Simone Mattei
@SimoneMattei19
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Cryo-EM aficionado that used tomography and subtomogram averaging to close the gap between HIV cores and Christmas trees.
Joined October 2017
Upside down! Our latest in situ cryo-ET work shows how cytosolic ribosomes bind mitochondria via their SSU as an adaptive response to cellular stress. A great collaboration with @jomaa_lab! #TeamTomo @embl @EmblImaging
https://t.co/9qZTH1mnP8
biorxiv.org
Cell survival under nutrient-deprived conditions relies on cells’ ability to adapt their organelles and to rewire their metabolic pathways. In the fission yeast Schizosaccharomyces pombe , nutrient...
Want to know what happens when mitochondria get stressed? Check our latest pre-print with @SimoneMattei19 lab on how mitochondria tether hibernating ribosomes as an adaptive response to glucose depletion in yeast! https://t.co/G7Ku5KKIsX
#teamtomo #cryoEM #ribosomes #mitochondria
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Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: https://t.co/4WJcgdgRY7
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Grateful to the Boehringer Ingelheim Stiftung for their renewed support. Their commitment empowers us to further advance our mission: enabling broad access to state-of-the-art imaging technologies for the scientific community
Boehringer Ingelheim Stiftung has committed €7 million to EMBL’s Imaging Centre. That means more opportunities to create groundbreaking, next-gen imaging technologies & provide necessary support to European life scientists. https://t.co/DYjHL3rxEH
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Check out our latest preprint with Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint: https://t.co/ebaTAJdFNN
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Thanks to @instructhub funding the @EmblImaging Centre is able to offer an advanced hands-on workshop on cryo-FIB-SEM methods. This is a great opportunity to exchange knowledge with our fantastic cryo-CLEM specialists! Apply here before May 12th:
(1/3) 📣 Apply now: @instructhub INSTRUCT-ERIC hands-on #workshop: Advanced cryo-FIB-SEM methods on 21-25 July 2025. Limited to 12 participants. Apply before 12th May 2025.
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The @ChanZuckerberg Initiative is funding two EMBL projects, coordinated by @EmblImaging, to support imaging technologies development. 🔬 The projects will integrate advanced microscopy techniques to improve the understanding of biological systems. https://t.co/LDxtq74MNA
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Science meets art at the EMBL Imaging Centre! 🔬🎨 Several scientists shared their experience as users of this facility and explain why it is a unique place to turn your research into stunning, informative images. Read the full article here 👉 https://t.co/9U7906MdMM
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Niels Weidemann edited a volume of Methods in Enzymology on mitochondrial import. I was honoured to write a review about yeast genetics together with Maya Schuldiner! I hope it will be useful. https://t.co/Owz7FG2BDE
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It’s great to see our hibernating ribosomes story finally out @NatureComms! Thanks to @jomaa_lab @MedicineUVA and all @EMBL and @EmblImaging people that supported this project.
Happy to share our little discovery with @SimoneMattei19 team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out @NatureComms! A collaboration between @medicineUVA, @EMBL, @EmblImaging, MEMC. Congrats to all authors! https://t.co/DE6eAamt5I
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What if we could peer inside a living organism + watch biology unfold in real-time...down to the microscopic level? 🔬 Researchers like @Prevedel_Lab are working to make this ultra-high res deep tissue imaging possible!
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Fantastic news! All the best for this scientific journey Yura!
I am very honored to get the @ERC_Research StG and looking forward to the next 5 years of exciting research. I am grateful to my mentors and colleagues who helped me along the way! https://t.co/zEHiPFU1jk
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Registration now to the @EMBL Imaging Centre User Symposium 2024! Don't miss this opportunity, especially: ✅ limited workshop by @LeicaMicro and @zeiss_micro ✅ 10 speakers from different expertises More info & registration: https://t.co/slXbbDAvFS
#ImagingTechnology
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How do karyotypes evolve? Turns out an intracellular tug of war within the metaphase spindle sets the limits for chromosome number evolution. Excited to see our study out today in @NatureCellBio
https://t.co/z0zeOTtjBd 1/9
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This is the one 👇🏻
#EMBOCLEM is back and open for applications! 🌟 Learn all about in situ correlative light and electron microscopy while networking and interacting with the experts in the field 🔬 🥼 Course modules include: 🔸 High pressure freezing 🔸 Freeze substitution 🔸 Plunge freezing and
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We are looking for an experienced light microscopy specialist to support the Advanced Light Microscopy Facility @embl Heidelberg: https://t.co/HjIiZoc1Ph - closing date 5 August 2024 @EuLiMI1 @EuroBioImaging @GerBI_GMB @Fr_BioImaging @GlobalBioImage @BioImagingUK
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(1/3) Don’t miss the opportunity to join us at the @EMBL Imaging Centre User Symposium 2024 will be held on 17 to 18 October 2024. Do not miss the deadlines and secure the limited spot. #imaging #CryoEM #superresolution #microscopy. Read more®ister: https://t.co/JQNF8QqJ6X
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We start the second day of @iNEXT_Discovery final meeting with a talk from one of @instructhub facility @EMBLGrenoble
#EasyGrid a versatile platform from #cryoEM sample preparation developed by @PappTeam in collaboration with @EMBLHeidelberg @SimoneMattei19
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We have two open PhD positions to explore structures of ribosomes and gamma-tubulin complexes using cryo-EM approaches here in our group @ZmbhH @UniHeidelberg. Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD:
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I’m excited to share this tour de force by @suman_scifi who conducted an extensive high throughput screen that identified new small molecule entry inhibitors effective against multiple SARS-CoV-2 variants. #COVID19 #Research #Antivirals. https://t.co/HbqbiDFhOj. Short 🧵👇
cell.com
Health sciences; Pharmacology; Virology
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