines and spheroids of melanoma, lung, and colon cancers. https://t.co/up60BXRJCd
@CUBIOCHEM1
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Studying an array of cancer cell lines, a team discovers how #cancers often resist targeted therapies that exploit the MAPK pathway, which hints that suppressing stress tolerance might improve clinical responses to these important cancer drugs. @CUBIOCHEM1
https://t.co/VFtGcswyM9
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Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
cell.com
Selective CDK2 inhibition initially blocks substrate phosphorylation. However, because of a potent positive feedback loop and reinforcement by CDK4/6 activity, cells can rapidly overcome CDK2...
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In light of the critical role postdoctoral scientists play in research and the economic challenges faced in the early stages of their careers, Damon Runyon Cancer Research Foundation is pleased to announce a 15% increase in our Fellowship stipend. More:
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